TripSit · LSD

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

详情

别名

lsd-25 acid cid lucy

分类

致幻剂 常规

相互作用

2c-t-x

风险等级

低风险 · 协同 （Low Risk & Synergy）

2c-x

风险等级

低风险 · 协同 （Low Risk & Synergy）

5-meo-xxt

风险等级

低风险 · 协同 （Low Risk & Synergy）

alcohol

风险等级

Low Risk & Decrease

amphetamines

备注

兴奋剂会增加焦虑水平和思维循环的风险，从而导致负面经历

查看原文

Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences

风险等级

谨慎 （Caution）

amt

风险等级

低风险 · 协同 （Low Risk & Synergy）

benzodiazepines

风险等级

Low Risk & Decrease

caffeine

风险等级

Low Risk & No Synergy

cannabis

备注

大麻与致幻剂具有出乎意料的强烈且有些不可预测的协同作用。

查看原文

Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.

风险等级

谨慎 （Caution）

cocaine

备注

兴奋剂会增加焦虑水平和思维循环的风险，从而导致负面经历

查看原文

Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences

风险等级

谨慎 （Caution）

dextromethorphan

风险等级

低风险 · 协同 （Low Risk & Synergy）

diphenhydramine

备注

25-50 毫克的 DPH 可能有助于缓解 LSD 的副作用，例如恶心和焦虑。在较高剂量时，应注意不要将谵妄剂 (DPH) 与 LSD 联合使用。除了增加严重伤害和精神创伤的风险外，LSD 还可能增加 DPH 的精神错乱和负面影响。休闲剂量的 LSD 和 DPH 会产生额外的心脏问题，例如血管收缩、心动过速、高血压，这些问题组合起来可能会加剧。

查看原文

At 25-50mg, DPH may assist with side effects of the LSD such as nausea and anxiety. At higher dosages, the combination of a deliriant (DPH) and LSD is cautioned against. LSD is likely to increase the deliriant and negative effects of DPH, in addition to increasing the risk of severe injury and mental trauma. LSD and DPH at recreational dosages have additional cardiac concerns such as vasoconstriction, tachycardia, hypertension, which in combination may be exacerbated.

来源

author

Marraffa, J. M. (2014)

标题

Drugs of Abuse. In Encyclopedia of Toxicology (pp. 248–251). Elsevier.

链接

https://doi.org/10.1016/B978-0-12-386454-3.00684-9

author

Passie, T., Halpern, J. H., Stichtenoth, D. O., Emrich, H. M., & Hintzen, A. (2008)

标题

The Pharmacology of Lysergic Acid Diethylamide: A Review. CNS Neuroscience & Therapeutics, 14(4), 295–314.

链接

https://doi.org/10.1111/j.1755-5949.2008.00059.x

author

Schaefer, T. S., Patel, P., & Zito, P. M. (2025)

标题

Antiemetic Histamine H1 Receptor Blockers. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK533003/

author

Schifano, F., Chiappini, S., Miuli, A., Mosca, A., Santovito, M. C., Corkery, J. M., Guirguis, A., Pettorruso, M., Di Giannantonio, M., & Martinotti, G. (2021)

标题

Focus on Over-the-Counter Drugs’ Misuse: A Systematic Review on Antihistamines, Cough Medicines, and Decongestants. Frontiers in Psychiatry, 12, 657397.

链接

https://doi.org/10.3389/fpsyt.2021.657397

author

The drugs of misuse. (2009)

标题

In Auricular Acupuncture & Addiction (pp. 93–135). Elsevier.

链接

https://doi.org/10.1016/B978-0-443-06885-0.50018-5

author

Wolfson, A. R., Wong, D., Abrams, E. M., Waserman, S., & Sussman, G. L. (2022)

标题

Diphenhydramine: Time to Move on? The Journal of Allergy and Clinical Immunology: In Practice, 10(12), 3124–3130.

链接

https://doi.org/10.1016/j.jaip.2022.07.018

风险等级

谨慎 （Caution）

dmt

风险等级

低风险 · 协同 （Low Risk & Synergy）

dox

风险等级

低风险 · 协同 （Low Risk & Synergy）

ghb/gbl

风险等级

Low Risk & Decrease

ketamine

风险等级

低风险 · 协同 （Low Risk & Synergy）

lithium

备注

有大量报告表明这种组合具有较高的癫痫和精神病风险。

查看原文

There are a large number of reports indicating a high seizure and psychosis risk from this combination.

来源

author

Sandeep M Nayak, Natalie Gukasyan, Frederick S Barrett , Earth Erowid , Fire Erowid , Roland R Griffiths

标题

Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports

链接

https://doi.org/10.1055/a-1524-2794

author

Erowid

标题

Erowid Interactions

链接

https://erowid.org/chemicals/lsd/lsd_interactions.shtml

author

freshboi88

标题

I Was Only on One Dose

链接

https://erowid.org/experiences/exp.php?ID=93681

author

YouWerentYouAnymore

标题

Brought My Worst Thoughts to Life

链接

https://erowid.org/experiences/exp.php?ID=110780

author

Otto Simonsson, Peper S. Hendricks, Richard Chambers, Walter Osika, Simon B. Goldberg

标题

Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics

链接

https://doi.org/10.1016/j.jad.2023.01.073

author

Edwards, C., Van Gerpen, S., & Anand, V.

标题

New-Onset Seizures in an Adolescent Following Use of LSD while on Low-Dose Lithium Therapy: A Case Study. (2024)

链接

https://doi.org/10.1177%2F1941874414528939

风险等级

危险（应避免） （Dangerous）

maois

风险等级

Low Risk & Decrease

mdma

风险等级

低风险 · 协同 （Low Risk & Synergy）

mephedrone

备注

兴奋剂的焦虑和集中作用会增加令人不快的思维循环的可能性，此外，在服用迷幻剂时，兴奋剂可能会产生负面副作用。在极端情况下，兴奋剂，尤其是联合使用，可能会导致严重的血管收缩、心动过速、高血压和心力衰竭。

查看原文

The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops, in addition to the possible negative side effects of coming down from said stimulant while on a psychedelic. In extreme cases, stimulants, especially in combination can result in severe vasoconstriction, tachycardia, hypertension, and heart failure.

来源

author

Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein

标题

4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse

链接

https://doi.org/10.1124/jpet.111.184119

author

Michael H Baumann, Mario A Ayestas Jr, John S Partilla, Jacqueline R Sink, Alexander T Shulgin, Paul F Daley, Simon D Brandt, Richard B Rothman, Arnold E Ruoho, Nicholas V Cozzi

标题

The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue

链接

https://doi.org/10.1038/npp.2011.304

author

MJ Wright, Jr, SA Vandewater, D Angrish, 2 TJ Dickerson, and MA Taffe

标题

Mephedrone (4-methylmethcathinone) and d-methamphetamine improve visuospatial associative memory, but not spatial working memory, in rhesus macaques

链接

https://doi.org/10.1111%2Fj.1476-5381.2012.02091.x

author

J Kehr, F Ichinose, S Yoshitake, M Goiny,1, T Sievertsson, F Nyberg, and T Yoshitake

标题

Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats

链接

https://doi.org/10.1111%2Fj.1476-5381.2011.01499.x

author

Jolanta Opacka-Juffry, Thomas Pinnell, Nisha Patel, Melissa Bevan, Meghan Meintel, Colin Davidson

标题

Stimulant mechanisms of cathinones - effects of mephedrone and other cathinones on basal and electrically evoked dopamine efflux in rat accumbens brain slices

链接

https://doi.org/10.1016/j.pnpbp.2014.04.009

author

Schmid Y, Enzler F, Gasser P, Grouzmann E, Preller KH, Vollenweider FX, Brenneisen R, Müller F, Borgwardt S, Liechti ME

标题

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

链接

https://doi.org/10.1016/j.biopsych.2014.11.015

author

Holze F, Vizeli P, Müller F, Ley L, Duerig R, Varghese N, Eckert A, Borgwardt S, Liechti ME

标题

Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects

链接

https://doi.org/10.1038/s41386-019-0569-3

author

Kenneth J Broadley

标题

The vascular effects of trace amines and amphetamines

链接

https://doi.org/10.1016/j.pharmthera.2009.11.005

author

James R. Docherty, Hadeel A. Alsufyani

标题

Cardiovascular and temperature adverse actions of stimulants

链接

https://doi.org/10.1111/bph.15465

author

James R. Docherty DSc, Hadeel A. Alsufyani MB, PhD

标题

Pharmacology of Drugs Used as Stimulants

链接

https://doi.org/10.1002/jcph.1918

author

Breier Y, Azrak E, Banks W, Kushmakov R, Aleshinskaya I

标题

Management of New Onset Amphetamine-Induced Acute Decompensated Heart Failure in a Young Adult: Case Report

链接

https://doi.org/10.7759%2Fcureus.43854

风险等级

谨慎 （Caution）

mescaline

风险等级

低风险 · 协同 （Low Risk & Synergy）

mushrooms

风险等级

低风险 · 协同 （Low Risk & Synergy）

mxe

风险等级

低风险 · 协同 （Low Risk & Synergy）

nbomes

来源

author

Umemura, Y., Andrew, T. A., Jacobs, V. L., Giustini, A. J., Lewis, L. D., & Filiano, J. J.

标题

Fatal 251-NBOMe Intoxication: A New Recreational Risk. Academic Forensic Pathology

链接

https://doi.org/10.23907/2015.009

风险等级

低风险 · 协同 （Low Risk & Synergy）

nitrous

风险等级

低风险 · 协同 （Low Risk & Synergy）

opioids

风险等级

Low Risk & No Synergy

pcp

风险等级

低风险 · 协同 （Low Risk & Synergy）

pregabalin

备注

由于 LSD 的刺激作用和高剂量时普瑞巴林的癫痫发作问题，应小心谨慎。普瑞巴林可以减轻 LSD 的血管收缩、焦虑和其他副作用。此外，普瑞巴林可能会增加 LSD 的抑制作用和受伤风险。

查看原文

Caution should be given due to LSD’s stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the vasoconstriction, anxiety, and other side effects of LSD. Additionally, Pregabalin may increase LSD’s inhibition and risk of injury.

来源

author

Altair. (n.d.-a)

标题

Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”

链接

https://www.erowid.org/experiences/exp.php?ID=69917

author

Baquiran, M., Keyes, D., & Al Khalili, Y. (2025)

标题

Lysergic Acid Diethylamide Toxicity. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK553216/

author

Barker-Haliski, M., & White, H. S. (2015)

标题

Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.

链接

https://doi.org/10.1101/cshperspect.a022863

author

Ben-Menachem, E. (2004)

标题

Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.

链接

https://doi.org/10.1111/j.0013-9580.2004.455003.x

author

Douke, R. (n.d.)

标题

Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”

链接

https://www.erowid.org/experiences/exp.php?ID=83232

author

French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)

标题

Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.

链接

https://doi.org/10.1212/WNL.0000000000000119

author

Gayatri, N. A., & Livingston, J. H. (2006)

标题

Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.

链接

https://doi.org/10.1017/S0012162206000843

author

Hitchings, A. W. (2016)

标题

Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.

链接

https://doi.org/10.1097/FAD.0000000000000016

author

Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)

标题

Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.

链接

https://doi.org/10.1111/bcp.14348

author

Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)

标题

Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.

链接

https://doi.org/10.1111/j.1471-4159.2010.06625.x

author

Sean. (n.d.-b)

标题

Pregabalin - Erowid Exp - “Stay Away.”

链接

https://www.erowid.org/experiences/exp.php?ID=67302

author

Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)

标题

Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.

链接

https://doi.org/10.1080/24734306.2018.1458465

author

Soto-Angona, Ó., Fortea, A., Fortea, L., Martínez-Ramírez, M., Santamarina, E., López, F. J. G., Knudsen, G. M., & Ona, G. (2024)

标题

Do classic psychedelics increase the risk of seizures? A scoping review. European Neuropsychopharmacology, 85, 35–42.

链接

https://doi.org/10.1016/j.euroneuro.2024.05.002

风险等级

谨慎 （Caution）

ssris

风险等级

Low Risk & Decrease

tramadol

备注

众所周知，曲马多可以降低癫痫发作阈值，迷幻药也会引起偶尔的癫痫发作。

查看原文

Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

风险等级

不安全 （Unsafe）

剂量说明

Note: These doses are for pure LSD, note that tabs are often rather a lot weaker than they are advertised.

后遗时间

12-24 小时

剂量

口服

常规

100-150ug

重剂量

250ug+

轻度

50-100ug

强效

175-225ug

持续时间

9-14 小时

效应

visual distortions a sense of childlike wonder brightening of colors racing thoughts hue shifts euphoria anxiety confusion

起效时间

45-90 分钟

相关链接

经验报告

https://www.erowid.org/experiences/subs/exp_LSD.shtml

tihkal

https://www.erowid.org/library/books_online/tihkal/tihkal26.shtml

名称

lsd

通用名

LSD

属性

口服

Light: 50-100ug Common: 100-150ug Strong: 175-225ug Heavy 225ug+ | Note: These doses are for pure LSD, it should be noted that tabs are often a lot weaker than advertised.

后遗效应

12–24 小时

别名

lsd-25 acid cid lucy

avoid

Caution is recommended for cannabis due to potentiation and related change in effects.

分类

致幻剂 常规

剂量

Oral Light: 50-100ug Common: 100-150ug Strong: 175-225ug Heavy: 250ug+ | Note: These doses are for pure LSD, it should be noted that tabs are often a lot weaker than advertised.

持续

9–14 小时 depending on dosages (heavy doses can lead to much longer trips).

效应

visual distortions, a sense of childlike wonder, brightening of colors, racing thoughts, hue shifts, euphoria, anxiety, confusion

half-life

3–5 小时

marquis

Olive black

起效

45–90 分钟 depending on ROA and stomach contents.

摘要

LSD is a popular psychedelic drug with a relatively long history of use and research. It is the archetypical psychedelic and remains in popular usage.

效应

8A Geometry - Exposure to semantic concept network

https://psychonautwiki.org/wiki/8A_Geometry_-_Exposure_to_semantic_concept_network

Acuity enhancement

https://psychonautwiki.org/wiki/Acuity_enhancement

After images

https://psychonautwiki.org/wiki/After_images

Analysis enhancement

https://psychonautwiki.org/wiki/Analysis_enhancement

Auditory distortion

https://psychonautwiki.org/wiki/Auditory_distortion

Auditory enhancement

https://psychonautwiki.org/wiki/Auditory_enhancement

Auditory hallucinations

https://psychonautwiki.org/wiki/Auditory_hallucinations

Autonomous entities

https://psychonautwiki.org/wiki/Autonomous_entities

Bodily control enhancement

https://psychonautwiki.org/wiki/Bodily_control_enhancement

Colour enhancement

https://psychonautwiki.org/wiki/Colour_enhancement

Colour shifting

https://psychonautwiki.org/wiki/Colour_shifting

Conceptual thinking

https://psychonautwiki.org/wiki/Conceptual_thinking

Creativity enhancement

https://psychonautwiki.org/wiki/Creativity_enhancement

Delusions

https://psychonautwiki.org/wiki/Delusions

Depth perception distortions

https://psychonautwiki.org/wiki/Depth_perception_distortions

Drifting

https://psychonautwiki.org/wiki/Drifting

Déjà vu

https://psychonautwiki.org/wiki/D%C3%A9j%C3%A0_vu

Emotion enhancement

https://psychonautwiki.org/wiki/Emotion_enhancement

External hallucinations

https://psychonautwiki.org/wiki/External_hallucinations

Feelings of eternalism

https://psychonautwiki.org/wiki/Feelings_of_eternalism

Feelings of interdependent opposites

https://psychonautwiki.org/wiki/Feelings_of_interdependent_opposites

Feelings of self-design

https://psychonautwiki.org/wiki/Feelings_of_self-design

Geometry

https://psychonautwiki.org/wiki/Geometry

Immersion enhancement

https://psychonautwiki.org/wiki/Immersion_enhancement

Increased heart rate

https://psychonautwiki.org/wiki/Increased_heart_rate

Increased libido

https://psychonautwiki.org/wiki/Increased_libido

Internal hallucinations

https://psychonautwiki.org/wiki/Internal_hallucinations

Laughter

https://psychonautwiki.org/wiki/Laughter

Magnification

https://psychonautwiki.org/wiki/Magnification

Memory suppression

https://psychonautwiki.org/wiki/Memory_suppression

Multiple thought streams

https://psychonautwiki.org/wiki/Multiple_thought_streams

Muscle spasms

https://psychonautwiki.org/wiki/Muscle_spasms

Nausea

https://psychonautwiki.org/wiki/Nausea

Novelty enhancement

https://psychonautwiki.org/wiki/Novelty_enhancement

Pattern recognition enhancement

https://psychonautwiki.org/wiki/Pattern_recognition_enhancement

Personal bias suppression

https://psychonautwiki.org/wiki/Personal_bias_suppression

Personal meaning enhancement

https://psychonautwiki.org/wiki/Personal_meaning_enhancement

Personality regression

https://psychonautwiki.org/wiki/Personality_regression

Perspective alterations

https://psychonautwiki.org/wiki/Perspective_alterations

Perspective distortions

https://psychonautwiki.org/wiki/Perspective_distortions

Physical euphoria

https://psychonautwiki.org/wiki/Physical_euphoria

Pupil dilation

https://psychonautwiki.org/wiki/Pupil_dilation

Recursion

https://psychonautwiki.org/wiki/Recursion

Scenarios and plots

https://psychonautwiki.org/wiki/Scenarios_and_plots

Scenery slicing

https://psychonautwiki.org/wiki/Scenery_slicing

Settings, sceneries, and landscapes

https://psychonautwiki.org/wiki/Settings,_sceneries,_and_landscapes

Simultaneous emotions

https://psychonautwiki.org/wiki/Simultaneous_emotions

Spirituality enhancement

https://psychonautwiki.org/wiki/Spirituality_enhancement

Spontaneous tactile sensations

https://psychonautwiki.org/wiki/Spontaneous_tactile_sensations

Stimulation

https://psychonautwiki.org/wiki/Stimulation

来源

general

Agonistic activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors - http://www.ncbi.nlm.nih.gov/pubmed/9600588 Alterations in responses to LSD in humans associated with chronic administration of tricyclic antidepressants, monoamine oxidase inhibitors or lithium... - http://www.ncbi.nlm.nih.gov/pubmed/8788508 Chronic administration of serotonergic antidepressants attenuates the subjective effects of LSD in humans - http://www.ncbi.nlm.nih.gov/pubmed/8726753 LSD toxicity: a suspected cause of death - http://www.ncbi.nlm.nih.gov/pubmed/845494 Influence of naloxone on the effects of LSD in monkeys. - http://www.ncbi.nlm.nih.gov/pubmed/6527737 Coma, hyperthermia and bleeding associated with massive LSD overdose. A report of eight cases - http://www.ncbi.nlm.nih.gov/pubmed/4816396 Ascorbic acid antagonizes the behavioural effects of LSD in cats - http://www.ncbi.nlm.nih.gov/pubmed/2868111 Illicit use of LSD or psilocybin, but not MDMA or nonpsychedelic drugs, is associated with mystical experiences in a dose-dependent manner - http://www.ncbi.nlm.nih.gov/pubmed/23457892 New Onset LSD Flashback Syndrome Triggered by the Initiation of SSRIs - http://www.ncbi.nlm.nih.gov/pubmed/21603479 LSD and tryptamine effects on sleep/wakefulness and electrocorticogram patterns in intact cats - http://www.ncbi.nlm.nih.gov/pubmed/210478 Characterization of behavioral and endocrine effects of LSD on zebrafish - http://www.ncbi.nlm.nih.gov/pubmed/20561961 Drug dreams in mescaline and LSD addiction - http://www.ncbi.nlm.nih.gov/pubmed/20163393 Response of cluster headache to psilocybin and LSD - http://www.ncbi.nlm.nih.gov/pubmed/16801660 LSD flashback syndrome exacerbated by selective serotonin reuptake inhibitor antidepressants in adolescents - https://www.ncbi.nlm.nih.gov/pubmed/7965440 Metabolism of lysergic acid diethylamide (LSD) to 2-oxo-3-hydroxy LSD (O-H-LSD) in human liver microsomes and cryopreserved human hepatocytes - https://www.ncbi.nlm.nih.gov/pubmed/11043658 LSD-induced entropic brain activity predicts subsequent personality change. - https://www.ncbi.nlm.nih.gov/pubmed/27151536