TripSit · amphetamines + diphenhydramine

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

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安非他明作为兴奋剂可能会掩盖 DPH 的一些负面副作用，导致清醒妄想，这在谵妄状态下更令人担忧。兴奋剂的组合会增加心脏的压力，并可能引起一些身体不适，并有机会引起危及生命的心血管问题。在较高剂量下，该组合还可能增加彼此的神经毒性。除了增加彼此的负面副作用之外，这种组合可能会增加焦虑水平和较高剂量的思维循环风险。据报道，每种物质的医疗剂量和常用剂量都不是问题。此外，除了其他相互作用（例如通过抑制 CYP2D6 和组胺 H1 和 H2 受体增强作用等）之外，DPH 还可以增强安非他明精神运动激活。

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Amphetamines as a stimulant may mask some of the negative side effects of DPH, leading to delusions of sobriety which has additional concern in states of delirium. The combination of stimulants will increase strain on the heart and may cause some physical discomfort, and has the chance to cause life-threatening cardiovascular issues. The combination may also increase each other's neurotoxicity at higher dosages. The combination may increase anxiety levels and risks of thought loops on higher dosages, in addition to increasing each others negative side effects. Medical and common dosages of each substances are reported to not be a concern. Additionally, it is suggested that DPH potentiates amphetamine psychomotor activation, in addition to other interactions such as potentiation through inhibition of CYP2D6 and histamine H1 and H2 receptors, among other alterations.

来源

author

Berman, S. M.; Kuczenski, R.; McCracken, J. T.; London, E. D.

标题

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链接

https://doi.org/10.1038/mp.2008.90

author

Clark, J. H.; Meltzer, E. O.; Naclerio, R. M.

标题

Diphenhydramine: It is time to say a final goodbye. World Allergy Organization Journal, 18(2), 101027 (2025)

链接

https://doi.org/10.1016/j.waojou.2025.101027

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标题

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链接

http://www.ncbi.nlm.nih.gov/books/NBK556103/

author

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标题

Wide complex tachycardia secondary to massive diphenhydramine overdose: a case report. Journal of Emergency and Critical Care Medicine, 6 (2022)

链接

https://doi.org/10.21037/jeccm-21-33

author

Mohs, R. C.; Tinklenberg, J. R.; Roth, W. T.; Kopell, B. S.

标题

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链接

https://doi.org/10.1007/BF00428024

author

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标题

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链接

https://doi.org/10.1016/j.ejphar.2004.10.022

author

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标题

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链接

http://www.ncbi.nlm.nih.gov/books/NBK526010/

author

Steinkellner, T.; Freissmuth, M.; Sitte, H. H.; Montgomery, T.

标题

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链接

https://doi.org/10.1515/BC.2011.016

author

Vasan, S.; Murray, B. P.; Olango, G. J.

标题

Amphetamine Toxicity. In StatPearls. StatPearls Publishing (2025)

链接

http://www.ncbi.nlm.nih.gov/books/NBK470276/

风险等级

谨慎 （Caution）

物质 A

amphetamines

物质 B

diphenhydramine