本条目为第三方公开资料的归档，仅用于学术研究与科普，不构成任何操作指导或医学建议；物质处理涉及法律与健康风险，请在专业、合法的条件下自行核验。
正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。
- 详情
- 别名
- psilocybin shrooms mushroom psylocybin
- 分类
- 致幻剂 常规
- 相互作用
- 2c-t-x
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- 2c-x
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- 5-meo-xxt
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- alcohol
- 风险等级
- Low Risk & Decrease
- amphetamines
- 备注
兴奋剂会增加焦虑水平和思维循环的风险，从而导致负面经历
查看原文
Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- 风险等级
- 谨慎 （Caution）
- amt
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- benzodiazepines
- 风险等级
- Low Risk & Decrease
- caffeine
- 风险等级
- Low Risk & No Synergy
- cannabis
- 备注
大麻与致幻剂具有出乎意料的强烈且有些不可预测的协同作用。
查看原文
Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- 风险等级
- 谨慎 （Caution）
- cocaine
- 备注
兴奋剂会增加焦虑水平和思维循环的风险，从而导致负面经历
查看原文
Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- 风险等级
- 谨慎 （Caution）
- dextromethorphan
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- diphenhydramine
- 备注
25-50 毫克的 DPH 可能有助于缓解裸盖菇素的副作用，例如恶心和焦虑。在较高剂量时，应注意不要将谵妄剂 (DPH) 与裸盖菇素联合使用。裸盖菇素除了增加严重伤害和精神创伤的风险外，还可能增加 DPH 的昏迷和负面影响。
查看原文
At 25-50mg, DPH may assist with side effects of the psilocybin such as nausea and anxiety. At higher dosages, the combination of a deliriant (DPH) and psilocybin is cautioned against. Psilocybin is likely to increase the deliriant and negative effects of DPH, in addition to increasing the risk of severe injury and mental trauma.
- 来源
- author
- Goel, D. B., & Zilate, S. (2022)
- 标题
- Potential Therapeutic Effects of Psilocybin: A Systematic Review. Cureus, 14(10), e30214.
- 链接
- https://doi.org/10.7759/cureus.30214
- author
- Passie, T., Seifert, J., Schneider, U., & Emrich, H. M. (2002)
- 标题
- The pharmacology of psilocybin. Addiction Biology, 7(4), 357–364.
- 链接
- https://doi.org/10.1080/1355621021000005937
- author
- Schaefer, T. S., Patel, P., & Zito, P. M. (2025)
- 标题
- Antiemetic Histamine H1 Receptor Blockers. In StatPearls. StatPearls Publishing.
- 链接
- http://www.ncbi.nlm.nih.gov/books/NBK533003/
- author
- Schifano, F., Chiappini, S., Miuli, A., Mosca, A., Santovito, M. C., Corkery, J. M., Guirguis, A., Pettorruso, M., Di Giannantonio, M., & Martinotti, G. (2021)
- 标题
- Focus on Over-the-Counter Drugs’ Misuse: A Systematic Review on Antihistamines, Cough Medicines, and Decongestants. Frontiers in Psychiatry, 12.
- 链接
- https://doi.org/10.3389/fpsyt.2021.657397
- author
- Wolfson, A. R., Wong, D., Abrams, E. M., Waserman, S., & Sussman, G. L. (2022)
- 标题
- Diphenhydramine: Time to Move on? The Journal of Allergy and Clinical Immunology: In Practice, 10(12), 3124–3130.
- 链接
- https://doi.org/10.1016/j.jaip.2022.07.018
- author
- Yerubandi, A., Thomas, J. E., Bhuiya, N. M. M. A., Harrington, C., Villa Zapata, L., & Caballero, J. (2024)
- 标题
- Acute Adverse Effects of Therapeutic Doses of Psilocybin. JAMA Network Open, 7(4), e245960.
- 链接
- https://doi.org/10.1001/jamanetworkopen.2024.5960
- 风险等级
- 谨慎 （Caution）
- dmt
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- dox
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- ghb/gbl
- 风险等级
- Low Risk & Decrease
- ketamine
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- lithium
- 备注
有大量报告表明这种组合具有较高的癫痫和精神病风险。
查看原文
There are a large number of reports indicating a high seizure and psychosis risk from this combination.
- 来源
- author
- Sandeep M Nayak, Natalie Gukasyan, Frederick S Barrett , Earth Erowid , Fire Erowid , Roland R Griffiths
- 标题
- Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports
- 链接
- https://doi.org/10.1055/a-1524-2794
- author
- Erowid
- 标题
- Erowid Interactions
- 链接
- https://erowid.org/chemicals/lsd/lsd_interactions.shtml
- author
- freshboi88
- 标题
- I Was Only on One Dose
- 链接
- https://erowid.org/experiences/exp.php?ID=93681
- author
- YouWerentYouAnymore
- 标题
- Brought My Worst Thoughts to Life
- 链接
- https://erowid.org/experiences/exp.php?ID=110780
- author
- Otto Simonsson, Peper S. Hendricks, Richard Chambers, Walter Osika, Simon B. Goldberg
- 标题
- Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics
- 链接
- https://doi.org/10.1016/j.jad.2023.01.073
- 风险等级
- 危险（应避免） （Dangerous）
- lsd
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- maois
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- mdma
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- mephedrone
- 备注
兴奋剂会增加焦虑水平和思维循环的风险，从而导致负面经历
查看原文
Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- 来源
- author
- Goel, D. B., & Zilate, S. (2022)
- 标题
- Potential Therapeutic Effects of Psilocybin: A Systematic Review. Cureus, 14(10), e30214.
- 链接
- https://doi.org/10.7759/cureus.30214
- author
- Kehr, J., Ichinose, F., Yoshitake, S., Goiny, M., Sievertsson, T., Nyberg, F., & Yoshitake, T. (2011)
- 标题
- Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats: Mephedrone increases both DA and 5-HT in rat brain. British Journal of Pharmacology, 164(8), 1949–1958.
- 链接
- https://doi.org/10.1111/j.1476-5381.2011.01499.x
- author
- Papaseit, E., Moltó, J., Muga, R., Torrens, M., De La Torre, R., & Farré, M. (2016)
- 标题
- Clinical Pharmacology of the Synthetic Cathinone Mephedrone. In Neuropharmacology of New Psychoactive Substances (NPS) (Vol. 32, pp. 313–331).
- 链接
- https://doi.org/10.1007/7854_2016_61
- author
- Passie, T., Seifert, J., Schneider, U., & Emrich, H. M. (2002)
- 标题
- The pharmacology of psilocybin. Addiction Biology, 7(4), 357–364.
- 链接
- https://doi.org/10.1080/1355621021000005937
- author
- Wood, D. M., Davies, S., Greene, S. L., Button, J., Holt, D. W., Ramsey, J., & Dargan, P. I. (2010)
- 标题
- Case series of individuals with analytically confirmed acute mephedrone toxicity. Clinical Toxicology (Philadelphia, Pa.), 48(9), 924–927.
- 链接
- https://doi.org/10.3109/15563650.2010.531021
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- mescaline
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- mxe
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- nbomes
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- nitrous
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- opioids
- 风险等级
- Low Risk & No Synergy
- pcp
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- pregabalin
- 备注
普瑞巴林可以减轻焦虑和裸盖菇素蘑菇的其他可能的副作用。此外，这种组合可能会增加抑制、头晕和受伤的风险。
查看原文
Pregabalin may reduce the anxiety and other possible side effects of Psilocybin Mushrooms. Additionally, the combination may increase inhibition, dizziness, and risk of injury.
- 来源
- author
- Cross, A. L., Viswanath, O., & Sherman, A. L. (2025)
- 标题
- Pregabalin. In StatPearls. StatPearls Publishing.
- 链接
- http://www.ncbi.nlm.nih.gov/books/NBK470341/
- author
- ScienceDirect Topics. (n.d.)
- 标题
- Psilocybin - an overview
- 链接
- https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/psilocybin
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- ssris
- 风险等级
- Low Risk & Decrease
- tramadol
- 备注
众所周知，曲马多可以降低癫痫发作阈值，迷幻药也会引起偶尔的癫痫发作。
查看原文
Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
- 风险等级
- 不安全 （Unsafe）
- 剂量说明
NOTE: Dosage ranges will vary between fungus strains. The doses given are for *dried* psilocybe cubensis mushrooms. The mushrooms are substantially more potent per-weight when dry.
- 后遗时间
- 1-24 小时
- 剂量
- 口服
- 常规
- 1.5-3.5g
- 轻度
- 0.5-1.5g
- 强效
- 3.5g+
- 持续时间
- 4-6 小时
- 效应
- visual distortion color enhancement sense of connectedness with nature sense of well-being sense of wonder
- 起效时间
- 1 小时
- 相关链接
- 经验报告
- https://www.erowid.org/experiences/subs/exp_Psilocybin.shtml
- 名称
- 致幻蘑菇
- 通用名
- 致幻蘑菇
- 属性
- 后遗效应
- 1–24 小时.
- 别名
- psilocybin shrooms mushroom magic mushrooms psylocybin
- 分类
- 致幻剂 常规
- 剂量
- Oral Light: 0.5-1.5g Common: 1.5-3.5g Strong: 3.5g+ | NOTE: Dosage ranges will vary between fungus strains. The doses given are for *dried* psilocybe cubensis mushrooms. The mushrooms are substantially more potent per-weight when dry.
- 持续
- 4–6 小时
- 效应
- visual distortion, color enhancement, sense of connectedness with nature, sense of well-being, sense of wonder
- half-life
- 1–4 小时
- 起效
- Varies depending on dosage, common doses (see ~drug mushrooms dose) are often felt within two hours. However, reports indicate it may often take up to three hours.
- 摘要
Fungi containing psilocybin, a prototypical psychedelic. It should be noted there are multiple kinds of psychoactive mushrooms and proper identification is essential for safety. The dosages listed are in respects to psilocybe cubensis, one of the most common and popular psilocybin mushroom species.
- 效应
- 8B Geometry - Exposure to inner mechanics of consciousness
- https://psychonautwiki.org/wiki/8B_Geometry_-_Exposure_to_inner_mechanics_of_consciousness
- Acuity enhancement
- https://psychonautwiki.org/wiki/Acuity_enhancement
- After images
- https://psychonautwiki.org/wiki/After_images
- Analysis enhancement
- https://psychonautwiki.org/wiki/Analysis_enhancement
- Auditory distortion
- https://psychonautwiki.org/wiki/Auditory_distortion
- Auditory enhancement
- https://psychonautwiki.org/wiki/Auditory_enhancement
- Auditory hallucinations
- https://psychonautwiki.org/wiki/Auditory_hallucinations
- Autonomous entities
- https://psychonautwiki.org/wiki/Autonomous_entities
- Changes in gravity
- https://psychonautwiki.org/wiki/Changes_in_gravity
- Colour enhancement
- https://psychonautwiki.org/wiki/Colour_enhancement
- Colour shifting
- https://psychonautwiki.org/wiki/Colour_shifting
- Conceptual thinking
- https://psychonautwiki.org/wiki/Conceptual_thinking
- Creativity enhancement
- https://psychonautwiki.org/wiki/Creativity_enhancement
- Delusions
- https://psychonautwiki.org/wiki/Delusions
- Drifting
- https://psychonautwiki.org/wiki/Drifting
- Déjà vu
- https://psychonautwiki.org/wiki/D%C3%A9j%C3%A0_vu
- Emotion enhancement
- https://psychonautwiki.org/wiki/Emotion_enhancement
- Enhancement and suppression cycles
- https://psychonautwiki.org/wiki/Enhancement_and_suppression_cycles
- Excessive yawning
- https://psychonautwiki.org/wiki/Excessive_yawning
- Exposure to inner mechanics of consciousness
- https://psychonautwiki.org/wiki/Exposure_to_inner_mechanics_of_consciousness
- External hallucinations
- https://psychonautwiki.org/wiki/External_hallucinations
- Feelings of interdependent opposites
- https://psychonautwiki.org/wiki/Feelings_of_interdependent_opposites
- Feelings of predeterminism
- https://psychonautwiki.org/wiki/Feelings_of_predeterminism
- Feelings of self-design
- https://psychonautwiki.org/wiki/Feelings_of_self-design
- Geometry
- https://psychonautwiki.org/wiki/Geometry
- Immersion enhancement
- https://psychonautwiki.org/wiki/Immersion_enhancement
- Internal hallucinations
- https://psychonautwiki.org/wiki/Internal_hallucinations
- Memory suppression
- https://psychonautwiki.org/wiki/Memory_suppression
- Mindfulness
- https://psychonautwiki.org/wiki/Mindfulness
- Nausea
- https://psychonautwiki.org/wiki/Nausea
- Novelty enhancement
- https://psychonautwiki.org/wiki/Novelty_enhancement
- Pattern recognition enhancement
- https://psychonautwiki.org/wiki/Pattern_recognition_enhancement
- Personal bias suppression
- https://psychonautwiki.org/wiki/Personal_bias_suppression
- Perspective alterations
- https://psychonautwiki.org/wiki/Perspective_alterations
- Pupil dilation
- https://psychonautwiki.org/wiki/Pupil_dilation
- Runny nose
- https://psychonautwiki.org/wiki/Runny_nose
- Salivation
- https://psychonautwiki.org/wiki/Salivation
- Scenarios and plots
- https://psychonautwiki.org/wiki/Scenarios_and_plots
- Scenery slicing
- https://psychonautwiki.org/wiki/Scenery_slicing
- Sedation
- https://psychonautwiki.org/wiki/Sedation
- Settings, sceneries, and landscapes
- https://psychonautwiki.org/wiki/Settings,_sceneries,_and_landscapes
- Spirituality enhancement
- https://psychonautwiki.org/wiki/Spirituality_enhancement
- Spontaneous tactile sensations
- https://psychonautwiki.org/wiki/Spontaneous_tactile_sensations
- Subconscious communication
- https://psychonautwiki.org/wiki/Subconscious_communication
- Symmetrical texture repetition
- https://psychonautwiki.org/wiki/Symmetrical_texture_repetition
- Synaesthesia
- https://psychonautwiki.org/wiki/Synaesthesia
- Thought connectivity
- https://psychonautwiki.org/wiki/Thought_connectivity
- Time distortion
- https://psychonautwiki.org/wiki/Time_distortion
- Tracers
- https://psychonautwiki.org/wiki/Tracers
- Transformations
- https://psychonautwiki.org/wiki/Transformations
- 来源
- general
- A study done on psilocybin leads psychiatrists to believe there are implications that it may help to treat ptsd - http://bjp.rcpsych.org/content/200/3/238.short
来源与许可
TripSit · 药物资料
TripSit 数据规则：仅限非商业使用，需署名并在每个展示页附来源链接；组合数据仅为快速参考，需结合个体研究判断。
Reference snapshot, not a forum post. Source: TripSit. Noncommercial reuse with TripSit attribution and a source link on every display page; combination data is a quick reference requiring further individual research. https://wiki.tripsit.me/wiki/Factsheets ; https://wiki.tripsit.me/wiki/Drug_combinations . The package.json ISC software tag does not replace these data-specific terms.
Raw source: https://raw.githubusercontent.com/TripSit/drugs/83670cb6bc8863615fcb9be081c87f061b42dea4/drugs.json
Fetched at: 2026-10-23T07:01:06.728397+00:00
Record key: drug:mushrooms
来源主页：https://wiki.tripsit.me/wiki/Factsheets
组合说明：https://wiki.tripsit.me/wiki/Drug_combinations