TripSit · Methylphenidate

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

详情

别名

mph ritalin concerta biphentin

分类

兴奋剂 习惯形成 常规

后遗时间

1-24 小时

剂量

鼻吸

常规

10-20mg

重剂量

30mg+

轻度

5-10mg

强效

20-30mg

口服

常规

10-20mg

重剂量

40mg+

轻度

5-10mg

强效

20-40mg

效应

Increased alertness Euphoria Increased motivation Reduced appetite Flushing of the face Increased body temperature Tachycardia (increased heart rate) Paranoia Insomnia

名称

methylphenidate

通用名

Methylphenidate

属性

后遗效应

1–24 小时.

别名

mph ritalin concerta biphentin

分类

兴奋剂 习惯形成 常规

剂量

Oral Light: 5-10mg Common: 10-20mg Strong: 20-40mg Heavy: 40mg+ | Insufflated Light: 5-10mg Common: 10-20mg Strong: 20-30mg Heavy: 30mg+

持续

Oral-IR: 3–6 小时. | Oral-XR: 8–12 小时. | Insufflated: 2–4 小时. | Note: XR formulations when crushed or otherwise changed become IR before they can be insufflated, so the duration of such is roughly the same as typical IR formulations.

效应

Increased alertness, Euphoria, Increased motivation, Reduced appetite, Flushing of the face, Increased body temperature, Tachycardia (increased heart rate), Paranoia, Insomnia.

marquis

Moderate orange yellow

起效

Oral-IR: 30–120 分钟 | Oral-XR: 30–120 分钟 | Insufflated: 5–10 分钟

摘要

A psychostimulant widely used worldwide as a first-line treatment for ADHD and used in the treatment of narcolepsy. Methylphenidate acts primarily as a norepinephrine–dopamine reuptake inhibitor (NDRI). In many European countries it is commonly prescribed as a first-line option for ADHD where amphetamine-based medications are less frequently used. It has been investigated for off-label use in stimulant dependence, but this is not standard clinical practice.

warning

Extended-release (XR/ER/LA/CR) formulations should not be insufflated. Crushing XR products destroys the release mechanism and introduces large amounts of insoluble fillers, significantly increasing nasal irritation and damage without extending effects. If insufflation occurs, effects are immediate-release only.

效应

Analysis enhancement

https://psychonautwiki.org/wiki/Analysis_enhancement

Anxiety

https://psychonautwiki.org/wiki/Anxiety

Appetite suppression

https://psychonautwiki.org/wiki/Appetite_suppression

Cognitive euphoria

https://psychonautwiki.org/wiki/Cognitive_euphoria

Cognitive fatigue

https://psychonautwiki.org/wiki/Cognitive_fatigue

Dehydration

https://psychonautwiki.org/wiki/Dehydration

Depression

https://psychonautwiki.org/wiki/Depression

Focus enhancement

https://psychonautwiki.org/wiki/Focus_enhancement

Increased heart rate

https://psychonautwiki.org/wiki/Increased_heart_rate

Increased perspiration

https://psychonautwiki.org/wiki/Increased_perspiration

Irritability

https://psychonautwiki.org/wiki/Irritability

Memory enhancement

https://psychonautwiki.org/wiki/Memory_enhancement

Motivation enhancement

https://psychonautwiki.org/wiki/Motivation_enhancement

Stimulation

https://psychonautwiki.org/wiki/Stimulation

Teeth grinding

https://psychonautwiki.org/wiki/Teeth_grinding

Thought acceleration

https://psychonautwiki.org/wiki/Thought_acceleration

Thought deceleration

https://psychonautwiki.org/wiki/Thought_deceleration

Thought organization

https://psychonautwiki.org/wiki/Thought_organization

Wakefulness

https://psychonautwiki.org/wiki/Wakefulness

来源

general

A chemical ionization selected ion monitoring assay for methylphenidate and ritalinic acid - http://www.ncbi.nlm.nih.gov/pubmed/526558 Panlobular pulmonary emphysema caused by i.v. injection of methylphenidate (Ritalin): findings on chest radiographs and CT scans. - http://www.ncbi.nlm.nih.gov/pubmed/8109495 Ethylphenidate formation in human subjects after the administration of a single dose of methylphenidate and ethanol. - https://www.ncbi.nlm.nih.gov/pubmed/10820132 A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague-Dawley rats during... - https://www.ncbi.nlm.nih.gov/pubmed/22289608 Methylphenidate and brain dopamine neurotoxicity. - http://www.ncbi.nlm.nih.gov/pubmed/9365033 Methylphenidate treatment induces oxidative stress in young rat brain. - http://www.ncbi.nlm.nih.gov/pubmed/16494852 A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study. - http://www.ncbi.nlm.nih.gov/pubmed/17201613 Methylphenidate and its ethanol transesterification metabolite ethylphenidate: brain disposition, monoamine transporters and motor activity. - http://www.ncbi.nlm.nih.gov/pubmed/17218796 Methylphenidate combined with aripiprazole in children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder - http://www.ncbi.nlm.nih.gov/pubmed/19877980 Isopropylphenidate: an ester homolog of methylphenidate with sustained and selective dopaminergic activity and reduced drug interaction - http://www.ncbi.nlm.nih.gov/pubmed/24261661 Object memory impairment at post-drug Day 15 but not at Day 1 after a regimen of repeated treatment with oral methylphenidate. - http://www.ncbi.nlm.nih.gov/pubmed/24631430 Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefrontal Cortex of Spontaneously Hypertensive Rats. - http://www.ncbi.nlm.nih.gov/pubmed/26509840 A chemical ionization selected ion monitoring assay for methylphenidate and ritalinic acid. - http://www.ncbi.nlm.nih.gov/pubmed/526558 A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague-Dawley rats during the w... - https://www.ncbi.nlm.nih.gov/pubmed/22289608 Methylphenidate and brain dopamine neurotoxicity. - https://www.ncbi.nlm.nih.gov/pubmed/9365033 Methylphenidate combined with aripiprazole in children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder: a random... - http://www.ncbi.nlm.nih.gov/pubmed/19877980 Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefronta... - http://www.ncbi.nlm.nih.gov/pubmed/26509840 IV use of methylphenidate can lead to infections and abscesses due to the fillers in the medication - http://onlinelibrary.wiley.com/doi/10.1002/hed.2890060409/full Pregnancy category C according to the FDA - http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/010187s069,018029s040,021284s011lbl.pdf Ritalin (methylphenidate) dosage information for adults and pediatric patients. Describes standard oral dosing, starting doses, titration schedules, and a recommended maximum total daily dose of 60 mg, administered in divided doses. - https://www.drugs.com/dosage/ritalin.html NHS guidance on how and when to take methylphenidate for adults. Covers standard tablet dosing, starting doses (5 mg), dose escalation, narcolepsy dosing, and maximum daily dose recommendations, with emphasis on divided dosing. - https://www.nhs.uk/medicines/methylphenidate-adults/how-and-when-to-take-methylphenidate-for-adults/ Mayo Clinic clinical reference for oral methylphenidate. Provides dosing information for short-acting tablets in adults and children, including typical daily dose ranges, divided administration, and a recommended maximum daily dose of 60 mg. - https://www.mayoclinic.org/drugs-supplements/methylphenidate-oral-route/description/drg-20068297 Riatlin works on Norepinephrine–dopamine reuptake inhibitor (NDRI) mechanism - https://en.wikipedia.org/wiki/Methylphenidate