TripSit · Cocaine

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

详情

别名

coke

分类

兴奋剂 习惯形成 常规

相互作用

2c-t-x

备注

可卡因和 2c-t-x 都提供相当大的刺激。当它们结合在一起时，会导致严重的血管收缩、心动过速、高血压，在极端情况下还会导致心力衰竭。

查看原文

Cocaine and 2c-t-x both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.

风险等级

不安全 （Unsafe）

2c-x

备注

兴奋剂的焦虑和集中作用会增加产生不愉快的思维循环的可能性。由于迷幻药的刺激作用，这种组合通常是不必要的。刺激作用的结合可能会令人不舒服。

查看原文

The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.

风险等级

谨慎 （Caution）

5-meo-xxt

备注

The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.

风险等级

不安全 （Unsafe）

alcohol

备注

可卡因可以减少酒精的一些醉人作用，导致一些人比平时喝酒更多，从而导致更大的行为和身体健康风险。关于可卡乙烯（一种酒精和可卡因混合产生的代谢物）也存在一些争议，一些研究人员认为它比可卡因本身的心脏毒性更大。混合这些物质时要适量。

查看原文

Cocaine can decrease some of the intoxicating effects of alcohol, causing some people to drink more than they otherwise would, which leads to greater behavioral and physical health risks. There is also some debate about cocaethylene, a metabolite produced when combining alcohol and cocaine, with some researchers positing that it is more cardiotoxic than cocaine on its own. Use moderation when combining these substances.

来源

author

McCance-Katz, E. F., Kosten, T. R., & Jatlow, P.

标题

Concurrent use of cocaine and alcohol is more potent and potentially more toxic than use of either alone—A multiple-dose study.

链接

https://doi.org/10.1016/S0006-3223(97)00426-5

author

Pergolizzi, J., Breve, F., Magnusson, P., LeQuang, J. A. K., & Varrassi, G.

标题

Cocaethylene: When cocaine and alcohol are taken together. (2022)

链接

https://doi.org/10.7759/cureus.22498

author

Shastry, S., Manoochehri, O., Richardson, L. D., & Manini, A. F.

标题

Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose.

链接

https://doi.org/10.1111/acem.14584

author

Wiener, S. E., Sutijono, D., Moon, C. H., Subramanian, R. A., Calaycay, J., Rushbrook, J. I., & Zehtabchi, S.

标题

Patients with detectable cocaethylene are more likely to require intensive care unit admission after trauma.

链接

https://doi.org/10.1016/j.ajem.2009.06.014

风险等级

不安全 （Unsafe）

amphetamines

备注

这种兴奋剂的组合会增加心脏的压力。通常不值得，因为可卡因对安非他明等多巴胺释放剂有轻微的阻断作用

查看原文

This combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamine releasers like amphetamine

风险等级

谨慎 （Caution）

amt

风险等级

危险（应避免） （Dangerous）

benzodiazepines

风险等级

Low Risk & Decrease

caffeine

备注

这两种兴奋剂都有导致心动过速、高血压的风险，在极端情况下还可能导致心力衰竭。

查看原文

Both stimulants, risk of tachycardia, hypertension, and in extreme cases heart failure.

风险等级

谨慎 （Caution）

cannabis

备注

兴奋剂会增加焦虑水平和思维循环的风险，从而导致负面经历

查看原文

Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences

风险等级

谨慎 （Caution）

dextromethorphan

备注

这两种物质都会增加心率，在极端情况下，这些药物引起的恐慌会导致更严重的心脏问题

查看原文

Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues

风险等级

不安全 （Unsafe）

diphenhydramine

备注

兴奋剂会增加呼吸频率，从而允许使用比正常剂量更高的镇静剂。如果可卡因先失效，娱乐性剂量的 DPH 可能会抑制个体并导致呼吸停止。这两种物质在娱乐剂量下都会使心脏紧张，并可能导致进一步危险的心脏并发症。当较高剂量的 DPH 与可卡因结合在一起时，这两种物质可能会产生更强的增强作用，并具有更大的高铁血红蛋白血症风险。

查看原文

Stimulants increase respiration rate allowing for a higher dose of sedatives than normal. If cocaine wears off first, recreational dosages of DPH may overcome the individual and cause respiratory arrest. Both substances at recreational dosages strain the heart and may lead to further dangerous heart complications. When taken together, both substances can potentially be more reinforcing and have greater risk of methemoglobinemia when higher dosages of DPH are combined with cocaine.

来源

author

Alanazi, M. Q.

标题

Drugs may be Induced Methemoglobinemia. Journal of Hematology & Thromboembolic Diseases, 06(01). (2017)

链接

https://doi.org/10.4172/2329-8790.1000270

author

Banks, M. L., Andersen, M. L., Murnane, K. S., Meyer, R. C., & Howell, L. L.

标题

Behavioral and neurochemical effects of cocaine and diphenhydramine combinations in rhesus monkeys. Psychopharmacology, 205(3), 467–474. (2009)

链接

https://doi.org/10.1007/s00213-009-1555-y

author

chrisn

标题

Diphenhydramine [Online post]. Drug-Forum. (2021)

链接

https://drugs-forum.com/wiki/Diphenhydramine

author

Eshmandi, M., Mohamed, A., Khalil, B., & Belhaj, A.

标题

Methaemoglobinaemia Associated With Mixed Cocaine and Amphetamine Overdose: A Case Report. Cureus, 16(1), e51748. (2024)

链接

https://doi.org/10.7759/cureus.51748

author

Karch, S. B.

标题

Diphenhydramine toxicity: comparisons of postmortem findings in diphenhydramine-, cocaine-, and heroin-related deaths. The American Journal of Forensic Medicine and Pathology, 19(2), 143–147. (1998)

链接

https://doi.org/10.1097/00000433-199806000-00008

author

Pennefather, J. N.

标题

The effects pf cocaine and diphenhydramine upon the reactivity of rat vas deferens to supramaximal doses of noradrenaline and of other agonists: The mode of action of cocaine. European Journal of Pharmacology, 35(2), 333–339. (1976)

链接

https://doi.org/10.1016/0014-2999(76)90236-3

author

Pergolizzi, J. V., Magnusson, P., LeQuang, J. A. K., Breve, F., & Varrassi, G.

标题

Cocaine and Cardiotoxicity: A Literature Review. Cureus, 13(4), e14594. (2021)

链接

https://doi.org/10.7759/cureus.14594

author

Sicari, V., Patel, P., & Zabbo, C. P.

标题

Diphenhydramine. In StatPearls. StatPearls Publishing. (2025)

链接

http://www.ncbi.nlm.nih.gov/books/NBK526010/

author

Tanda, G., Kopajtic, T. A., & Katz, J. L.

标题

Cocaine-Like Neurochemical Effects of Antihistaminic Medications. Journal of Neurochemistry, 106(1), 147–157. (2008)

链接

https://doi.org/10.1111/j.1471-4159.2008.05361.x

author

Wang, Z., & Woolverton, W. L.

标题

Self-administration of cocaine-antihistamine combinations: Super-additive reinforcing effects. European Journal of Pharmacology, 557(2–3), 159–160. (2007)

链接

https://doi.org/10.1016/j.ejphar.2006.11.056

author

Wang, Z., & Woolverton, W. L.

标题

Super-additive interaction of the reinforcing effects of cocaine and H1-antihistamines in rhesus monkeys. Pharmacology Biochemistry and Behavior, 91(4), 590–595. (2009)

链接

https://doi.org/10.1016/j.pbb.2008.09.013

author

Weichert, I.

标题

Acute Management of Cocaine-Associated Methaemoglobinaemia. Case Reports in Medicine, 2011, 1–3. (2011)

链接

https://doi.org/10.1155/2011/136396

风险等级

谨慎 （Caution）

dmt

备注

兴奋剂会增加焦虑水平和思维循环的风险，从而导致负面经历

查看原文

Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences

风险等级

谨慎 （Caution）

dox

备注

两者的综合刺激作用会导致身体不适，而可卡因的聚焦作用很容易导致思维循环。在 DOx 仍然活跃的情况下戒除可卡因可能会引起焦虑

查看原文

The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic

风险等级

不安全 （Unsafe）

ghb/gbl

备注

兴奋剂会增加呼吸频率，从而允许使用比正常剂量更高的镇静剂。如果兴奋剂首先失效，阿片类药物可能会控制个体并导致呼吸停止。同样，ghb/gbl 会逐渐消失并留下危险浓度的可卡因

查看原文

Stimulants increase respiration rate allowing for a higher dose of sedatives than normal. If the stimulant wears off first the opiate may overcome the individual and cause respiratory arrest. Likewise the ghb/gbl can wear off and leave a dangerous concentration of cocaine behind

风险等级

谨慎 （Caution）

ketamine

备注

没有意外的相互作用，虽然可能会导致血压升高，但合理剂量不存在问题。由于身体受伤的风险，服用高剂量的这种组合可能是不明智的。

查看原文

No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.

风险等级

谨慎 （Caution）

lithium

备注

锂可能会抑制可卡因的一些娱乐作用。

查看原文

Lithium may inhibit some of the recreational effects of cocaine.

来源

author

Flemenbaum, A.

标题

Antagonism of behavioral effects of cocaine by lithium. (1977)

链接

https://doi.org/10.1016/0091-3057(77)90015-6

author

Cronson, A. J., & Flemenbaum, A.

标题

Antagonism of Cocaine Highs by Lithium. (1981)

链接

https://doi.org/10.1007/978-1-4684-3614-3_132

风险等级

Low Risk & Decrease

lsd

备注

兴奋剂会增加焦虑水平和思维循环的风险，从而导致负面经历

查看原文

Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences

风险等级

谨慎 （Caution）

maois

备注

这种组合的探索很少

查看原文

This combination is poorly explored

风险等级

危险（应避免） （Dangerous）

mdma

备注

可卡因会阻碍 MDMA 的一些理想效果，同时增加心脏病发作的风险。

查看原文

Cocaine blocks some of the desirable effects of MDMA while increasing the risk of heart attack.

风险等级

谨慎 （Caution）

mescaline

备注

迷幻药会放大兴奋剂引起的注意力集中和焦虑，导致思维循环的风险增加

查看原文

The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops

风险等级

谨慎 （Caution）

mushrooms

备注

兴奋剂会增加焦虑水平和思维循环的风险，从而导致负面经历

查看原文

Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences

风险等级

谨慎 （Caution）

mxe

备注

与 MXE 一起服用的兴奋剂更容易导致过度躁狂状态，尤其是在避免睡眠的情况下。

查看原文

Stimulants taken with MXE can lead to hypermanic states much more easily, especially if sleep is avoided.

风险等级

谨慎 （Caution）

nbomes

备注

可卡因和 NBOMes 都提供相当大的刺激。当它们结合在一起时，会导致严重的血管收缩、心动过速、高血压，在极端情况下还会导致心力衰竭。

查看原文

Cocaine and NBOMes both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.

风险等级

不安全 （Unsafe）

nitrous

风险等级

低风险 · 协同 （Low Risk & Synergy）

opioids

备注

兴奋剂会增加呼吸频率，从而使阿片类药物的剂量高于正常剂量。如果兴奋剂首先消失，那么阿片类药物可能会控制个体并导致呼吸停止。

查看原文

Stimulants increase respiration rate allowing for a higher dose of opiates than normal. If the stimulant wears off first then the opiate may overcome the individual and cause respiratory arrest.

风险等级

危险（应避免） （Dangerous）

pcp

备注

这种组合很容易导致过度躁狂状态

查看原文

This combination can easily lead to hypermanic states

风险等级

不安全 （Unsafe）

pregabalin

备注

这种组合存在癫痫发作的显着风险。兴奋剂会增加呼吸频率，从而允许使用比正常剂量更高的镇静剂。如果可卡因首先消失，娱乐性剂量的普瑞巴林可能会抑制个体并导致呼吸停止。这两种物质在娱乐剂量下都会使心脏紧张，并可能导致进一步危险的心脏并发症。当组合更高剂量时，该组合具有更大的高铁血红蛋白血症风险。

查看原文

There is a significant risk of seizures from this combination. Stimulants increase respiration rate, allowing for a higher dose of sedatives than normal. If cocaine wears off first, recreational dosages of pregabalin may overcome the individual and cause respiratory arrest. Both substances at recreational dosages strain the heart and may lead to further dangerous heart complications. The combination has a greater risk of methemoglobinemia when higher dosages are combined.

来源

author

Altair. (n.d.-a)

标题

Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure: Not Recreational.”

链接

https://www.erowid.org/experiences/exp.php?ID=69917

author

Barker-Haliski, M., & White, H. S. (2015)

标题

Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.

链接

https://doi.org/10.1101/cshperspect.a022863

author

Ben-Menachem, E. (2004)

标题

Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.

链接

https://doi.org/10.1111/j.0013-9580.2004.455003.x

author

Douke, R. (n.d.)

标题

Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”

链接

https://www.erowid.org/experiences/exp.php?ID=83232

author

French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)

标题

Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.

链接

https://doi.org/10.1212/WNL.0000000000000119

author

Gayatri, N. A., & Livingston, J. H. (2006)

标题

Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.

链接

https://doi.org/10.1017/S0012162206000843

author

Hitchings, A. W. (2016)

标题

Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.

链接

https://doi.org/10.1097/FAD.0000000000000016

author

Hunter, L., Gordge, L., Dargan, P. I., & Wood, D. M. (2011)

标题

Methaemoglobinaemia associated with the use of cocaine and volatile nitrites as recreational drugs: a review. British Journal of Clinical Pharmacology, 72(1), 18–26.

链接

https://doi.org/10.1111/j.1365-2125.2011.03950.x

author

Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)

标题

Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.

链接

https://doi.org/10.1111/bcp.14348

author

Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)

标题

Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.

链接

https://doi.org/10.1111/j.1471-4159.2010.06625.x

author

Lappin, J. M., & Sara, G. E. (2019)

标题

Psychostimulant use and the brain. Addiction, 114(11), 2065–2077.

链接

https://doi.org/10.1111/add.14708

author

Ludlow, J. T., Wilkerson, R. G., & Nappe, T. M. (2025)

标题

Methemoglobinemia. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK537317/

author

Pergolizzi, J. V., Magnusson, P., LeQuang, J. A. K., Breve, F., & Varrassi, G. (n.d.)

标题

Cocaine and Cardiotoxicity: A Literature Review. Cureus, 13(4), e14594.

链接

https://doi.org/10.7759/cureus.14594

author

Sean. (n.d.-b)

标题

Pregabalin - Erowid Exp - “Stay Away.”

链接

https://www.erowid.org/experiences/exp.php?ID=67302

author

Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)

标题

Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.

链接

https://doi.org/10.1080/24734306.2018.1458465

风险等级

不安全 （Unsafe）

ssris

备注

可能会降低彼此的效率。 Cocaine can reduce mental stability and therefore exacerbate conditions which SSRIs are used to treat.

查看原文

May reduce each others' effectiveness. Cocaine can reduce mental stability and therefore exacerbate conditions which SSRIs are used to treat.

风险等级

Low Risk & No Synergy

tramadol

备注

曲马多和兴奋剂都会增加癫痫发作的风险。

查看原文

Tramadol and stimulants both increase the risk of seizures.

风险等级

危险（应避免） （Dangerous）

剂量说明

起效快。根据纯度，剂量会有所不同

查看原文

Rapid onset. Depending on purity, dosage will vary

后遗时间

1-4 小时

剂量

鼻吸

常规

50-100mg

重剂量

150mg+

轻度

20-50mg

强效

100-150mg

持续时间

1-1.5 小时

效应

Elevated mood Increase in irritability hyper-inflated ego euphoria stimulation raised heartrate numbing effects depending on ROA nausea (particularly at high doses)

相关链接

经验报告

https://www.erowid.org/experiences/subs/exp_Cocaine.shtml

名称

可卡因

通用名

可卡因

属性

后遗效应

1–4 小时.

别名

coke

生物利用度

Cocaine Oral 25-35% | Insufflated 40-60%. NOTE: This is for Cocaine HCl.

分类

兴奋剂 习惯形成 常规

检测窗口

Saliva: 1 天, Urine: 4–5 天, Hair: up to 90 天

剂量

Insufflated Light: 20-50mg Common: 50-100mg Strong: 100-150mg Heavy: 150mg+ | NOTE: Depending on purity, dosage will vary

持续

1–1.5 小时

效应

Elevated mood. Increase in irritability, hyper-inflated ego, euphoria, stimulation, raised heartrate, numbing effects depending on ROA, nausea (particularly at high doses)

marquis

Clear (No change)

起效

Rapid.

摘要

A highly popular, short-acting CNS stimulant that works by blocking the reuptake of dopamine, serotonin, and norepinephrine. It is known to increase euphoria, confidence, sex-drive, focus, body temperature, and heart rate. Cocaine can cause severe vasoconstriction and is known to be cardiotoxic and have a high potential for compulsive redosing and addiction.

效应

Abnormal heartbeat

https://psychonautwiki.org/wiki/Abnormal_heartbeat

Anxiety

https://psychonautwiki.org/wiki/Anxiety

Appetite suppression

https://psychonautwiki.org/wiki/Appetite_suppression

Bronchodilation

https://psychonautwiki.org/wiki/Bronchodilation

Cognitive euphoria

https://psychonautwiki.org/wiki/Cognitive_euphoria

Cognitive fatigue

https://psychonautwiki.org/wiki/Cognitive_fatigue

Compulsive redosing

https://psychonautwiki.org/wiki/Compulsive_redosing

Dehydration

https://psychonautwiki.org/wiki/Dehydration

Depression

https://psychonautwiki.org/wiki/Depression

Disinhibition

https://psychonautwiki.org/wiki/Disinhibition

Ego inflation

https://psychonautwiki.org/wiki/Ego_inflation

Focus enhancement

https://psychonautwiki.org/wiki/Focus_enhancement

Increased blood pressure

https://psychonautwiki.org/wiki/Increased_blood_pressure

Increased heart rate

https://psychonautwiki.org/wiki/Increased_heart_rate

Increased libido

https://psychonautwiki.org/wiki/Increased_libido

Increased perspiration

https://psychonautwiki.org/wiki/Increased_perspiration

Irritability

https://psychonautwiki.org/wiki/Irritability

Motivation enhancement

https://psychonautwiki.org/wiki/Motivation_enhancement

Pain relief

https://psychonautwiki.org/wiki/Pain_relief

Stimulation

https://psychonautwiki.org/wiki/Stimulation

Teeth grinding

https://psychonautwiki.org/wiki/Teeth_grinding

Temporary erectile dysfunction

https://psychonautwiki.org/wiki/Temporary_erectile_dysfunction

Thought acceleration

https://psychonautwiki.org/wiki/Thought_acceleration

Thought deceleration

https://psychonautwiki.org/wiki/Thought_deceleration

Thought organization

https://psychonautwiki.org/wiki/Thought_organization

Vasoconstriction

https://psychonautwiki.org/wiki/Vasoconstriction

Wakefulness

https://psychonautwiki.org/wiki/Wakefulness

来源

general

Rhabdomyolysis associated with cocaine abuse. -https://www.ncbi.nlm.nih.gov/pubmed/1743698 Rhabdomyolysis associated with cocaine abuse. - https://www.ncbi.nlm.nih.gov/pubmed/1743698 The beta-lactam antibiotic ceftriaxone inhibits physical dependence and abstinence-induced withdrawal from cocaine, amphetamine, methamphetamine, a... - https://www.ncbi.nlm.nih.gov/pubmed/18342307 Effects of concurrent use of alcohol and cocaine. - http://www.ncbi.nlm.nih.gov/pubmed/12133112 Cocaine-like neurochemical effects of antihistaminic medications. - http://www.ncbi.nlm.nih.gov/pubmed/18363822 Cocaine cardiotoxicity: a review of the pathophysiology, pathology, and treatment options. - http://www.ncbi.nlm.nih.gov/pubmed/19463023 Citalopram enhances cocaine's subjective effects in rats. - http://www.ncbi.nlm.nih.gov/pubmed/20195220 Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias. - http://www.ncbi.nlm.nih.gov/pubmed/20573078 High cocaine dosage decreases neurogenesis in the hippocampus and impairs working memory. - http://www.ncbi.nlm.nih.gov/pubmed/20731634 The effects of combinations of intranasal cocaine, smoked marijuana, and task performance on heart rate and blood pressure. - http://www.ncbi.nlm.nih.gov/pubmed/2162543 Lack of cocaine-like discriminative-stimulus effects of σ-receptor agonists in rats. - http://www.ncbi.nlm.nih.gov/pubmed/21808192 Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat. - http://www.ncbi.nlm.nih.gov/pubmed/22734646 Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-ind... - http://www.ncbi.nlm.nih.gov/pubmed/23681166 Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects. - http://www.ncbi.nlm.nih.gov/pubmed/23761390 Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters. - http://www.ncbi.nlm.nih.gov/pubmed/24296074 Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefronta... - http://www.ncbi.nlm.nih.gov/pubmed/26509840 Cocaine tolerance and cross-tolerance. - http://www.ncbi.nlm.nih.gov/pubmed/8093724 Cocaethylene is as cardiotoxic as cocaine but is less toxic than cocaine plus ethanol. - http://www.ncbi.nlm.nih.gov/pubmed/8761012 Differential potentiation of L-tryptophan-induced head-twitch response in mice by cocaine and sertraline. - http://www.ncbi.nlm.nih.gov/pubmed/8831798 Cocaine contamination of United States paper currency. - http://www.ncbi.nlm.nih.gov/pubmed/8835657 A study suggests that having a history of cocaine and poly drug abuse can lead to acute open-angle glaucoma - http://journals.lww.com/glaucomajournal/Abstract/2011/09000/Substance_Use_Disorder_and_the_Risk_of_Open_angle.9.aspx using cocaine while pregnant is dangerous for the fetus's health - https://www.drugabuse.gov/publications/research-reports/cocaine/what-are-effects-maternal-cocaine-use