TripSit · Caffeine

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

详情

别名

coffee

分类

兴奋剂 习惯形成 促智剂 常规

相互作用

2c-t-x

备注

高剂量的咖啡因可能会引起焦虑，而这种焦虑在绊倒时更难以控制，并且由于两者都有刺激作用，因此组合可能会导致一些身体不适。

查看原文

High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.

风险等级

Low Risk & No Synergy

2c-x

备注

高剂量的咖啡因可能会引起焦虑，而这种焦虑在绊倒时更难以控制，并且由于两者都有刺激作用，因此组合可能会导致一些身体不适。

查看原文

High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.

风险等级

Low Risk & No Synergy

5-meo-xxt

备注

高剂量的咖啡因可能会引起焦虑，而这种焦虑在绊倒时更难以控制，并且由于两者都有刺激作用，因此组合可能会导致一些身体不适。

查看原文

High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.

风险等级

Low Risk & No Synergy

alcohol

风险等级

Low Risk & No Synergy

amphetamines

备注

这种兴奋剂组合通常是不必要的，可能会增加心脏负担，并可能导致焦虑和更大的身体不适。

查看原文

This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.

风险等级

谨慎 （Caution）

amt

备注

高剂量的咖啡因可能会引起焦虑，而这种焦虑在绊倒时更难以控制，并且由于两者都有刺激作用，因此组合可能会导致一些身体不适。

查看原文

High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.

风险等级

谨慎 （Caution）

benzodiazepines

风险等级

Low Risk & Decrease

cannabis

风险等级

Low Risk & No Synergy

cocaine

备注

这两种兴奋剂都有导致心动过速、高血压的风险，在极端情况下还可能导致心力衰竭。

查看原文

Both stimulants, risk of tachycardia, hypertension, and in extreme cases heart failure.

风险等级

谨慎 （Caution）

dextromethorphan

备注

高剂量的咖啡因具有刺激作用，可能会加剧焦虑，尤其是在分离体验期间。这种组合也可能导致身体不适。然而，个人对咖啡因的反应可能有很大差异，通常受到习惯和偶尔使用等因素的影响。

查看原文

High doses of caffeine can potentially exacerbate anxiety, especially during a dissociative experience, due to its stimulating effects. This combination might also lead to physical discomfort. However, individual responses to caffeine can vary significantly, often influenced by factors like habitual versus occasional usage.

来源

author

Chad J Reissig, Lawrence P Carter, Matthew W Johnson, Miriam Z Mintzer, Margaret A Klinedinst, Roland R Griffiths

标题

High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens

链接

https://pubmed.ncbi.nlm.nih.gov/22526529/

author

Arthur Eumann Mesas, Luz M Leon-Muñoz, Fernando Rodriguez-Artalejo, Esther Lopez-Garcia

标题

The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis

链接

https://pubmed.ncbi.nlm.nih.gov/21880846/

author

M-L Nurminen, L Niittynen, R Korpela & H Vapaatalo

标题

Coffee, caffeine and blood pressure: a critical review

链接

https://www.nature.com/articles/1600899

风险等级

谨慎 （Caution）

diphenhydramine

备注

咖啡因作为兴奋剂可能会掩盖 DPH 的一些负面副作用，导致清醒妄想，这在谵妄状态下会引起额外的担忧。兴奋剂的组合会增加心脏的负担，可能会引起一些身体不适，并有机会引起心血管问题，例如复杂性心动过速。除了增加彼此的负面副作用之外，这种组合在较高剂量下可能会增加焦虑水平和思维循环的风险。据报道，医疗剂量不是一个问题。

查看原文

Caffeine as a stimulant may mask some negative side effects of DPH, leading to delusions of sobriety, which has additional concerns in states of delirium. The combination of stimulants will increase strain on the heart and may cause some physical discomfort, and has the chance to cause cardiovascular issues such as complex tachycardia. The combination may increase anxiety levels and risks of thought loops at higher dosages, in addition to increasing each other's negative side effects. Medical dosages are reported to not be a concern.

来源

author

Clark, J. H.; Meltzer, E. O.; Naclerio, R. M. (2025)

标题

Diphenhydramine: It is time to say a final goodbye. World Allergy Organization Journal, 18(2), 101027.

链接

https://doi.org/10.1016/j.waojou.2025.101027

author

Evans, J.; Richards, J. R.; Battisti, A. S. (2025)

标题

Caffeine. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK519490/

author

McAtee, K. J.; Brillhart, D.; Barbuto, A. F.; Hiller, H. M. (2022)

标题

Wide complex tachycardia secondary to massive diphenhydramine overdose: a case report. Journal of Emergency and Critical Care Medicine, 6(0).

链接

https://doi.org/10.21037/jeccm-21-33

author

Murray, A.; Traylor, J. (2025)

标题

Caffeine Toxicity. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK532910/

author

Institute of Medicine (US) Committee on Military Nutrition Research (2001)

标题

Pharmacology of Caffeine. In Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. National Academies Press (US).

链接

https://www.ncbi.nlm.nih.gov/books/NBK223808/

author

Sicari, V.; Patel, P.; Zabbo, C. P. (2025)

标题

Diphenhydramine. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK526010/

author

Tharion, W. J.; Kobrick, J. L.; Lieberman, H. R.; Fine, B. J. (1993)

标题

Effects of caffeine and diphenhydramine on auditory evoked cortical potentials. Perceptual and Motor Skills, 76(3 Pt 1), 707–715.

链接

https://doi.org/10.2466/pms.1993.76.3.707

风险等级

谨慎 （Caution）

dmt

风险等级

Low Risk & No Synergy

dox

备注

高剂量的咖啡因可能会引起焦虑，而这种焦虑在绊倒时更难以控制，而且由于两者都有刺激作用，因此可能会导致一些身体不适。

查看原文

High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.

风险等级

谨慎 （Caution）

ghb/gbl

风险等级

Low Risk & No Synergy

ketamine

备注

没有意外的互动。

查看原文

No unexpected interactions.

风险等级

Low Risk & No Synergy

lsd

风险等级

Low Risk & No Synergy

maois

风险等级

Low Risk & No Synergy

mdma

备注

咖啡因对于 MDMA 来说并不是必需的，咖啡因会增加 MDMA 的神经毒性作用

查看原文

Caffeine is not really necessary with MDMA and increases any neurotoxic effects from MDMA

风险等级

谨慎 （Caution）

mephedrone

备注

这种兴奋剂的组合通常是不必要的，并且可能会增加心脏的压力，并可能导致焦虑和严重的身体不适。然而，个人对咖啡因的反应可能有很大差异，通常受到习惯和偶尔使用等因素的影响。

查看原文

This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and great physical discomfort. However, individual responses to caffeine can vary significantly, often influenced by factors like habitual versus occasional usage.

来源

author

Mesas AE, Leon-Muñoz LM, Rodriguez-Artalejo F, Lopez-Garcia E

标题

The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis

链接

https://doi.org/10.3945/ajcn.111.016667

author

Nurminen, ML., Niittynen, L., Korpela, R

标题

Coffee, caffeine and blood pressure: a critical review

链接

https://doi.org/10.1038/sj.ejcn.1600899

author

Institute of Medicine (US) Committee on Military Nutrition Research.

标题

Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations.

链接

https://www.ncbi.nlm.nih.gov/books/NBK223808/

author

Baumann MH, Ayestas MA Jr, Partilla JS, Sink JR, Shulgin AT, Daley PF, Brandt SD, Rothman RB, Ruoho AE, Cozzi NV

标题

The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue

链接

https://doi.org/10.1038/npp.2011.304

author

Wright MJ Jr, Vandewater SA, Angrish D, Dickerson TJ, Taffe MA

标题

Mephedrone (4-methylmethcathinone) and d-methamphetamine improve visuospatial associative memory, but not spatial working memory, in rhesus macaques

链接

https://doi.org/10.1111%2Fj.1476-5381.2012.02091.x

author

Kehr J, Ichinose F, Yoshitake S, Goiny M, Sievertsson T, Nyberg F, Yoshitake T

标题

Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats

链接

https://doi.org/10.1111%2Fj.1476-5381.2011.01499.x

风险等级

谨慎 （Caution）

mescaline

备注

高剂量的咖啡因会让人感到不舒服，迷幻药会加剧这种不适

查看原文

High doses of caffeine are uncomfortable and this will be magnified by psychedelics

风险等级

Low Risk & No Synergy

mushrooms

风险等级

Low Risk & No Synergy

mxe

备注

没有可能的相互作用

查看原文

No likely interactions

风险等级

Low Risk & No Synergy

nbomes

备注

咖啡因可以带出迷幻药物的自然刺激，使人感到不舒服。高剂量会引起焦虑，在绊倒时难以应对

查看原文

Caffeine can bring out the natural stimulation from psychedelic drugs to make it uncomfortable. High doses can cause anxiety which is hard to handle while tripping

风险等级

谨慎 （Caution）

nitrous

风险等级

Low Risk & No Synergy

opioids

风险等级

Low Risk & No Synergy

pcp

备注

这种组合的细节尚不清楚，但 PCP 通常以不可预测的方式相互作用。

查看原文

Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.

风险等级

谨慎 （Caution）

pregabalin

备注

这种组合存在癫痫发作的风险，尤其是在较高剂量时。较低剂量的咖啡因还会降低普瑞巴林的抗惊厥作用。咖啡因会增加呼吸频率，因此需要比正常剂量更高的镇静剂剂量。如果安非他明首先失效，娱乐性剂量的普瑞巴林可能会抑制个体并导致呼吸停止。这两种物质在娱乐剂量下都会导致心脏紧张，并可能导致进一步危险的心脏并发症。医疗剂量不太可能引起关注。

查看原文

There is a risk of seizures from this combination, especially at higher dosages. Caffeine additionally reduces pregabalin’s anticonvulsant effects found in lower dosages. Caffeine increases respiration rate allowing for a higher dose of sedatives than normal. If amphetamines wears off first, recreational dosages of pregabalin may overcome the individual and cause respiratory arrest. Both substances at recreational dosages cause strain of the heart and may lead to further dangerous heart complications. Medical dosages are unlikely to be of concern.

来源

author

Barker-Haliski, M., & White, H. S. (2015)

标题

Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.

链接

https://doi.org/10.1101/cshperspect.a022863

author

Ben‐Menachem, E. (2004)

标题

Pregabalin Pharmacology and Its Relevance to Clinical Practice. Epilepsia, 45(s6), 13–18.

链接

https://doi.org/10.1111/j.0013-9580.2004.455003.x

author

Chwedorowicz, R., Łukawski, K., Raszewski, G., & Czuczwar, S. J. (2022)

标题

Effect of caffeine on the anticonvulsant action of pregabalin against electroconvulsions in mice. Pharmacological Reports: PR, 74(2), 431–437.

链接

https://doi.org/10.1007/s43440-022-00356-1

author

French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)

标题

Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial. Neurology, 82(7), 590–597.

链接

https://doi.org/10.1212/WNL.0000000000000119

author

Gayatri, N., & Livingston, J. (2006)

标题

Aggravation of epilepsy by anti‐epileptic drugs. Developmental Medicine & Child Neurology, 48(5), 394–398.

链接

https://doi.org/10.1017/S0012162206000843

author

Hitchings, A. W. (2016)

标题

Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.

链接

https://doi.org/10.1097/FAD.0000000000000016

author

Sean. (n.d.-b)

标题

Pregabalin - Erowid Exp - “Stay Away.”

链接

https://www.erowid.org/experiences/exp.php?ID=67302

author

Altair. (n.d.-a)

标题

Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”

链接

https://www.erowid.org/experiences/exp.php?ID=69917

author

Douke, R. (n.d.)

标题

Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”

链接

https://www.erowid.org/experiences/exp.php?ID=83232

author

Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)

标题

Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.

链接

https://doi.org/10.1111/bcp.14348

author

Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)

标题

Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.

链接

https://doi.org/10.1111/j.1471-4159.2010.06625.x

author

Miziak, B., Błaszczyk, B., Chrościńska-Krawczyk, M., & Czuczwar, S. J. (2023)

标题

Caffeine and Its Interactions with Antiseizure Medications—Is There a Correlation between Preclinical and Clinical Data? International Journal of Molecular Sciences, 24(24), 17569.

链接

https://doi.org/10.3390/ijms242417569

author

Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)

标题

Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.

链接

https://doi.org/10.1080/24734306.2018.1458465

风险等级

不安全 （Unsafe）

ssris

风险等级

Low Risk & No Synergy

tramadol

风险等级

Low Risk & No Synergy

剂量说明

NOTE: The lethal dose for caffeine starts at approximately 3g. The average cup of coffee contains roughly 75-150mg of caffeine.

后遗时间

3-4 小时

剂量

口服

常规

75mg-250mg

重剂量

400mg+

轻度

20-75mg

强效

250-400mg

阈值

10-20mg

持续时间

1.5-5 小时

效应

elevated heartrate increase in cognitive abilities physical agitation panicked thinking racing thoughts uncomfortable bodyload

起效时间

5-10 分钟

相关链接

经验报告

https://www.erowid.org/experiences/subs/exp_Caffeine.shtml

名称

咖啡因

通用名

咖啡因

属性

后遗效应

3–4 小时

别名

coffee

生物利用度

Orally it varies from around 77%-99%

分类

兴奋剂 习惯形成 促智剂 常规

剂量

Threshold: 10-20mg Light: 20-75mg Common: 75mg-250mg Strong: 250-400mg Heavy: 400mg+ | NOTE: The lethal dose for caffeine starts at approximately 3g. The average cup of coffee contains roughly 75-150mg of caffeine.

持续

1.5–5 小时

效应

elevated heartrate, increase in cognitive abilities, physical agitation, panicked thinking, racing thoughts, uncomfortable bodyload

起效

5–10 分钟

摘要

Caffeine is a CNS stimulant and the most widely used psychoactive substance in the world. It is legal and unregulated in most parts of the world, and is found in many commonly sold products. It has a good safety profile, though regular heavy use can cause physical dependence and contribute to certain medical conditions.

效应

Analysis enhancement

https://psychonautwiki.org/wiki/Analysis_enhancement

Anxiety

https://psychonautwiki.org/wiki/Anxiety

Appetite suppression

https://psychonautwiki.org/wiki/Appetite_suppression

Bronchodilation

https://psychonautwiki.org/wiki/Bronchodilation

Cognitive euphoria

https://psychonautwiki.org/wiki/Cognitive_euphoria

Cognitive fatigue

https://psychonautwiki.org/wiki/Cognitive_fatigue

Depression

https://psychonautwiki.org/wiki/Depression

Focus enhancement

https://psychonautwiki.org/wiki/Focus_enhancement

Frequent urination

https://psychonautwiki.org/wiki/Frequent_urination

Increased blood pressure

https://psychonautwiki.org/wiki/Increased_blood_pressure

Increased heart rate

https://psychonautwiki.org/wiki/Increased_heart_rate

Increased libido

https://psychonautwiki.org/wiki/Increased_libido

Irritability

https://psychonautwiki.org/wiki/Irritability

Memory enhancement

https://psychonautwiki.org/wiki/Memory_enhancement

Motivation enhancement

https://psychonautwiki.org/wiki/Motivation_enhancement

Stimulation

https://psychonautwiki.org/wiki/Stimulation

Tactile enhancement

https://psychonautwiki.org/wiki/Tactile_enhancement

Thought acceleration

https://psychonautwiki.org/wiki/Thought_acceleration

Thought deceleration

https://psychonautwiki.org/wiki/Thought_deceleration

Vasoconstriction

https://psychonautwiki.org/wiki/Vasoconstriction

Wakefulness

https://psychonautwiki.org/wiki/Wakefulness