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TripSit · N2O

TripSit 参考资料 · 药物资料 2026-10-23

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本条目为第三方公开资料的归档，仅用于学术研究与科普，不构成任何操作指导或医学建议；物质处理涉及法律与健康风险，请在专业、合法的条件下自行核验。

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

详情

别名

laughing_gas n20 n2o nos nitrous oxide hippy crack

分类

解离剂习惯形成常规

相互作用

2c-t-x

风险等级: 低风险 · 协同（Low Risk & Synergy）

2c-x

风险等级: 低风险 · 协同（Low Risk & Synergy）

5-meo-xxt

风险等级: 低风险 · 协同（Low Risk & Synergy）

alcohol

备注: 这两种物质都会增强另一种物质引起的共济失调和镇静作用，高剂量时可能会导致意外的意识丧失。在失去知觉时，如果不处于恢复姿势，则有呕吐物误吸的风险。内存中断是有可能的。

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Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
风险等级: 谨慎（Caution）

amphetamines

风险等级: 低风险 · 协同（Low Risk & Synergy）

amt

风险等级: 低风险 · 协同（Low Risk & Synergy）

benzodiazepines

风险等级: Low Risk & Decrease

caffeine

风险等级: Low Risk & No Synergy

cannabis

风险等级: 低风险 · 协同（Low Risk & Synergy）

cocaine

风险等级: 低风险 · 协同（Low Risk & Synergy）

dextromethorphan

风险等级: 低风险 · 协同（Low Risk & Synergy）

dmt

风险等级: 低风险 · 协同（Low Risk & Synergy）

dox

风险等级: 低风险 · 协同（Low Risk & Synergy）

ghb/gbl

备注: 这两种物质都会增强另一种物质引起的共济失调和镇静作用，高剂量时可能会导致意外的意识丧失。在失去知觉时，如果不处于恢复姿势，则有呕吐物误吸的风险。内存中断是有可能的。

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Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
风险等级: 谨慎（Caution）

ketamine

风险等级: 低风险 · 协同（Low Risk & Synergy）

lithium

备注

我们无法找到有关锂引起中枢神经系统抑制的报告。

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We are unable to find a report of concerns for CNS depression caused by Lithium.

来源

author: Drugbank
标题: Lithium Carbonate
链接: https://go.drugbank.com/drugs/DB14509

风险等级

Low Risk & No Synergy

lsd

风险等级: 低风险 · 协同（Low Risk & Synergy）

maois

风险等级: Low Risk & No Synergy

mdma

风险等级: 低风险 · 协同（Low Risk & Synergy）

mescaline

风险等级: 低风险 · 协同（Low Risk & Synergy）

mushrooms

风险等级: 低风险 · 协同（Low Risk & Synergy）

mxe

风险等级: 低风险 · 协同（Low Risk & Synergy）

nbomes

风险等级: 低风险 · 协同（Low Risk & Synergy）

opioids

备注: 这两种物质都会增强另一种物质引起的共济失调和镇静作用，高剂量时可能会导致意外的意识丧失。在失去知觉时，如果不处于恢复姿势，则有呕吐物误吸的风险。内存中断是有可能的。

查看原文
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
风险等级: 谨慎（Caution）

pcp

风险等级: 低风险 · 协同（Low Risk & Synergy）

pregabalin

备注

这两种物质都会增强另一种物质引起的共济失调和镇静作用，并且在较高剂量时可能会增加意识丧失的风险。在失去知觉时，如果不处于恢复姿势，则有呕吐物误吸的风险。该组合可能会增加抑制作用和受伤风险。此外，在普瑞巴林的影响下滥用亚硝酸可能会增加癫痫发作的风险。医疗剂量不太可能成为问题。

查看原文

Both substances potentiate the ataxia and sedation caused by the other, and may increase the risk of loss of consciousness at higher dosages. While unconscious, vomit aspiration is a risk if not placed in the recovery position. The combination may increase inhibition and risk of injury. Additionally, abuse of nitrous while under the influence of pregabalin may increase the risk of seizures. Medical dosages are unlikely to be a concern.

来源

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Ben‐Menachem, E. (2004)
标题: Pregabalin Pharmacology and Its Relevance to Clinical Practice. Epilepsia, 45(s6), 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Cross, A. L., Viswanath, O., & Sherman, A. L. (2025)
标题: Pregabalin. In StatPearls. StatPearls Publishing.
链接: http://www.ncbi.nlm.nih.gov/books/NBK470341/

author: Davidson, L. T. (2023)
标题: Recreational use of nitrous oxide causes seizure, pneumothorax, pneumomediastinum, and pneumopericardium: nitrous oxide and its harm, a case report. Upsala Journal of Medical Sciences, 128, 10.48101/ujms.v128.10281.
链接: https://doi.org/10.48101/ujms.v128.10281

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N., & Livingston, J. (2006)
标题: Aggravation of epilepsy by anti‐epileptic drugs. Developmental Medicine & Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Knuf, K., & Maani, C. V. (2025)
标题: Nitrous Oxide. In StatPearls. StatPearls Publishing.
链接: http://www.ncbi.nlm.nih.gov/books/NBK532922/

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

author: Wagner, S., Clark, M., Wesche, D., Doedens, D., & Lloyd, A. (1992)
标题: Asphyxial Deaths from the Recreational Use of Nitrous Oxide. Journal of Forensic Sciences, 37(4), 1008–1015.
链接: https://doi.org/10.1520/JFS13286J

风险等级

谨慎（Caution）

ssris

风险等级: Low Risk & No Synergy

tramadol

备注: 这两种物质都会增强另一种物质引起的共济失调和镇静作用，高剂量时可能会导致意外的意识丧失。在失去知觉时，如果不处于恢复姿势，则有呕吐物误吸的风险。内存中断是有可能的。

查看原文
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
风险等级: 谨慎（Caution）

后遗时间

15-30 分钟

持续时间

1-5 分钟

效应

giggling mood lift euphoria sound distortion dream like state minor to strong hallucinations reduction of external stimuli analgesia buzzing sensation in nerve clumsiness nausea headaches numbness in extremities

起效时间

0-1 分钟

名称

nitrous

通用名

N2O

属性

后遗效应: 15–30 分钟
别名: laughing_gas n20 n2o nos hippy crack
分类: 解离剂习惯形成常规
持续: 1–5 分钟
效应: giggling, mood lift, euphoria, sound distortion, dream like state, minor to strong hallucinations, reduction of external stimuli, analgesia, buzzing sensation in nerve, clumsiness, nausea, headaches, numbness in extremities
起效: 0–1 分钟
摘要: Nitrous oxide, also known as laughing gas, is often inhaled through balloons filled with canisters of the gas. The drug is a short-acting dissociative inhalant with strong visual, mental, and auditory effects. The drug is extremely popular especially in combination with other drugs.

效应

Acuity suppression: https://psychonautwiki.org/wiki/Acuity_suppression
Amnesia: https://psychonautwiki.org/wiki/Amnesia
Auditory distortion: https://psychonautwiki.org/wiki/Auditory_distortion
Auditory suppression: https://psychonautwiki.org/wiki/Auditory_suppression
Changes in felt bodily form: https://psychonautwiki.org/wiki/Changes_in_felt_bodily_form
Cognitive euphoria: https://psychonautwiki.org/wiki/Cognitive_euphoria
Compulsive redosing: https://psychonautwiki.org/wiki/Compulsive_redosing
Depersonalization: https://psychonautwiki.org/wiki/Depersonalization
Derealization: https://psychonautwiki.org/wiki/Derealization
Dizziness: https://psychonautwiki.org/wiki/Dizziness
Double vision: https://psychonautwiki.org/wiki/Double_vision
Déjà vu: https://psychonautwiki.org/wiki/D%C3%A9j%C3%A0_vu
External hallucinations: https://psychonautwiki.org/wiki/External_hallucinations
Frame rate suppression: https://psychonautwiki.org/wiki/Frame_rate_suppression
Geometry: https://psychonautwiki.org/wiki/Geometry
Headaches: https://psychonautwiki.org/wiki/Headaches
Information processing suppression: https://psychonautwiki.org/wiki/Information_processing_suppression
Internal hallucinations: https://psychonautwiki.org/wiki/Internal_hallucinations
Laughter: https://psychonautwiki.org/wiki/Laughter
Memory suppression: https://psychonautwiki.org/wiki/Memory_suppression
Motor control loss: https://psychonautwiki.org/wiki/Motor_control_loss
Pattern recognition suppression: https://psychonautwiki.org/wiki/Pattern_recognition_suppression
Perception of decreased weight: https://psychonautwiki.org/wiki/Perception_of_decreased_weight
Physical euphoria: https://psychonautwiki.org/wiki/Physical_euphoria
Spontaneous tactile sensations: https://psychonautwiki.org/wiki/Spontaneous_tactile_sensations
Suggestibility enhancement: https://psychonautwiki.org/wiki/Suggestibility_enhancement
Tactile suppression: https://psychonautwiki.org/wiki/Tactile_suppression
Thought deceleration: https://psychonautwiki.org/wiki/Thought_deceleration
Unity and interconnectedness: https://psychonautwiki.org/wiki/Unity_and_interconnectedness

来源

general: Ketamine potentiates cerebrocortical damage induced by the common anaesthetic agent nitrous oxide in adult rats - http://www.ncbi.nlm.nih.gov/pubmed/10928976 Severe neurotoxicity following intrathecal methotrexate with nitrous oxide sedation in a child with acute lymphoblastic leukemia - http://www.ncbi.nlm.nih.gov/pubmed/25360802 Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency - http://www.ncbi.nlm.nih.gov/pubmed/8250714

来源与许可

TripSit · 药物资料

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Reference snapshot, not a forum post. Source: TripSit. Noncommercial reuse with TripSit attribution and a source link on every display page; combination data is a quick reference requiring further individual research. https://wiki.tripsit.me/wiki/Factsheets ; https://wiki.tripsit.me/wiki/Drug_combinations . The package.json ISC software tag does not replace these data-specific terms. Raw source: https://raw.githubusercontent.com/TripSit/drugs/83670cb6bc8863615fcb9be081c87f061b42dea4/drugs.json Fetched at: 2026-10-23T07:01:06.728397+00:00 Record key: drug:nitrous

来源主页：https://wiki.tripsit.me/wiki/Factsheets
组合说明：https://wiki.tripsit.me/wiki/Drug_combinations