TripSit · dextromethorphan + mxe

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备注

由于 DXM 和 MXE 都是 SRI，因此将 DXM 与 MXE 结合使用时存在血清素综合征的风险。 MXE 和 DXM 对血清素转运蛋白具有显着的亲和力。

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There is a risk of serotonin syndrome when combining DXM with MXE, due to DXM and MXE both being SRI’s. MXE and DXM having notable affinities for the serotonin transporter.

来源

author

Bryan L. Roth, Simon Gibbons, Warunya Arunotayanun, Xi-Ping Huang, Vincent Setola, Ric Treble, Les Iversen

标题

The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor

链接

https://doi.org/10.1371/journal.pone.0059334

author

Matteo Marti, Giuseppe Talani, Cristina Miliano, Sabrine Bilel, Francesca Biggio, Jessica Bratzu, Marco Diana, Maria Antonietta De Luca, Liana Fattore

标题

New insights into methoxetamine mechanisms of action: Focus on serotonergic 5-HT2 receptors in pharmacological and behavioral effects in the rat

链接

https://doi.org/10.1016/j.expneurol.2021.113836

author

Laura Hondebrink, Emma E.J. Kasteel, Anke M. Tukker, Fiona M.J. Wijnolts, Anouk H.A. Verboven, Remco H.S. Westerink

标题

Neuropharmacological characterization of the new psychoactive substance methoxetamine

链接

https://doi.org/10.1016/j.neuropharm.2017.04.035

author

Linda L. Werling, Ashleigh Keller, Julie G. Frank, Samer J. Nuwayhid

标题

A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: Treatment of involuntary emotional expression disorder

链接

https://doi.org/10.1016/j.expneurol.2007.06.013

author

Linda Nguyen, Kelan L. Thomas, Brandon P. Lucke-Wold, John Z. Cavendish, Molly S. Crowe, Rae R. Matsumoto

标题

Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders

链接

https://doi.org/10.1016/j.pharmthera.2016.01.016

风险等级

不安全 （Unsafe）

物质 A

dextromethorphan

物质 B

mxe