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正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。
- 详情
- 备注
普瑞巴林和DXM可能会相互增强抑制、头晕、镇静等作用。如果剂量较高，可能会导致意外的意识丧失。两种药物都有癫痫发作的风险，联合使用会大大增加。
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Pregabalin and DXM may increase each other’s effects such as inhibition, dizziness, sedation. At higher doses this can lead to unexpected loss of consciousness. Both drugs have seizure concerns which is greatly increased in combination.
- 来源
- author
- Altair. (n.d.-a)
- 标题
- Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
- 链接
- https://www.erowid.org/experiences/exp.php?ID=69917
- author
- Barker-Haliski, M., & White, H. S. (2015)
- 标题
- Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
- 链接
- https://doi.org/10.1101/cshperspect.a022863
- author
- Ben-Menachem, E. (2004)
- 标题
- Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
- 链接
- https://doi.org/10.1111/j.0013-9580.2004.455003.x
- author
- Douke, R. (n.d.)
- 标题
- Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
- 链接
- https://www.erowid.org/experiences/exp.php?ID=83232
- author
- French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
- 标题
- Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.
- 链接
- https://doi.org/10.1212/WNL.0000000000000119
- author
- Gayatri, N. A., & Livingston, J. H. (2006)
- 标题
- Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.
- 链接
- https://doi.org/10.1017/S0012162206000843
- author
- Hitchings, A. W. (2016)
- 标题
- Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
- 链接
- https://doi.org/10.1097/FAD.0000000000000016
- author
- Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
- 标题
- Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
- 链接
- https://doi.org/10.1111/bcp.14348
- author
- Journey, J. D., Agrawal, S., & Stern, E. (2025)
- 标题
- Dextromethorphan Toxicity. In StatPearls. StatPearls Publishing.
- 链接
- http://www.ncbi.nlm.nih.gov/books/NBK538502/
- author
- Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
- 标题
- Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
- 链接
- https://doi.org/10.1111/j.1471-4159.2010.06625.x
- author
- Oh, S., Agrawal, S., Sabir, S., & Taylor, A. (2025)
- 标题
- Dextromethorphan. In StatPearls. StatPearls Publishing.
- 链接
- http://www.ncbi.nlm.nih.gov/books/NBK538216/
- author
- Sean. (n.d.-b)
- 标题
- Pregabalin - Erowid Exp - “Stay Away.”
- 链接
- https://www.erowid.org/experiences/exp.php?ID=67302
- author
- Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
- 标题
- Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
- 链接
- https://doi.org/10.1080/24734306.2018.1458465
- 风险等级
- 不安全 （Unsafe）
- 物质 A
- dextromethorphan
- 物质 B
- pregabalin
来源与许可
TripSit · 药物资料
TripSit 数据规则：仅限非商业使用，需署名并在每个展示页附来源链接；组合数据仅为快速参考，需结合个体研究判断。
Reference snapshot, not a forum post. Source: TripSit. Noncommercial reuse with TripSit attribution and a source link on every display page; combination data is a quick reference requiring further individual research. https://wiki.tripsit.me/wiki/Factsheets ; https://wiki.tripsit.me/wiki/Drug_combinations . The package.json ISC software tag does not replace these data-specific terms.
Raw source: https://raw.githubusercontent.com/TripSit/drugs/83670cb6bc8863615fcb9be081c87f061b42dea4/combos.json
Fetched at: 2026-10-23T07:01:06.728397+00:00
Record key: combination:["dextromethorphan","pregabalin"]
来源主页：https://wiki.tripsit.me/wiki/Factsheets
组合说明：https://wiki.tripsit.me/wiki/Drug_combinations