TripSit · maois + diphenhydramine

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

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备注

这种组合存在发生血清素综合征的显着风险。单胺氧化酶 A 抑制剂可能会延长和增强 DPH 的抗胆碱能作用。这种组合会增加彼此的副作用，例如嗜睡、头晕、口干和头痛。据报道，医疗剂量不值得关注。

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There is a significant risk of serotonin syndrome with this combination. Monoamine oxidase A inhibitors may extend and increase the anticholinergic effects of DPH. The combination increases each other’s side effects, such as drowsiness, dizziness, dry mouth, and headaches. Medical dosages are not reported to be of concern.

来源

author

Adawi Awdish, R. L., Whitmill, M., Coba, V., & Killu, K. (2008)

标题

Serotonin Reuptake Inhibition by Diphenhydramine and concomitant Linezolid use can result in Serotonin Syndrome Chest, 134(4), 4C.

链接

https://doi.org/10.1378/chest.134.4_MeetingAbstracts.c4002

author

Clark, J. H., Meltzer, E. O., & Naclerio, R. M. (2025)

标题

Diphenhydramine: It is time to say a final goodbye. The World Allergy Organization Journal, 18(2), 101027.

链接

https://doi.org/10.1016/j.waojou.2025.101027

author

Edinoff, A. N., Swinford, C. R., Odisho, A. S., Burroughs, C. R., Stark, C. W., Raslan, W. A., Cornett, E. M., Kaye, A. M., & Kaye, A. D. (n.d.)

标题

Clinically Relevant Drug Interactions with Monoamine Oxidase Inhibitors. Health Psychology Research, 10(4), 39576.

链接

https://doi.org/10.52965/001c.39576

author

Gillman, P. K. (2005)

标题

Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434–441.

链接

https://doi.org/10.1093/bja/aei210

author

Khan, S., Saud, S., Khan, I., Asif, M., Ismail, O., Salam, A., Yang, T. J., & Norville, K. J. (2018)

标题

Serotonin Syndrome Presenting with Concomitant Tramadol and Diphenhydramine Use: A Case Report of an Unlikely Side-Effect. Cureus.

链接

https://doi.org/10.7759/cureus.2421

author

López-Álvarez, J., Sevilla-Llewellyn-Jones, J., & Agüera-Ortiz, L. (2019)

标题

Anticholinergic Drugs in Geriatric Psychopharmacology. Frontiers in Neuroscience, 13, 1309.

链接

https://doi.org/10.3389/fnins.2019.01309

author

Sub Laban, T., & Saadabadi, A. (2025)

标题

Monoamine Oxidase Inhibitors (MAOI). In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK539848/

风险等级

不安全 （Unsafe）

物质 A

maois

物质 B

diphenhydramine