TripSit · diphenhydramine + mxe

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

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备注

这种组合导致血清素综合征的风险很高。这两种物质都会增强另一种物质引起的共济失调和镇静作用，高剂量时可能会导致意外的意识丧失。在失去知觉时，如果不处于恢复姿势，则有呕吐物误吸的风险。较高剂量的 MXE 很可能会增加 DPH 的谵妄作用，并可能大大增加受伤、躁狂和精神病的风险。医疗剂量不太可能引起关注。

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There is a high risk of serotonin syndrome from this combination. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. MXE has a high likelihood of increasing DPH's deliriant effects at higher dosages and can greatly increase the risk of injury, mania, and psychosis. Medical dosages are unlikely to be of concern.

来源

author

Clark, J. H., Meltzer, E. O., & Naclerio, R. M. (2025)

标题

Diphenhydramine: It is time to say a final goodbye. World Allergy Organization Journal, 18(2), 101027.

链接

https://doi.org/10.1016/j.waojou.2025.101027

author

Ener, R. A., Meglathery, S. B., Decker, W. A. V., & Gallagher, R. M. (2003)

标题

Serotonin Syndrome and Other Serotonergic Disorders: Table 1. Pain Medicine, 4(1), 63–74.

链接

https://doi.org/10.1046/j.1526-4637.2003.03005.x

author

Marti, M., Talani, G., Miliano, C., Bilel, S., Biggio, F., Bratzu, J., Diana, M., De Luca, M. A., & Fattore, L. (2021)

标题

New insights into methoxetamine mechanisms of action: Focus on serotonergic 5-HT2 receptors in pharmacological and behavioral effects in the rat. Experimental Neurology, 345, 113836.

链接

https://doi.org/10.1016/j.expneurol.2021.113836

author

Roth, B. L., Gibbons, S., Arunotayanun, W., Huang, X.-P., Setola, V., Treble, R., & Iversen, L. (2013)

标题

The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor. PLoS ONE, 8(3), e59334.

链接

https://doi.org/10.1371/journal.pone.0059334

author

Varghese, E., Abate, M. A., Hu, L., Kaplan, J., Kraner, J., Long, D. L., Sorg, M., Mock, A., Greenwald, M., & Andrew, T. (2015)

标题

Characterization of Diphenhydramine-Related Accidental Overdose Deaths. Academic Forensic Pathology, 5(1), 105–115.

链接

https://doi.org/10.23907/2015.011

风险等级

危险（应避免） （Dangerous）

物质 A

diphenhydramine

物质 B

mxe