TripSit · caffeine + pregabalin

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

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这种组合存在癫痫发作的风险，尤其是在较高剂量时。较低剂量的咖啡因还会降低普瑞巴林的抗惊厥作用。咖啡因会增加呼吸频率，因此需要比正常剂量更高的镇静剂剂量。如果安非他明首先失效，娱乐性剂量的普瑞巴林可能会抑制个体并导致呼吸停止。这两种物质在娱乐剂量下都会导致心脏紧张，并可能导致进一步危险的心脏并发症。医疗剂量不太可能引起关注。

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There is a risk of seizures from this combination, especially at higher dosages. Caffeine additionally reduces pregabalin’s anticonvulsant effects found in lower dosages. Caffeine increases respiration rate allowing for a higher dose of sedatives than normal. If amphetamines wears off first, recreational dosages of pregabalin may overcome the individual and cause respiratory arrest. Both substances at recreational dosages cause strain of the heart and may lead to further dangerous heart complications. Medical dosages are unlikely to be of concern.

来源

author

Barker-Haliski, M., & White, H. S. (2015)

标题

Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.

链接

https://doi.org/10.1101/cshperspect.a022863

author

Ben‐Menachem, E. (2004)

标题

Pregabalin Pharmacology and Its Relevance to Clinical Practice. Epilepsia, 45(s6), 13–18.

链接

https://doi.org/10.1111/j.0013-9580.2004.455003.x

author

Chwedorowicz, R., Łukawski, K., Raszewski, G., & Czuczwar, S. J. (2022)

标题

Effect of caffeine on the anticonvulsant action of pregabalin against electroconvulsions in mice. Pharmacological Reports: PR, 74(2), 431–437.

链接

https://doi.org/10.1007/s43440-022-00356-1

author

French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)

标题

Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial. Neurology, 82(7), 590–597.

链接

https://doi.org/10.1212/WNL.0000000000000119

author

Gayatri, N., & Livingston, J. (2006)

标题

Aggravation of epilepsy by anti‐epileptic drugs. Developmental Medicine & Child Neurology, 48(5), 394–398.

链接

https://doi.org/10.1017/S0012162206000843

author

Hitchings, A. W. (2016)

标题

Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.

链接

https://doi.org/10.1097/FAD.0000000000000016

author

Sean. (n.d.-b)

标题

Pregabalin - Erowid Exp - “Stay Away.”

链接

https://www.erowid.org/experiences/exp.php?ID=67302

author

Altair. (n.d.-a)

标题

Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”

链接

https://www.erowid.org/experiences/exp.php?ID=69917

author

Douke, R. (n.d.)

标题

Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”

链接

https://www.erowid.org/experiences/exp.php?ID=83232

author

Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)

标题

Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.

链接

https://doi.org/10.1111/bcp.14348

author

Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)

标题

Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.

链接

https://doi.org/10.1111/j.1471-4159.2010.06625.x

author

Miziak, B., Błaszczyk, B., Chrościńska-Krawczyk, M., & Czuczwar, S. J. (2023)

标题

Caffeine and Its Interactions with Antiseizure Medications—Is There a Correlation between Preclinical and Clinical Data? International Journal of Molecular Sciences, 24(24), 17569.

链接

https://doi.org/10.3390/ijms242417569

author

Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)

标题

Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.

链接

https://doi.org/10.1080/24734306.2018.1458465

风险等级

不安全 （Unsafe）

物质 A

咖啡因

物质 B

pregabalin