TripSit · ketamine + pregabalin

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

详情

备注

普瑞巴林和氯胺酮可能会产生协同作用，并增加彼此的负面副作用，例如恶心、头晕和意识丧失。由于癫痫发作的担忧，建议谨慎使用超出医疗剂量的药物，以及针对癫痫发作风险较高和/或行为较高的个人的医疗剂量。

查看原文

Pregabalin and ketamine may synergize and increase each other's negative side effects such as nausea, dizziness, and loss of consciousness. Caution is advised for beyond medical dosages due to seizure concerns, and medical dosages for individuals with higher risk seizure profiles and or behavior.

来源

author

Anwar, S., Cooper, J., Rahman, J., Sharma, C., & Langford, R. (2019)

标题

Prolonged Perioperative Use of Pregabalin and Ketamine to Prevent Persistent Pain after Cardiac Surgery. Anesthesiology, 131(1), 119–131.

链接

https://doi.org/10.1097/ALN.0000000000002751

author

Arendt-Nielsen, L., Mansikka, H., Staahl, C., Rees, H., Tan, K., Smart, T. S., Monhemius, R., Suzuki, R., & Drewes, A. M. (2011)

标题

A Translational Study of the Effects of Ketamine and Pregabalin on Temporal Summation of Experimental Pain. Regional Anesthesia & Pain Medicine, 36(6), 585–591.

链接

https://doi.org/10.1097/AAP.0b013e31822b0db0

author

Az, A., & Doğan, Y. (2024)

标题

Unexpected consequences: A case of ketamine‑induced seizure in procedural sedation. Turkish Journal of Emergency Medicine, 24(4), 259–261.

链接

https://doi.org/10.4103/tjem.tjem_67_24

author

Barker-Haliski, M., & White, H. S. (2015)

标题

Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.

链接

https://doi.org/10.1101/cshperspect.a022863

author

Ben‐Menachem, E. (2004)

标题

Pregabalin Pharmacology and Its Relevance to Clinical Practice. Epilepsia, 45(s6), 13–18.

链接

https://doi.org/10.1111/j.0013-9580.2004.455003.x

author

French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)

标题

Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial. Neurology, 82(7), 590–597.

链接

https://doi.org/10.1212/WNL.0000000000000119

author

Gayatri, N., & Livingston, J. (2006)

标题

Aggravation of epilepsy by anti‐epileptic drugs. Developmental Medicine & Child Neurology, 48(5), 394–398.

链接

https://doi.org/10.1017/S0012162206000843

author

Hitchings, A. W. (2016)

标题

Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.

链接

https://doi.org/10.1097/FAD.0000000000000016

author

Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)

标题

Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.

链接

https://doi.org/10.1111/bcp.14348

author

Kim, J. H., Lee, C. K., Yu, S. H., Min, B. D., Chung, C. E., & Kim, D. C. (2021)

标题

Ketamine-induced generalized convulsive seizure during procedural sedation. Archives of Craniofacial Surgery, 22(2), 119–121.

链接

https://doi.org/10.7181/acfs.2021.00094

author

Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)

标题

Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.

链接

https://doi.org/10.1111/j.1471-4159.2010.06625.x

author

Martinez, V., Cymerman, A., Ben Ammar, S., Fiaud, J. F., Rapon, C., Poindessous, F., Judet, T., Chauvin, M., Bouhassira, D., Sessler, D., Mazoit, X., & Fletcher, D. (2014)

标题

The analgesic efficiency of combined pregabalin and ketamine for total hip arthroplasty: a randomised, double‐blind, controlled study. Anaesthesia, 69(1), 46–52.

链接

https://doi.org/10.1111/anae.12495

author

Shehata, I. M., Kohaf, N. A., ElSayed, M. W., Latifi, K., Aboutaleb, A. M., & Kaye, A. D. (2024)

标题

Ketamine: Pro or antiepileptic agent? A systematic review. Heliyon, 10(2), e24433.

链接

https://doi.org/10.1016/j.heliyon.2024.e24433

author

Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)

标题

Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.

链接

https://doi.org/10.1080/24734306.2018.1458465

author

Zhou, Y., Sun, W., Fu, Y., Wang, J., Fan, J., Liang, Y., Jia, W., & Han, R. (2024)

标题

Effect of esketamine combined with pregabalin on acute postsurgical pain in patients who underwent resection of spinal neoplasms: a randomized controlled trial. Pain, 165(9), e96–e105.

链接

https://doi.org/10.1097/j.pain.0000000000003211

风险等级

谨慎 （Caution）

物质 A

氯胺酮

物质 B

pregabalin