TripSit · diphenhydramine + tramadol

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

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备注

这两种药物都会增加血清素综合征的风险。在医疗剂量下，这不太可能引起关注，但应避免娱乐剂量。苯海拉明可能会增加曲马多癫痫发作的风险。

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Both drugs increase the risk of serotonin syndrome. While at medical dosages, this is unlikely to be of concern, recreational doses should be avoided. Diphenhydramine may increase tramadol’s seizure risk.

来源

author

Benson, B. E., Farooqi, M. F., Klein-Schwartz, W., Litovitz, T., Webb, A. N., Borys, D. J., Lung, D., Rutherfoord Rose, S., Aleguas, A., Sollee, D. R., & Seifert, S. A. (2010)

标题

Diphenhydramine dose–response: a novel approach to determine triage thresholds. Clinical Toxicology, 48(8), 820–831.

链接

https://doi.org/10.3109/15563650.2010.514269

author

Dhesi, M., Maldonado, K. A., Patel, P., & Maani, C. V. (2025)

标题

Tramadol. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK537060/

author

Hughes, A. R., Lin, A., Hendrickson, R. G., & on behalf of Toxicology Investigator’s Consortium (ToxIC). (2021)

标题

Clinical and patient characteristics associated with severe outcome in diphenhydramine toxicity. Clinical Toxicology, 59(10), 918–925.

链接

https://doi.org/10.1080/15563650.2021.1891244

author

Khan, S., Saud, S., Khan, I., Asif, M., Ismail, O., Salam, A., Yang, T. J., & Norville, K. J. (2018)

标题

Serotonin Syndrome Presenting with Concomitant Tramadol and Diphenhydramine Use: A Case Report of an Unlikely Side-Effect. Cureus.

链接

https://doi.org/10.7759/cureus.2421

author

Kim, H., Kim, S. H., & Kim, J. B. (2021)

标题

Antihistamines as a common cause of new-onset seizures: a single-center observational study. Neurological Sciences: Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 42(6), 2505–2508.

链接

https://doi.org/10.1007/s10072-021-05043-2

author

Kim, H., Wang, I.-N., Park, J.-S., Kim, K.-T., Kong, J., Kim, J. B., & Kim, D.-J. (2023)

标题

Inherent seizure susceptibility in patients with antihistamine-induced acute symptomatic seizure: a resting-state EEG analysis. Scientific Reports, 13(1), 9146.

链接

https://doi.org/10.1038/s41598-023-36415-7

author

Sanaei-Zadeh, H. (2012)

标题

Diphenhydramine overdose and serotonin syndrome. Psychiatry and Clinical Neurosciences, 66(3), 244–245.

链接

https://doi.org/10.1111/j.1440-1819.2012.02320.x

author

Sicari, V., Patel, P., & Zabbo, C. P. (2025)

标题

Diphenhydramine. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK526010/

风险等级

危险（应避免） （Dangerous）

物质 A

diphenhydramine

物质 B

曲马多