TripSit · Lithium

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

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相互作用

2c-t-x

备注

有大量报告表明这种组合具有较高的癫痫和精神病风险。

查看原文

There are a large number of reports indicating a high seizure and psychosis risk from this combination.

来源

author

Sandeep M Nayak, Natalie Gukasyan, Frederick S Barrett , Earth Erowid , Fire Erowid , Roland R Griffiths

标题

Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports

链接

https://doi.org/10.1055/a-1524-2794

author

Erowid

标题

Erowid Interactions

链接

https://erowid.org/chemicals/lsd/lsd_interactions.shtml

author

freshboi88

标题

I Was Only on One Dose

链接

https://erowid.org/experiences/exp.php?ID=93681

author

YouWerentYouAnymore

标题

Brought My Worst Thoughts to Life

链接

https://erowid.org/experiences/exp.php?ID=110780

author

Otto Simonsson, Peper S. Hendricks, Richard Chambers, Walter Osika, Simon B. Goldberg

标题

Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics

链接

https://doi.org/10.1016/j.jad.2023.01.073

风险等级

危险（应避免） （Dangerous）

2c-x

备注

有大量报告表明这种组合具有较高的癫痫和精神病风险。

查看原文

There are a large number of reports indicating a high seizure and psychosis risk from this combination.

来源

author

Sandeep M Nayak, Natalie Gukasyan, Frederick S Barrett , Earth Erowid , Fire Erowid , Roland R Griffiths

标题

Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports

链接

https://doi.org/10.1055/a-1524-2794

author

Erowid

标题

Erowid Interactions

链接

https://erowid.org/chemicals/lsd/lsd_interactions.shtml

author

freshboi88

标题

I Was Only on One Dose

链接

https://erowid.org/experiences/exp.php?ID=93681

author

YouWerentYouAnymore

标题

Brought My Worst Thoughts to Life

链接

https://erowid.org/experiences/exp.php?ID=110780

author

Otto Simonsson, Peper S. Hendricks, Richard Chambers, Walter Osika, Simon B. Goldberg

标题

Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics

链接

https://doi.org/10.1016/j.jad.2023.01.073

风险等级

危险（应避免） （Dangerous）

cocaine

备注

锂可能会抑制可卡因的一些娱乐作用。

查看原文

Lithium may inhibit some of the recreational effects of cocaine.

来源

author

Flemenbaum, A.

标题

Antagonism of behavioral effects of cocaine by lithium. (1977)

链接

https://doi.org/10.1016/0091-3057(77)90015-6

author

Cronson, A. J., & Flemenbaum, A.

标题

Antagonism of Cocaine Highs by Lithium. (1981)

链接

https://doi.org/10.1007/978-1-4684-3614-3_132

风险等级

Low Risk & Decrease

dextromethorphan

备注

将锂与 DXM 结合使用时，存在发生血清素综合征的风险。

查看原文

There is a risk of serotonin syndrome when combining Lithium with DXM.

来源

author

Lenox, R. H., & Hahn, C. G.

标题

Overview of the mechanism of action of lithium in the brain: fifty-year update (2000)

链接

https://pubmed.ncbi.nlm.nih.gov/10826655/

author

Shahani, L.

标题

Venlafaxine Augmentation With Lithium Leading to Serotonin Syndrome (2012)

链接

https://doi.org/10.1176/appi.neuropsych.11080196

author

DeBattista, C., Sofuoglu, M., & Schatzberg, A. F.

标题

Serotonergic synergism: the risks and benefits of combining the selective serotonin reuptake inhibitors with other serotonergic drugs (1998)

链接

https://doi.org/10.1016/s0006-3223(98)00161-9

author

Massot, O.

标题

5-HT1B Receptors: A Novel Target for Lithium: Possible Involvement in Mood Disorders (1999)

链接

https://doi.org/10.1016/S0893-133X(99)00042-1

author

Navarro, A., Perry, C., & Bobo, W. V.

标题

A case of serotonin syndrome precipitated by abuse of the anticough remedy dextromethorphan in a bipolar patient treated with fluoxetine and lithium. (2006)

链接

https://doi.org/10.1016/j.genhosppsych.2005.06.008

风险等级

危险（应避免） （Dangerous）

diphenhydramine

备注

较高剂量的这种组合可能会导致血清素综合征。建议谨慎限制苯海拉明的医疗剂量（25-50 毫克）。锂盐和苯海拉明都有 QT 延长的风险，联合服用时可能会增加 QT 延长；由于使用者的健康和药物剂量等多种因素，风险会增加。此外，组合可能会增加每种药物的副作用，例如头晕和意识丧失。

查看原文

There is a concern of serotonin syndrome at higher dosages of this combination. Caution is recommended in restricting diphenhydramine to medical dosages (25-50mg). Lithium and diphenhydramine both have concerns of QT prolongation which may be increased when taken in combination; risks increase due to a variety of factors such as the health of the user and drug dosages. Additionally, the combination may increase each drug's side effects, such as dizziness and loss of consciousness.

来源

author

Clark, J. H., Meltzer, E. O., & Naclerio, R. M.

标题

Diphenhydramine: It is time to say a final goodbye. World Allergy Organization Journal, 18(2), 101027. (2025)

链接

https://doi.org/10.1016/j.waojou.2025.101027

author

Crouch, M. A., Limon, L., & Cassano, A. T.

标题

Clinical Relevance and Management of Drug‐Related QT Interval Prolongation. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 23(7), 881–908. (2003)

链接

https://doi.org/10.1592/phco.23.7.881.32730

author

Farzam, K., & Tivakaran, V. S.

标题

QT Prolonging Drugs. In StatPearls. StatPearls Publishing. (2025)

链接

http://www.ncbi.nlm.nih.gov/books/NBK534864/

author

Finley, P. R.

标题

Drug Interactions with Lithium: An Update. Clinical Pharmacokinetics, 55(8), 925–941. (2016)

链接

https://doi.org/10.1007/s40262-016-0370-y

author

Hawley, C. J., Loughlin, P. J., Quick, S. J., Gale, T. M., Sivakumaran, T., Hayes, J., & McPhee, S.

标题

Efficacy, safety and tolerability of combined administration of lithium and selective serotonin reuptake inhibitors: a review of the current evidence. International Clinical Psychopharmacology, 15(4), 197–206. (2000)

链接

https://doi.org/10.1097/00004850-200015040-00002

author

Husain, Z., Hussain, K., Nair, R., & Steinman, R.

标题

Diphenhydramine induced QT prolongation and torsade de pointes: An uncommon effect of a common drug. Cardiology Journal, 17(5), 509–511. (2010)

链接

https://journals.viamedica.pl/cardiology_journal/article/view/21341

author

Khan, S., Saud, S., Khan, I., Asif, M., Ismail, O., Salam, A., Yang, T. J., & Norville, K. J.

标题

Serotonin Syndrome Presenting with Concomitant Tramadol and Diphenhydramine Use: A Case Report of an Unlikely Side-Effect. Cureus. (2018)

链接

https://doi.org/10.7759/cureus.2421

author

Massot, O., Rousselle, J.-C., Fillion, M.-P., Januel, D., Plantefol, M., & Fillion, G.

标题

5-HT1B Receptors: A Novel Target for Lithium: Possible Involvement in Mood Disorders. Neuropsychopharmacology, 21(4), 530–541. (1999)

链接

https://doi.org/10.1016/S0893-133X(99)00042-1

author

Mehta, N., & Vannozzi, R.

标题

Lithium‐induced electrocardiographic changes: A complete review. Clinical Cardiology, 40(12), 1363–1367. (2017)

链接

https://doi.org/10.1002/clc.22822

author

Müller-Oerlinghausen, B.

标题

Drug Interactions with Lithium: A Guide for Clinicians. CNS Drugs, 11(1), 41–48. (1999)

链接

https://doi.org/10.2165/00023210-199911010-00004

author

Rosenberg, A. E., Wang, R., & Rosenberg, M. H.

标题

Serotonin Syndrome Associated With High-dose Diphenhydramine Use Complicating Abdominoplasty and Mastopexy. Plastic and Reconstructive Surgery - Global Open, 13(3), e6634. (2025)

链接

https://doi.org/10.1097/GOX.0000000000006634

author

Truedson, P., Ott, M., Lindmark, K., Ström, M., Maripuu, M., Lundqvist, R., & Werneke, U.

标题

Effects of Toxic Lithium Levels on ECG—Findings from the LiSIE Retrospective Cohort Study. Journal of Clinical Medicine, 11(19), 5941. (2022)

链接

https://doi.org/10.3390/jcm11195941

风险等级

谨慎 （Caution）

dmt

备注

有大量报告表明这种组合具有较高的癫痫和精神病风险。

查看原文

There are a large number of reports indicating a high seizure and psychosis risk from this combination.

来源

author

Sandeep M Nayak, Natalie Gukasyan, Frederick S Barrett , Earth Erowid , Fire Erowid , Roland R Griffiths

标题

Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports

链接

https://doi.org/10.1055/a-1524-2794

author

Erowid

标题

Erowid Interactions

链接

https://erowid.org/chemicals/lsd/lsd_interactions.shtml

author

freshboi88

标题

I Was Only on One Dose

链接

https://erowid.org/experiences/exp.php?ID=93681

author

YouWerentYouAnymore

标题

Brought My Worst Thoughts to Life

链接

https://erowid.org/experiences/exp.php?ID=110780

author

Otto Simonsson, Peper S. Hendricks, Richard Chambers, Walter Osika, Simon B. Goldberg

标题

Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics

链接

https://doi.org/10.1016/j.jad.2023.01.073

风险等级

危险（应避免） （Dangerous）

dox

备注

有大量报告表明这种组合具有较高的癫痫和精神病风险。

查看原文

There are a large number of reports indicating a high seizure and psychosis risk from this combination.

来源

author

Sandeep M Nayak, Natalie Gukasyan, Frederick S Barrett , Earth Erowid , Fire Erowid , Roland R Griffiths

标题

Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports

链接

https://doi.org/10.1055/a-1524-2794

author

Erowid

标题

Erowid Interactions

链接

https://erowid.org/chemicals/lsd/lsd_interactions.shtml

author

freshboi88

标题

I Was Only on One Dose

链接

https://erowid.org/experiences/exp.php?ID=93681

author

YouWerentYouAnymore

标题

Brought My Worst Thoughts to Life

链接

https://erowid.org/experiences/exp.php?ID=110780

author

Otto Simonsson, Peper S. Hendricks, Richard Chambers, Walter Osika, Simon B. Goldberg

标题

Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics

链接

https://doi.org/10.1016/j.jad.2023.01.073

风险等级

危险（应避免） （Dangerous）

ketamine

备注

锂可以增强和延长氯胺酮的抗抑郁作用。

查看原文

Lithium may enhance and prolong the antidepressant effects of ketamine.

来源

author

Costi, S., Soleimani, L., Glasgow, A., Brallier, J., Spivack, J., Schwartz, J., Levitch, C. F., Richards, S., Hoch, M., Stade, E. C., Welch, A., Collins, K. A., Feder, A., Iosifescu, D. V., Charney, D. S., & Murrough, J. W. (2019)

标题

Lithium continuation therapy following ketamine in patients with treatment resistant unipolar depression: a randomized controlled trial. Neuropsychopharmacology, 44(10), 1812–1819.

链接

https://doi.org/10.1038/s41386-019-0365-0

author

Diazgranados, N., Ibrahim, L., Brutsche, N. E., Newberg, A., Kronstein, P., Khalife, S., Kammerer, W. A., Quezado, Z., Luckenbaugh, D. A., Salvadore, G., Machado-Vieira, R., Manji, H. K., & Zarate, C. A. (2010)

标题

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression. Archives of General Psychiatry, 67(8), 793.

链接

https://doi.org/10.1001/archgenpsychiatry.2010.90

author

Price, J. B., Yates, C. G., Morath, B. A., Van De Wakker, S. K., Yates, N. J., Butters, K., Frye, M. A., McGee, S. L., & Tye, S. J. (2021)

标题

Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression. Translational Psychiatry, 11(1), 1–12.

链接

https://doi.org/10.1038/s41398-021-01716-w

author

Scheuing, L., Chiu, C.-T., Liao, H.-M., & Chuang, D.-M. (2015)

标题

Antidepressant mechanism of ketamine: perspective from preclinical studies. Frontiers in Neuroscience, 9.

链接

https://doi.org/10.3389/fnins.2015.00249

author

Toulany, J., Cunningham, J. E. A., & Nunes, A. (2025)

标题

Overlap and Divergence in Ketamine and Lithium Response in Bipolar Disorder: A Scoping Review. Pharmaceuticals, 18(11), 1662.

链接

https://doi.org/10.3390/ph18111662

author

Wilkowska, A., Szałach, Ł., & Cubała, W. J. (2020)

标题

Ketamine in Bipolar Disorder: A Review. Neuropsychiatric Disease and Treatment, 16, 2707–2717.

链接

https://doi.org/10.2147/NDT.S282208

风险等级

Low Risk & No Synergy

lithium

备注

将锂与 MXE 联合使用时，存在发生血清素综合征的风险，因为锂与其他血清素能药物一起使用可诱发血清素综合征，而 MXE 对血清素转运蛋白表现出显着的亲和力。

查看原文

There is a risk of serotonin syndrome when combining Lithium with MXE, as Lithium can induce serotonin syndrome in conjunction with other serotonergic drugs, and MXE has shown a notable affinity for the serotonin transporter.

来源

author

Lenox, R. H., & Hahn, C. G.

标题

Overview of the mechanism of action of lithium in the brain: fifty-year update (2000)

链接

https://pubmed.ncbi.nlm.nih.gov/10826655/

author

Shahani, L.

标题

Venlafaxine Augmentation With Lithium Leading to Serotonin Syndrome (2012)

链接

https://doi.org/10.1176/appi.neuropsych.11080196

author

DeBattista, C., Sofuoglu, M., & Schatzberg, A. F.

标题

Serotonergic synergism: the risks and benefits of combining the selective serotonin reuptake inhibitors with other serotonergic drugs (1998)

链接

https://doi.org/10.1016/S0006-3223(98)00161-9

author

Massot, O.

标题

5-HT1B Receptors: A Novel Target for Lithium: Possible Involvement in Mood Disorders (1999)

链接

https://doi.org/10.1016/S0893-133X(99)00042-1

author

Roth, B. L., Gibbons, S., Arunotayanun, W., Huang, X.-P., Setola, V., Treble, R., & Iversen, L.

标题

The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor (2013)

链接

https://doi.org/10.1371/journal.pone.0059334

author

Marti, M., Talani, G., Miliano, C., Bilel, S., Biggio, F., Bratzu, J., Diana, M., De Luca, M. A., & Fattore, L.

标题

New insights into methoxetamine mechanisms of action: Focus on serotonergic 5-HT2 receptors in pharmacological and behavioral effects in the rat (2021)

链接

https://doi.org/10.1016/j.expneurol.2021.113836

风险等级

危险（应避免） （Dangerous）

lsd

备注

有大量报告表明这种组合具有较高的癫痫和精神病风险。

查看原文

There are a large number of reports indicating a high seizure and psychosis risk from this combination.

来源

author

Sandeep M Nayak, Natalie Gukasyan, Frederick S Barrett , Earth Erowid , Fire Erowid , Roland R Griffiths

标题

Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports

链接

https://doi.org/10.1055/a-1524-2794

author

Erowid

标题

Erowid Interactions

链接

https://erowid.org/chemicals/lsd/lsd_interactions.shtml

author

freshboi88

标题

I Was Only on One Dose

链接

https://erowid.org/experiences/exp.php?ID=93681

author

YouWerentYouAnymore

标题

Brought My Worst Thoughts to Life

链接

https://erowid.org/experiences/exp.php?ID=110780

author

Otto Simonsson, Peper S. Hendricks, Richard Chambers, Walter Osika, Simon B. Goldberg

标题

Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics

链接

https://doi.org/10.1016/j.jad.2023.01.073

author

Edwards, C., Van Gerpen, S., & Anand, V.

标题

New-Onset Seizures in an Adolescent Following Use of LSD while on Low-Dose Lithium Therapy: A Case Study. (2024)

链接

https://doi.org/10.1177%2F1941874414528939

风险等级

危险（应避免） （Dangerous）

mdma

备注

血清素综合征的高风险

查看原文

High risk of serotonin syndrome

来源

author

Lokesh Shahani

标题

Venlafaxine Augmentation With Lithium Leading to Serotonin Syndrome

链接

https://doi.org/10.1176/appi.neuropsych.11080196

author

Charles DeBattista, Mehmet Sofuoglu, and Alan F. Schatzberg

标题

Serotonergic Synergism: The Risks and Benefits of Combining the Selective Serotonin Reuptake Inhibitors with Other Serotonergic Drugs

链接

https://www.biologicalpsychiatryjournal.com/article/S0006-3223(98)00161-9/pdf

author

Olivier Massot Ph.D, Jean-Claude Rousselle Ph.D, Marie-Paule Fillion MSc, Dominique Januel MD, Mathieu Plantefol MSc & Gilles Fillion Ph.D

标题

5-HT1B Receptors: A Novel Target for Lithium: Possible Involvement in Mood Disorders

链接

https://doi.org/10.1016/S0893-133X(99)00042-1

author

Philip J. Cowen

标题

New drugs, old problems: Revisiting… Pharmacological management of treatment-resistant depression

链接

https://doi.org/10.1192/apt.11.1.19

风险等级

危险（应避免） （Dangerous）

mescaline

备注

有大量报告表明这种组合具有较高的癫痫和精神病风险。

查看原文

There are a large number of reports indicating a high seizure and psychosis risk from this combination.

来源

author

Sandeep M Nayak, Natalie Gukasyan, Frederick S Barrett , Earth Erowid , Fire Erowid , Roland R Griffiths

标题

Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports

链接

https://doi.org/10.1055/a-1524-2794

author

Erowid

标题

Erowid Interactions

链接

https://erowid.org/chemicals/lsd/lsd_interactions.shtml

author

freshboi88

标题

I Was Only on One Dose

链接

https://erowid.org/experiences/exp.php?ID=93681

author

YouWerentYouAnymore

标题

Brought My Worst Thoughts to Life

链接

https://erowid.org/experiences/exp.php?ID=110780

author

Otto Simonsson, Peper S. Hendricks, Richard Chambers, Walter Osika, Simon B. Goldberg

标题

Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics

链接

https://doi.org/10.1016/j.jad.2023.01.073

风险等级

危险（应避免） （Dangerous）

mushrooms

备注

有大量报告表明这种组合具有较高的癫痫和精神病风险。

查看原文

There are a large number of reports indicating a high seizure and psychosis risk from this combination.

来源

author

Sandeep M Nayak, Natalie Gukasyan, Frederick S Barrett , Earth Erowid , Fire Erowid , Roland R Griffiths

标题

Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports

链接

https://doi.org/10.1055/a-1524-2794

author

Erowid

标题

Erowid Interactions

链接

https://erowid.org/chemicals/lsd/lsd_interactions.shtml

author

freshboi88

标题

I Was Only on One Dose

链接

https://erowid.org/experiences/exp.php?ID=93681

author

YouWerentYouAnymore

标题

Brought My Worst Thoughts to Life

链接

https://erowid.org/experiences/exp.php?ID=110780

author

Otto Simonsson, Peper S. Hendricks, Richard Chambers, Walter Osika, Simon B. Goldberg

标题

Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics

链接

https://doi.org/10.1016/j.jad.2023.01.073

风险等级

危险（应避免） （Dangerous）

mxe

备注

将锂与 MXE 联合使用时，存在发生血清素综合征的风险，因为锂与其他血清素能药物一起使用可诱发血清素综合征，而 MXE 对血清素转运蛋白表现出显着的亲和力。

查看原文

There is a risk of serotonin syndrome when combining Lithium with MXE, as Lithium can induce serotonin syndrome in conjunction with other serotonergic drugs, and MXE has shown a notable affinity for the serotonin transporter.

来源

author

Lenox, R. H., & Hahn, C. G.

标题

Overview of the mechanism of action of lithium in the brain: fifty-year update (2000)

链接

https://pubmed.ncbi.nlm.nih.gov/10826655/

author

Shahani, L.

标题

Venlafaxine Augmentation With Lithium Leading to Serotonin Syndrome (2012)

链接

https://doi.org/10.1176/appi.neuropsych.11080196

author

DeBattista, C., Sofuoglu, M., & Schatzberg, A. F.

标题

Serotonergic synergism: the risks and benefits of combining the selective serotonin reuptake inhibitors with other serotonergic drugs (1998)

链接

https://doi.org/10.1016/S0006-3223(98)00161-9

author

Massot, O.

标题

5-HT1B Receptors: A Novel Target for Lithium: Possible Involvement in Mood Disorders (1999)

链接

https://doi.org/10.1016/S0893-133X(99)00042-1

author

Roth, B. L., Gibbons, S., Arunotayanun, W., Huang, X.-P., Setola, V., Treble, R., & Iversen, L.

标题

The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor (2013)

链接

https://doi.org/10.1371/journal.pone.0059334

author

Marti, M., Talani, G., Miliano, C., Bilel, S., Biggio, F., Bratzu, J., Diana, M., De Luca, M. A., & Fattore, L.

标题

New insights into methoxetamine mechanisms of action: Focus on serotonergic 5-HT2 receptors in pharmacological and behavioral effects in the rat (2021)

链接

https://doi.org/10.1016/j.expneurol.2021.113836

风险等级

危险（应避免） （Dangerous）

nbomes

备注

有大量报告表明这种组合具有较高的癫痫和精神病风险。

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There are a large number of reports indicating a high seizure and psychosis risk from this combination.

来源

author

Sandeep M Nayak, Natalie Gukasyan, Frederick S Barrett , Earth Erowid , Fire Erowid , Roland R Griffiths

标题

Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports

链接

https://doi.org/10.1055/a-1524-2794

author

Erowid

标题

Erowid Interactions

链接

https://erowid.org/chemicals/lsd/lsd_interactions.shtml

author

freshboi88

标题

I Was Only on One Dose

链接

https://erowid.org/experiences/exp.php?ID=93681

author

YouWerentYouAnymore

标题

Brought My Worst Thoughts to Life

链接

https://erowid.org/experiences/exp.php?ID=110780

author

Otto Simonsson, Peper S. Hendricks, Richard Chambers, Walter Osika, Simon B. Goldberg

标题

Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics

链接

https://doi.org/10.1016/j.jad.2023.01.073

author

Umemura, Y., Andrew, T. A., Jacobs, V. L., Giustini, A. J., Lewis, L. D., & Filiano, J. J.

标题

Fatal 251-NBOMe Intoxication: A New Recreational Risk. (2015)

链接

https://doi.org/10.23907/2015.009

风险等级

危险（应避免） （Dangerous）

nitrous

备注

我们无法找到有关锂引起中枢神经系统抑制的报告。

查看原文

We are unable to find a report of concerns for CNS depression caused by Lithium.

来源

author

Drugbank

标题

Lithium Carbonate

链接

https://go.drugbank.com/drugs/DB14509

风险等级

Low Risk & No Synergy

ssris

备注

这种交互用于医疗环境，没有报告问题。如果采用这种组合，如果计划在这些可能具有血清素活性的药物之上服用任何其他药物，则建议谨慎。

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This interaction is used in medical settings without reported issues. If this combination is taken, caution would be recommended if any other drugs are planned to be taken on top of these that may have serotonergic activity.

来源

author

Finley, P. R.

标题

Drug Interactions with Lithium: An Update. (2016)

链接

https://doi.org/10.1007/s40262-016-0370-y

author

Hawley CJ, Loughlin PJ, Quick SJ, Gale TM, Sivakumaran T, Hayes J, McPhee S.

标题

Efficacy, safety and tolerability of combined administration of lithium and selective serotonin reuptake inhibitors: a review of the current evidence. (2000)

链接

https://doi.org/10.1097/00004850-200015040-00002

author

Müller-Oerlinghausen, B.

标题

Drug Interactions with Lithium. (1999)

链接

https://doi.org/10.2165/00023210-199911010-00004

author

Bauer, Michael PhD, MD; Linden, Michael MD; Schaaf, Berthold; Weber, Hans J. MD.

标题

Adverse Events and Tolerability of the Combination of Fluoxetine/Lithium Compared With Fluoxetine. (1996)

链接

https://doi.org/10.1097/00004714-199604000-00005

风险等级

Low Risk & No Synergy

tramadol

备注

曲马多和锂都会增加癫痫发作和血清素综合征的风险。

查看原文

Tramadol and Lithium both increase the risk of seizures and serotonin syndrome.

来源

author

Steven C. Julius, Richard P. Brenner

标题

Myoclonic seizures with lithium

链接

https://doi.org/10.1016/0006-3223(87)90026-6

author

Charles DeBattista, Mehmet Sofuoglu, and Alan F. Schatzberg

标题

Serotonergic Synergism: The Risks and Benefits of Combining the Selective Serotonin Reuptake Inhibitors with Other Serotonergic Drugs

链接

https://doi.org/10.1016/s0006-3223(98)00161-9

author

Massot, O., Rousselle, JC., Fillion, MP. et al.

标题

5-HT1B Receptors: A Novel Target for Lithium: Possible Involvement in Mood Disorders

链接

https://doi.org/10.1016/S0893-133X(99)00042-1

author

Sameer Hassamal, Karen Miotto, William Dale, Itai Danovitch

标题

Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures

链接

https://doi.org/10.1016/j.amjmed.2018.04.025

author

Boostani R, Derakhshan S.

标题

Tramadol induced seizure: A 3-year study.

链接

https://pubmed.ncbi.nlm.nih.gov/24009919/

author

Lagard, C.; Vodovar, D.; Chevillard, L.; Callebert, J.; Caillé, F.; Pottier, G.; Liang, H.; Risède, P.; Tournier, N.; Mégarbane, B.

标题

Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat

链接

https://doi.org/10.3390/ph15101254

author

Sansone RA, Sansone LA.

标题

曲马多

链接

https://pubmed.ncbi.nlm.nih.gov/19724727

风险等级

危险（应避免） （Dangerous）

名称

锂盐

通用名

锂盐