TripSit · cocaine + pregabalin

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

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这种组合存在癫痫发作的显着风险。兴奋剂会增加呼吸频率，从而允许使用比正常剂量更高的镇静剂。如果可卡因首先消失，娱乐性剂量的普瑞巴林可能会抑制个体并导致呼吸停止。这两种物质在娱乐剂量下都会使心脏紧张，并可能导致进一步危险的心脏并发症。当组合更高剂量时，该组合具有更大的高铁血红蛋白血症风险。

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There is a significant risk of seizures from this combination. Stimulants increase respiration rate, allowing for a higher dose of sedatives than normal. If cocaine wears off first, recreational dosages of pregabalin may overcome the individual and cause respiratory arrest. Both substances at recreational dosages strain the heart and may lead to further dangerous heart complications. The combination has a greater risk of methemoglobinemia when higher dosages are combined.

来源

author

Altair. (n.d.-a)

标题

Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure: Not Recreational.”

链接

https://www.erowid.org/experiences/exp.php?ID=69917

author

Barker-Haliski, M., & White, H. S. (2015)

标题

Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.

链接

https://doi.org/10.1101/cshperspect.a022863

author

Ben-Menachem, E. (2004)

标题

Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.

链接

https://doi.org/10.1111/j.0013-9580.2004.455003.x

author

Douke, R. (n.d.)

标题

Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”

链接

https://www.erowid.org/experiences/exp.php?ID=83232

author

French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)

标题

Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.

链接

https://doi.org/10.1212/WNL.0000000000000119

author

Gayatri, N. A., & Livingston, J. H. (2006)

标题

Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.

链接

https://doi.org/10.1017/S0012162206000843

author

Hitchings, A. W. (2016)

标题

Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.

链接

https://doi.org/10.1097/FAD.0000000000000016

author

Hunter, L., Gordge, L., Dargan, P. I., & Wood, D. M. (2011)

标题

Methaemoglobinaemia associated with the use of cocaine and volatile nitrites as recreational drugs: a review. British Journal of Clinical Pharmacology, 72(1), 18–26.

链接

https://doi.org/10.1111/j.1365-2125.2011.03950.x

author

Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)

标题

Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.

链接

https://doi.org/10.1111/bcp.14348

author

Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)

标题

Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.

链接

https://doi.org/10.1111/j.1471-4159.2010.06625.x

author

Lappin, J. M., & Sara, G. E. (2019)

标题

Psychostimulant use and the brain. Addiction, 114(11), 2065–2077.

链接

https://doi.org/10.1111/add.14708

author

Ludlow, J. T., Wilkerson, R. G., & Nappe, T. M. (2025)

标题

Methemoglobinemia. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK537317/

author

Pergolizzi, J. V., Magnusson, P., LeQuang, J. A. K., Breve, F., & Varrassi, G. (n.d.)

标题

Cocaine and Cardiotoxicity: A Literature Review. Cureus, 13(4), e14594.

链接

https://doi.org/10.7759/cureus.14594

author

Sean. (n.d.-b)

标题

Pregabalin - Erowid Exp - “Stay Away.”

链接

https://www.erowid.org/experiences/exp.php?ID=67302

author

Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)

标题

Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.

链接

https://doi.org/10.1080/24734306.2018.1458465

风险等级

不安全 （Unsafe）

物质 A

可卡因

物质 B

pregabalin