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TripSit · Pregabalin

TripSit 参考资料 · 药物资料 2026-10-23

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正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

详情

别名

lyrica pregablin

分类

抑制剂习惯形成常规

相互作用

2c-x

备注

普瑞巴林可以减少 2C-X 药物的焦虑和其他可能的副作用。此外，这种组合可能会增加抑制、头晕和受伤的风险。

查看原文

Pregabalin may reduce the anxiety and other possible side effects of 2C-X drugs. Additionally, the combination may increase inhibition, dizziness, and risk of injury.

来源

author: Cross, A. L., Viswanath, O., & Sherman, A. L. (2025)
标题: Pregabalin. In StatPearls. StatPearls Publishing.
链接: http://www.ncbi.nlm.nih.gov/books/NBK470341/

author: Gil-Martins, E., Barbosa, D. J., Borges, F., Remião, F., & Silva, R. (2025)
标题: Toxicodynamic insights of 2C and NBOMe drugs – Is there abuse potential? Toxicology Reports, 14, 101890.
链接: https://doi.org/10.1016/j.toxrep.2025.101890

风险等级

低风险 · 协同（Low Risk & Synergy）

5-meo-xxt

备注

由于 5-MeO-xxT 药物的刺激作用和高剂量普瑞巴林的癫痫发作问题，应谨慎使用。普瑞巴林可以减少 5-MeO-xxT 药物的血管收缩、焦虑和其他副作用。此外，普瑞巴林可能会增加 5-MeO-xxT 药物抑制和受伤风险。

查看原文

Caution should be given due to 5-MeO-xxT drugs stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the vasoconstriction, anxiety, and other side effects of 5-MeO-xxT drugs. Additionally, Pregabalin may increase 5-MeO-xxT drugs inhibition and risk of injury.

来源

author: Altair. (n.d.-a)
标题: Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
链接: https://www.erowid.org/experiences/exp.php?ID=69917

author: Altuncı, Y. A., Aydoğdu, M., Açıkgöz, E., Güven, Ü., Düzağaç, F., Atasoy, A., Dağlıoğlu, N., & Akgür, S. A. (2021)
标题: New Psychoactive Substance 5-MeO-MiPT In vivo Acute Toxicity and Hystotoxicological Study. Balkan Medical Journal, 38(1), 34–42.
链接: https://doi.org/10.4274/balkanmedj.galenos.2020.2019.11.68

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Ben-Menachem, E. (2004)
标题: Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Douke, R. (n.d.)
标题: Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
链接: https://www.erowid.org/experiences/exp.php?ID=83232

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N. A., & Livingston, J. H. (2006)
标题: Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Reckweg, J. T., Uthaug, M. V., Szabo, A., Davis, A. K., Lancelotta, R., Mason, N. L., & Ramaekers, J. G. (2022)
标题: The clinical pharmacology and potential therapeutic applications of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT). Journal of Neurochemistry, 162(1), 128–146.
链接: https://doi.org/10.1111/jnc.15587

author: Rickli, A., Moning, O. D., Hoener, M. C., & Liechti, M. E. (2016)
标题: Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 26(8), 1327–1337.
链接: https://doi.org/10.1016/j.euroneuro.2016.05.001

author: Sean. (n.d.-b)
标题: Pregabalin - Erowid Exp - “Stay Away.”
链接: https://www.erowid.org/experiences/exp.php?ID=67302

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

author: Soto-Angona, Ó., Fortea, A., Fortea, L., Martínez-Ramírez, M., Santamarina, E., López, F. J. G., Knudsen, G. M., & Ona, G. (2024)
标题: Do classic psychedelics increase the risk of seizures? A scoping review. European Neuropsychopharmacology, 85, 35–42.
链接: https://doi.org/10.1016/j.euroneuro.2024.05.002

风险等级

谨慎（Caution）

amphetamines

备注

这种组合存在癫痫发作的显着风险。安非他明会增加呼吸频率，因此需要比正常剂量更高的镇静剂剂量。如果安非他明首先失效，娱乐性剂量的普瑞巴林可能会抑制个体并导致呼吸停止。这两种物质在娱乐剂量下都会导致心脏紧张，并可能导致进一步危险的心脏并发症。

查看原文

There is a significant risk of seizures from this combination. Amphetamines increase respiration rate allowing for a higher dose of sedatives than normal. If amphetamines wears off first, recreational dosages of pregabalin may overcome the individual and cause respiratory arrest. Both substances at recreational dosages cause strain of the heart and may lead to further dangerous heart complications.

来源

author: Martin, D., & Le, J. K. (2023)
标题: Amphetamine. In StatPearls. StatPearls Publishing.
链接: https://www.ncbi.nlm.nih.gov/books/NBK556103/

author: Altair. (n.d.-a)
标题: Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
链接: https://www.erowid.org/experiences/exp.php?ID=69917

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Ben-Menachem, E. (2004)
标题: Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Douke, R. (n.d.)
标题: Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
链接: https://www.erowid.org/experiences/exp.php?ID=83232

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N. A., & Livingston, J. H. (2006)
标题: Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Sean. (n.d.-b)
标题: Pregabalin - Erowid Exp - “Stay Away.”
链接: https://www.erowid.org/experiences/exp.php?ID=67302

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

风险等级

不安全（Unsafe）

caffeine

备注

这种组合存在癫痫发作的风险，尤其是在较高剂量时。较低剂量的咖啡因还会降低普瑞巴林的抗惊厥作用。咖啡因会增加呼吸频率，因此需要比正常剂量更高的镇静剂剂量。如果安非他明首先失效，娱乐性剂量的普瑞巴林可能会抑制个体并导致呼吸停止。这两种物质在娱乐剂量下都会导致心脏紧张，并可能导致进一步危险的心脏并发症。医疗剂量不太可能引起关注。

查看原文

There is a risk of seizures from this combination, especially at higher dosages. Caffeine additionally reduces pregabalin’s anticonvulsant effects found in lower dosages. Caffeine increases respiration rate allowing for a higher dose of sedatives than normal. If amphetamines wears off first, recreational dosages of pregabalin may overcome the individual and cause respiratory arrest. Both substances at recreational dosages cause strain of the heart and may lead to further dangerous heart complications. Medical dosages are unlikely to be of concern.

来源

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Ben‐Menachem, E. (2004)
标题: Pregabalin Pharmacology and Its Relevance to Clinical Practice. Epilepsia, 45(s6), 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Chwedorowicz, R., Łukawski, K., Raszewski, G., & Czuczwar, S. J. (2022)
标题: Effect of caffeine on the anticonvulsant action of pregabalin against electroconvulsions in mice. Pharmacological Reports: PR, 74(2), 431–437.
链接: https://doi.org/10.1007/s43440-022-00356-1

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N., & Livingston, J. (2006)
标题: Aggravation of epilepsy by anti‐epileptic drugs. Developmental Medicine & Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Sean. (n.d.-b)
标题: Pregabalin - Erowid Exp - “Stay Away.”
链接: https://www.erowid.org/experiences/exp.php?ID=67302

author: Altair. (n.d.-a)
标题: Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
链接: https://www.erowid.org/experiences/exp.php?ID=69917

author: Douke, R. (n.d.)
标题: Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
链接: https://www.erowid.org/experiences/exp.php?ID=83232

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Miziak, B., Błaszczyk, B., Chrościńska-Krawczyk, M., & Czuczwar, S. J. (2023)
标题: Caffeine and Its Interactions with Antiseizure Medications—Is There a Correlation between Preclinical and Clinical Data? International Journal of Molecular Sciences, 24(24), 17569.
链接: https://doi.org/10.3390/ijms242417569

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

风险等级

不安全（Unsafe）

cannabis

备注

这两种物质可能会增加彼此的副作用，例如镇静、降低血压和提高心率。

查看原文

Both substances may increase each other's side effects, such as sedation, lowered blood pressure, and raised heart rate.

来源

author: Balachandran, P., Elsohly, M., & Hill, K. P.
标题: Cannabidiol Interactions with Medications, Illicit Substances, and Alcohol: a Comprehensive Review (2021)
链接: https://doi.org/10.1007/s11606-020-06504-8

author: Klein, T. A., & Clark, C. S.
标题: Therapeutic use of cannabis in the US. The Nurse Practitioner, 47(12) (2022)
链接: https://doi.org/10.1097/01.NPR.0000884880.81603.c5

author: Lile, J. A., Alcorn, J. L., Hays, L. R., Kelly, T. H., Stoops, W. W., Wesley, M. J., & Westgate, P. M.
标题: Influence of Pregabalin Maintenance on Cannabis Effects and Related Behaviors in Daily Cannabis Users. Experimental and Clinical Psychopharmacology, 30(5) (2022)
链接: https://doi.org/10.1037/pha0000464

author: Vázquez, M., Guevara, N., Maldonado, C., Guido, P. C., & Schaiquevich, P.
标题: Potential Pharmacokinetic Drug‐Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain (2020)
链接: https://doi.org/10.1155/2020/3902740

风险等级

低风险 · 协同（Low Risk & Synergy）

cocaine

备注

这种组合存在癫痫发作的显着风险。兴奋剂会增加呼吸频率，从而允许使用比正常剂量更高的镇静剂。如果可卡因首先消失，娱乐性剂量的普瑞巴林可能会抑制个体并导致呼吸停止。这两种物质在娱乐剂量下都会使心脏紧张，并可能导致进一步危险的心脏并发症。当组合更高剂量时，该组合具有更大的高铁血红蛋白血症风险。

查看原文

There is a significant risk of seizures from this combination. Stimulants increase respiration rate, allowing for a higher dose of sedatives than normal. If cocaine wears off first, recreational dosages of pregabalin may overcome the individual and cause respiratory arrest. Both substances at recreational dosages strain the heart and may lead to further dangerous heart complications. The combination has a greater risk of methemoglobinemia when higher dosages are combined.

来源

author: Altair. (n.d.-a)
标题: Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure: Not Recreational.”
链接: https://www.erowid.org/experiences/exp.php?ID=69917

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Ben-Menachem, E. (2004)
标题: Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Douke, R. (n.d.)
标题: Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
链接: https://www.erowid.org/experiences/exp.php?ID=83232

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N. A., & Livingston, J. H. (2006)
标题: Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Hunter, L., Gordge, L., Dargan, P. I., & Wood, D. M. (2011)
标题: Methaemoglobinaemia associated with the use of cocaine and volatile nitrites as recreational drugs: a review. British Journal of Clinical Pharmacology, 72(1), 18–26.
链接: https://doi.org/10.1111/j.1365-2125.2011.03950.x

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Lappin, J. M., & Sara, G. E. (2019)
标题: Psychostimulant use and the brain. Addiction, 114(11), 2065–2077.
链接: https://doi.org/10.1111/add.14708

author: Ludlow, J. T., Wilkerson, R. G., & Nappe, T. M. (2025)
标题: Methemoglobinemia. In StatPearls. StatPearls Publishing.
链接: http://www.ncbi.nlm.nih.gov/books/NBK537317/

author: Pergolizzi, J. V., Magnusson, P., LeQuang, J. A. K., Breve, F., & Varrassi, G. (n.d.)
标题: Cocaine and Cardiotoxicity: A Literature Review. Cureus, 13(4), e14594.
链接: https://doi.org/10.7759/cureus.14594

author: Sean. (n.d.-b)
标题: Pregabalin - Erowid Exp - “Stay Away.”
链接: https://www.erowid.org/experiences/exp.php?ID=67302

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

风险等级

不安全（Unsafe）

dextromethorphan

备注

普瑞巴林和DXM可能会相互增强抑制、头晕、镇静等作用。如果剂量较高，可能会导致意外的意识丧失。两种药物都有癫痫发作的风险，联合使用会大大增加。

查看原文

Pregabalin and DXM may increase each other’s effects such as inhibition, dizziness, sedation. At higher doses this can lead to unexpected loss of consciousness. Both drugs have seizure concerns which is greatly increased in combination.

来源

author: Altair. (n.d.-a)
标题: Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
链接: https://www.erowid.org/experiences/exp.php?ID=69917

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Ben-Menachem, E. (2004)
标题: Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Douke, R. (n.d.)
标题: Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
链接: https://www.erowid.org/experiences/exp.php?ID=83232

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N. A., & Livingston, J. H. (2006)
标题: Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Journey, J. D., Agrawal, S., & Stern, E. (2025)
标题: Dextromethorphan Toxicity. In StatPearls. StatPearls Publishing.
链接: http://www.ncbi.nlm.nih.gov/books/NBK538502/

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Oh, S., Agrawal, S., Sabir, S., & Taylor, A. (2025)
标题: Dextromethorphan. In StatPearls. StatPearls Publishing.
链接: http://www.ncbi.nlm.nih.gov/books/NBK538216/

author: Sean. (n.d.-b)
标题: Pregabalin - Erowid Exp - “Stay Away.”
链接: https://www.erowid.org/experiences/exp.php?ID=67302

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

风险等级

不安全（Unsafe）

diphenhydramine

备注

这种组合存在癫痫发作的显着风险。这种组合很可能会增加彼此的负面副作用，例如恶心、头晕和失去意识。在较高剂量下，普瑞巴林可能会增加苯海拉明的谵妄作用、抑制作用和受伤风险。据报道，医疗剂量不是一个问题。

查看原文

There is a significant risk of seizures from this combination. The combination is likely to increase each other’s negative side effects, such as nausea, dizziness, and loss of consciousness. At higher dosages, pregabalin is likely to increase diphenhydramine’s deliriant effects, inhibition, and risk of injury. Medical dosages are not reported to be a concern.

来源

author: Altair. (n.d.-a)
标题: Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
链接: https://www.erowid.org/experiences/exp.php?ID=69917

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Ben-Menachem, E. (2004)
标题: Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Medline Plus Medical Encyclopedia (2023)
标题: Diphenhydramine overdose
链接: https://medlineplus.gov/ency/article/002636.htm

author: Douke, R. (n.d.)
标题: Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
链接: https://www.erowid.org/experiences/exp.php?ID=83232

author: Fakhr, M. S., Motamed Chaboki, P., Ashayeri, H., Sahranavard, P., Mohammadipanah, S., & Zamanabadi, M. N. (2023)
标题: Comparison of the effects of pregabalin and famotidine with pregabalin and diphenhydramine on postoperative abdominal pain. International Journal of Surgery Open, 58, 100674.
链接: https://doi.org/10.1016/j.ijso.2023.100674

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N. A., & Livingston, J. H. (2006)
标题: Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Jang, D. H., Manini, A. F., Trueger, N. S., Duque, D., Nestor, N. B., Nelson, L. S., & Hoffman, R. S. (2010)
标题: Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose. Clinical Toxicology, 48(9), 945–948.
链接: https://doi.org/10.3109/15563650.2010.527850

author: Kim, H., Kim, S. H., & Kim, J. B. (2021)
标题: Antihistamines as a common cause of new-onset seizures: a single-center observational study. Neurological Sciences: Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 42(6), 2505–2508.
链接: https://doi.org/10.1007/s10072-021-05043-2

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Schifano, F., Chiappini, S., Miuli, A., Mosca, A., Santovito, M. C., Corkery, J. M., Guirguis, A., Pettorruso, M., Di Giannantonio, M., & Martinotti, G. (2021)
标题: Focus on Over-the-Counter Drugs’ Misuse: A Systematic Review on Antihistamines, Cough Medicines, and Decongestants. Frontiers in Psychiatry, 12, 657397.
链接: https://doi.org/10.3389/fpsyt.2021.657397

author: Sean. (n.d.-b)
标题: Pregabalin - Erowid Exp - “Stay Away.”
链接: https://www.erowid.org/experiences/exp.php?ID=67302

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

author: Wolfson, A. R., Wong, D., Abrams, E. M., Waserman, S., & Sussman, G. L. (2022)
标题: Diphenhydramine: Time to Move on? The Journal of Allergy and Clinical Immunology: In Practice, 10(12), 3124–3130.
链接: https://doi.org/10.1016/j.jaip.2022.07.018

风险等级

不安全（Unsafe）

dmt

备注

普瑞巴林可以减轻 DMT 的焦虑和其他可能的副作用。此外，这种组合可能会增加抑制、头晕和受伤的风险。

查看原文

Pregabalin may reduce the anxiety and other possible side effects of DMT. Additionally, the combination may increase inhibition, dizziness, and risk of injury.

来源

author: Carbonaro, T. M., & Gatch, M. B. (2016)
标题: Neuropharmacology of N,N-Dimethyltryptamine. Brain Research Bulletin, 126(Pt 1), 74–88.
链接: https://doi.org/10.1016/j.brainresbull.2016.04.016

author: Cross, A. L., Viswanath, O., & Sherman, A. L. (2025)
标题: Pregabalin. In StatPearls. StatPearls Publishing.
链接: http://www.ncbi.nlm.nih.gov/books/NBK470341/

风险等级

低风险 · 协同（Low Risk & Synergy）

dox

备注

由于 DOx 药物的刺激作用和高剂量普瑞巴林的癫痫发作问题，应谨慎使用。普瑞巴林可以减少 DOx 药物的血管收缩、焦虑和其他副作用。此外，普瑞巴林可能会增加 DOx 药物的抑制作用和受伤风险。

查看原文

Caution should be given due to DOx drugs stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the vasoconstriction, anxiety, and other side effects of DOx drugs. Additionally, Pregabalin may increase DOx drugs inhibition and risk of injury.

来源

author: ScienceDirect Topics (n.d.)
标题: 2,5-Dimethoxy-4-iodoamphetamine - an overview
链接: https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/2-5-dimethoxy-4-iodoamphetamine

author: Altair. (n.d.-a)
标题: Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
链接: https://www.erowid.org/experiences/exp.php?ID=69917

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Barnett, R. Y., Baker, D. D., Kelly, N. E., McGuire, C. E., Fassette, T. C., & Gorniak, J. M. (2014)
标题: A Fatal Intoxication of 2,5-Dimethoxy-4-Chloroamphetamine: A Case Report. Journal of Analytical Toxicology, 38(8), 589–591.
链接: https://doi.org/10.1093/jat/bku087

author: Ben-Menachem, E. (2004)
标题: Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Burish, M. J., Thoren, K. L., Madou, M., Toossi, S., & Shah, M. (2015)
标题: Hallucinogens Causing Seizures? A Case Report of the Synthetic Amphetamine 2,5-Dimethoxy-4-Chloroamphetamine. The Neurohospitalist, 5(1), 32–34.
链接: https://doi.org/10.1177/1941874414528939

author: Douke, R. (n.d.)
标题: Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
链接: https://www.erowid.org/experiences/exp.php?ID=83232

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N. A., & Livingston, J. H. (2006)
标题: Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Jacob, P., & Shulgin, A. T. (1994)
标题: Structure-activity relationships of the classic hallucinogens and their analogs. NIDA Research Monograph, 146, 74–91.
链接: https://pubmed.ncbi.nlm.nih.gov/8742795/

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Luethi, D., Rudin, D., Hoener, M. C., & Liechti, M. E. (2022)
标题: Monoamine Receptor and Transporter Interaction Profiles of 4‐Alkyl‐Substituted 2,5‐Dimethoxyamphetamines. The FASEB Journal, 36(S1), fasebj.2022.36.S1.R2691.
链接: https://doi.org/10.1096/fasebj.2022.36.S1.R2691

author: Sean. (n.d.-b)
标题: Pregabalin - Erowid Exp - “Stay Away.”
链接: https://www.erowid.org/experiences/exp.php?ID=67302

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

author: Trout, K., & Daley, P. F. (2024)
标题: The origin of 2,5‐dimethoxy‐4‐methylamphetamine (DOM, STP). Drug Testing and Analysis, 16(12), 1496–1508.
链接: https://doi.org/10.1002/dta.3667

风险等级

谨慎（Caution）

ghb/gbl

备注

这两种物质会强烈且不可预测地相互增强，并可能迅速导致昏迷。它们都会增加彼此的副作用，如共济失调、镇静和中枢神经系统抑制。昏厥和记忆丧失的风险显着增加。如果使用者在醉酒状态下失去知觉，且不采取恢复姿势，则存在严重的呕吐物误吸风险。这种组合会增加癫痫发作的风险。

查看原文

The two substances potentiate each other strongly and unpredictably, and may rapidly lead to unconsciousness. They both increase each other's side effects such as ataxia, sedation, and CNS depression. Blackout and memory loss risk is significantly increased. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. There is an increased risk of seizures from this combination.

来源

author: Cagnin, A., Pompanin, S., Manfioli, V., Briani, C., Zambon, A., Saladini, M., & Dam, M. (2011)
标题: γ-Hydroxybutyric acid-induced psychosis and seizures.
链接: https://doi.org/10.1016/j.yebeh.2011.03.009

author: Castelli, M. P., Ferraro, L., Mocci, I., Carta, F., Carai, M. A. M., Antonelli, T., Tanganelli, S., Cignarella, G., & Gessa, G. L. (2003)
标题: Selective γ‐hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of γ‐hydroxybutyric acid.
链接: https://doi.org/10.1046/j.1471-4159.2003.02037.x

author: Eipe, N., & Penning, J. (2011)
标题: Postoperative Respiratory Depression Associated with Pregabalin: A Case Series and a Preoperative Decision Algorithm.
链接: https://doi.org/10.1155/2011/561604

author: Elliott, S. P., Burke, T., & Smith, C. (2017)
标题: Determining the Toxicological Significance of Pregabalin in Fatalities.
链接: https://doi.org/10.1111/1556-4029.13263

author: Evoy, K. E., Sadrameli, S., Contreras, J., Covvey, J. R., Peckham, A. M., & Morrison, M. D. (2021)
标题: Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update.
链接: https://doi.org/10.1007/s40265-020-01432-7

author: Galloway, G. P., Frederick, S. L., Staggers, F. E., Gonzales, M., Stalcup, S. A., & Smith, D. E. (1997)
标题: Gamma-hydroxybutyrate: an emerging drug of abuse that causes physical dependence.
链接: https://pubmed.ncbi.nlm.nih.gov/9060200/

author: Le, J. K., & Richards, J. R. (2025a)
标题: Gamma-Hydroxybutyrate Toxicity. In StatPearls.
链接: http://www.ncbi.nlm.nih.gov/books/NBK430781/

author: Le, J. K., & Richards, J. R. (2025b)
标题: Gamma-Hydroxybutyrate Toxicity. In StatPearls.
链接: http://www.ncbi.nlm.nih.gov/books/NBK430781/

author: Oskouei, Z., Moshiri, M., Raouf-Rahmati, A., Nemati, A., Bemani Naeini, M., Jomehpour, H., Roohbakhsh, A., Salmasi, Z., & Etemad, L. (2025)
标题: Seizures as an Adverse Effect of Pregabalin Consumption: A Systematic Review.
链接: https://doi.org/10.34172/ahj.1527

author: Venzi, M., Di Giovanni, G., & Crunelli, V. (2014)
标题: A Critical Evaluation of the Gamma‐Hydroxybutyrate (GHB) Model of Absence Seizures.
链接: https://doi.org/10.1111/cns.12337

author: Winters, W. D., & Spooner, C. E. (1965)
标题: Various seizure activities following gamma-hydroxybutyrate.
链接: https://doi.org/10.1016/0028-3908(65)90034-1

风险等级

危险（应避免）（Dangerous）

ketamine

备注

普瑞巴林和氯胺酮可能会产生协同作用，并增加彼此的负面副作用，例如恶心、头晕和意识丧失。由于癫痫发作的担忧，建议谨慎使用超出医疗剂量的药物，以及针对癫痫发作风险较高和/或行为较高的个人的医疗剂量。

查看原文

Pregabalin and ketamine may synergize and increase each other's negative side effects such as nausea, dizziness, and loss of consciousness. Caution is advised for beyond medical dosages due to seizure concerns, and medical dosages for individuals with higher risk seizure profiles and or behavior.

来源

author: Anwar, S., Cooper, J., Rahman, J., Sharma, C., & Langford, R. (2019)
标题: Prolonged Perioperative Use of Pregabalin and Ketamine to Prevent Persistent Pain after Cardiac Surgery. Anesthesiology, 131(1), 119–131.
链接: https://doi.org/10.1097/ALN.0000000000002751

author: Arendt-Nielsen, L., Mansikka, H., Staahl, C., Rees, H., Tan, K., Smart, T. S., Monhemius, R., Suzuki, R., & Drewes, A. M. (2011)
标题: A Translational Study of the Effects of Ketamine and Pregabalin on Temporal Summation of Experimental Pain. Regional Anesthesia & Pain Medicine, 36(6), 585–591.
链接: https://doi.org/10.1097/AAP.0b013e31822b0db0

author: Az, A., & Doğan, Y. (2024)
标题: Unexpected consequences: A case of ketamine‑induced seizure in procedural sedation. Turkish Journal of Emergency Medicine, 24(4), 259–261.
链接: https://doi.org/10.4103/tjem.tjem_67_24

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Ben‐Menachem, E. (2004)
标题: Pregabalin Pharmacology and Its Relevance to Clinical Practice. Epilepsia, 45(s6), 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N., & Livingston, J. (2006)
标题: Aggravation of epilepsy by anti‐epileptic drugs. Developmental Medicine & Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Kim, J. H., Lee, C. K., Yu, S. H., Min, B. D., Chung, C. E., & Kim, D. C. (2021)
标题: Ketamine-induced generalized convulsive seizure during procedural sedation. Archives of Craniofacial Surgery, 22(2), 119–121.
链接: https://doi.org/10.7181/acfs.2021.00094

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Martinez, V., Cymerman, A., Ben Ammar, S., Fiaud, J. F., Rapon, C., Poindessous, F., Judet, T., Chauvin, M., Bouhassira, D., Sessler, D., Mazoit, X., & Fletcher, D. (2014)
标题: The analgesic efficiency of combined pregabalin and ketamine for total hip arthroplasty: a randomised, double‐blind, controlled study. Anaesthesia, 69(1), 46–52.
链接: https://doi.org/10.1111/anae.12495

author: Shehata, I. M., Kohaf, N. A., ElSayed, M. W., Latifi, K., Aboutaleb, A. M., & Kaye, A. D. (2024)
标题: Ketamine: Pro or antiepileptic agent? A systematic review. Heliyon, 10(2), e24433.
链接: https://doi.org/10.1016/j.heliyon.2024.e24433

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

author: Zhou, Y., Sun, W., Fu, Y., Wang, J., Fan, J., Liang, Y., Jia, W., & Han, R. (2024)
标题: Effect of esketamine combined with pregabalin on acute postsurgical pain in patients who underwent resection of spinal neoplasms: a randomized controlled trial. Pain, 165(9), e96–e105.
链接: https://doi.org/10.1097/j.pain.0000000000003211

风险等级

谨慎（Caution）

lsd

备注

由于 LSD 的刺激作用和高剂量时普瑞巴林的癫痫发作问题，应小心谨慎。普瑞巴林可以减轻 LSD 的血管收缩、焦虑和其他副作用。此外，普瑞巴林可能会增加 LSD 的抑制作用和受伤风险。

查看原文

Caution should be given due to LSD’s stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the vasoconstriction, anxiety, and other side effects of LSD. Additionally, Pregabalin may increase LSD’s inhibition and risk of injury.

来源

author: Altair. (n.d.-a)
标题: Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
链接: https://www.erowid.org/experiences/exp.php?ID=69917

author: Baquiran, M., Keyes, D., & Al Khalili, Y. (2025)
标题: Lysergic Acid Diethylamide Toxicity. In StatPearls. StatPearls Publishing.
链接: http://www.ncbi.nlm.nih.gov/books/NBK553216/

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Ben-Menachem, E. (2004)
标题: Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Douke, R. (n.d.)
标题: Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
链接: https://www.erowid.org/experiences/exp.php?ID=83232

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N. A., & Livingston, J. H. (2006)
标题: Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Sean. (n.d.-b)
标题: Pregabalin - Erowid Exp - “Stay Away.”
链接: https://www.erowid.org/experiences/exp.php?ID=67302

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

author: Soto-Angona, Ó., Fortea, A., Fortea, L., Martínez-Ramírez, M., Santamarina, E., López, F. J. G., Knudsen, G. M., & Ona, G. (2024)
标题: Do classic psychedelics increase the risk of seizures? A scoping review. European Neuropsychopharmacology, 85, 35–42.
链接: https://doi.org/10.1016/j.euroneuro.2024.05.002

风险等级

谨慎（Caution）

mdma

备注

这种组合存在癫痫发作的显着风险。安非他明会增加呼吸频率，因此需要比正常剂量更高的镇静剂剂量。如果安非他明首先失效，娱乐性剂量的普瑞巴林可能会抑制个体并导致呼吸停止。这两种物质在娱乐剂量下都会导致心脏紧张，并可能导致进一步危险的心脏并发症。据报道，医疗剂量不是一个问题

查看原文

来源

author: Alo, C., & Kioka, M. J. (2024)
标题: Rave gone wrong: MDMA- induced medical emergency at electrical daisy carnival. A case report. Toxicology Reports, 13, 101739.
链接: https://doi.org/10.1016/j.toxrep.2024.101739

author: Altair. (n.d.-a)
标题: Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
链接: https://www.erowid.org/experiences/exp.php?ID=69917

author: Ben-Menachem, E. (2004)
标题: Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Christie, D., Yazar-Klosinski, B., Nosova, E., Kryskow, P., Siu, W., Lessor, D., & Argento, E. (2022)
标题: MDMA-assisted therapy is associated with a reduction in chronic pain among people with post-traumatic stress disorder. Frontiers in Psychiatry, 13.
链接: https://doi.org/10.3389/fpsyt.2022.939302

author: Douke, R. (n.d.)
标题: Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
链接: https://www.erowid.org/experiences/exp.php?ID=83232

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Oskouei, Z., Moshiri, M., Raouf-Rahmati, A., Nemati, A., Bemani Naeini, M., Jomehpour, H., Roohbakhsh, A., Salmasi, Z., & Etemad, L. (2025)
标题: Seizures as an Adverse Effect of Pregabalin Consumption: A Systematic Review. Addiction & Health, 17, 1527.
链接: https://doi.org/10.34172/ahj.1527

author: Rietjens, S. J., Sikma, M. A., Hunault, C. C., De Lange, D. W., & Hondebrink, L. (2022)
标题: Pregabalin poisoning: Evaluation of dose‐toxicity relationship. British Journal of Clinical Pharmacology, 88(3), 1288–1297.
链接: https://doi.org/10.1111/bcp.15073

author: Sean. (n.d.-b)
标题: Pregabalin - Erowid Exp - “Stay Away.”
链接: https://www.erowid.org/experiences/exp.php?ID=67302

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

author: Vollenweider, F. X., Gamma, A., Liechti, M., & Huber, T. (1998)
标题: Psychological and cardiovascular effects and short-term sequelae of MDMA (“ecstasy”) in MDMA-naïve healthy volunteers. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 19(4), 241–251.
链接: https://doi.org/10.1016/S0893-133X(98)00013-X

风险等级

不安全（Unsafe）

mephedrone

备注

这种组合存在癫痫发作的显着风险。甲氧麻黄酮会增加呼吸频率，从而允许比正常情况下使用更高剂量的镇静剂。如果甲氧麻黄酮首先失效，休闲剂量的普瑞巴林可能会抑制个体并导致呼吸停止。这两种物质在娱乐剂量下都会导致心脏紧张，并可能导致进一步危险的心脏并发症。

查看原文

There is a significant risk of seizures from this combination. Mephedrone increases respiration rate allowing for a higher dose of sedatives than normal. If mephedrone wears off first, recreational dosages of pregabalin may overcome the individual and cause respiratory arrest. Both substances at recreational dosages cause strain of the heart and may lead to further dangerous heart complications.

来源

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Ben‐Menachem, E. (2004)
标题: Pregabalin Pharmacology and Its Relevance to Clinical Practice. Epilepsia, 45(s6), 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Dargan, P. I., Sedefov, R., Gallegos, A., & Wood, D. M. (2011)
标题: The pharmacology and toxicology of the synthetic cathinone mephedrone (4‐methylmethcathinone). Drug Testing and Analysis, 3(7–8), 454–463.
链接: https://doi.org/10.1002/dta.312

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N., & Livingston, J. (2006)
标题: Aggravation of epilepsy by anti‐epileptic drugs. Developmental Medicine & Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Sean. (n.d.-b)
标题: Pregabalin - Erowid Exp - “Stay Away.”
链接: https://www.erowid.org/experiences/exp.php?ID=67302

author: Altair. (n.d)
标题: Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
链接: https://www.erowid.org/experiences/exp.php?ID=69917

author: Douke, R. (n.d.)
标题: Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
链接: https://www.erowid.org/experiences/exp.php?ID=83232

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Kehr, J., Ichinose, F., Yoshitake, S., Goiny, M., Sievertsson, T., Nyberg, F., & Yoshitake, T. (2011)
标题: Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats: Mephedrone increases both DA and 5-HT in rat brain. British Journal of Pharmacology, 164(8), 1949–1958.
链接: https://doi.org/10.1111/j.1476-5381.2011.01499.x

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Meng, H., Cao, J., Kang, J., Ying, X., Ji, J., Reynolds, W., & Rampe, D. (2012)
标题: Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat. Toxicology Letters, 208(1), 62–68.
链接: https://doi.org/10.1016/j.toxlet.2011.10.010

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

风险等级

不安全（Unsafe）

mescaline

备注

由于麦斯卡林的刺激作用和普瑞巴林在较高剂量下可能引起癫痫发作，因此应谨慎使用。普瑞巴林可以减少麦司卡林的血管收缩、焦虑和其他副作用。此外，普瑞巴林可能会增加麦司卡林的抑制作用和受伤风险。

查看原文

Caution should be given due to mescaline’s stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the vasoconstriction, anxiety, and other side effects of mescaline. Additionally, Pregabalin may increase mescaline’s inhibition and risk of injury.

来源

author: Altair. (n.d.-a)
标题: Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
链接: https://www.erowid.org/experiences/exp.php?ID=69917

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Ben-Menachem, E. (2004)
标题: Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Douke, R. (n.d.)
标题: Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
链接: https://www.erowid.org/experiences/exp.php?ID=83232

author: Freidel, N., Kreuder, L., Rabinovitch, B. S., Chen, F. Y., Huang, R. S. T., & Lewis, E. C. (2024)
标题: Psychedelics, epilepsy, and seizures: a review. Frontiers in Pharmacology, 14.
链接: https://doi.org/10.3389/fphar.2023.1326815

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N. A., & Livingston, J. H. (2006)
标题: Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Sean. (n.d.-b)
标题: Pregabalin - Erowid Exp - “Stay Away.”
链接: https://www.erowid.org/experiences/exp.php?ID=67302

author: Simonsson, O., Goldberg, S. B., Chambers, R., Osika, W., Long, D. M., & Hendricks, P. S. (2022)
标题: Prevalence and associations of classic psychedelic-related seizures in a population-based sample. Drug and Alcohol Dependence, 239, 109586.
链接: https://doi.org/10.1016/j.drugalcdep.2022.109586

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

author: Soto-Angona, Ó., Fortea, A., Fortea, L., Martínez-Ramírez, M., Santamarina, E., López, F. J. G., Knudsen, G. M., & Ona, G. (2024)
标题: Do classic psychedelics increase the risk of seizures? A scoping review. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 85, 35–42.
链接: https://doi.org/10.1016/j.euroneuro.2024.05.002

风险等级

谨慎（Caution）

mushrooms

备注

普瑞巴林可以减轻焦虑和裸盖菇素蘑菇的其他可能的副作用。此外，这种组合可能会增加抑制、头晕和受伤的风险。

查看原文

Pregabalin may reduce the anxiety and other possible side effects of Psilocybin Mushrooms. Additionally, the combination may increase inhibition, dizziness, and risk of injury.

来源

author: Cross, A. L., Viswanath, O., & Sherman, A. L. (2025)
标题: Pregabalin. In StatPearls. StatPearls Publishing.
链接: http://www.ncbi.nlm.nih.gov/books/NBK470341/

author: ScienceDirect Topics. (n.d.)
标题: Psilocybin - an overview
链接: https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/psilocybin

风险等级

低风险 · 协同（Low Risk & Synergy）

mxe

备注

普瑞巴林和 MXE 可能会协同作用并增加彼此的负面副作用，例如恶心、头晕和意识丧失。由于癫痫发作的担忧，建议谨慎使用任何高于低剂量的剂量，以及针对癫痫发作风险较高和/或行为的个体的所有剂量。

查看原文

Pregabalin and MXE may synergize and increase each other’s negative side effects such as nausea, dizziness, and loss of consciousness. Caution is advised for anything above low dosages due to seizure concerns, and all dosages for individuals with higher risk seizure profiles and or behavior.

来源

author: Anwar, S., Cooper, J., Rahman, J., Sharma, C., & Langford, R. (2019)
标题: Prolonged Perioperative Use of Pregabalin and Ketamine to Prevent Persistent Pain after Cardiac Surgery. Anesthesiology, 131(1), 119–131.
链接: https://doi.org/10.1097/ALN.0000000000002751

author: Arendt-Nielsen, L., Mansikka, H., Staahl, C., Rees, H., Tan, K., Smart, T. S., Monhemius, R., Suzuki, R., & Drewes, A. M. (2011)
标题: A Translational Study of the Effects of Ketamine and Pregabalin on Temporal Summation of Experimental Pain: Regional Anesthesia and Pain Medicine, 36(6), 585–591.
链接: https://doi.org/10.1097/AAP.0b013e31822b0db0

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Ben‐Menachem, E. (2004)
标题: Pregabalin Pharmacology and Its Relevance to Clinical Practice. Epilepsia, 45(s6), 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N., & Livingston, J. (2006)
标题: Aggravation of epilepsy by anti‐epileptic drugs. Developmental Medicine & Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–552.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Marti, M., Talani, G., Miliano, C., Bilel, S., Biggio, F., Bratzu, J., Diana, M., De Luca, M. A., & Fattore, L. (2021)
标题: New insights into methoxetamine mechanisms of action: Focus on serotonergic 5-HT2 receptors in pharmacological and behavioral effects in the rat. Experimental Neurology, 345, 113836.
链接: https://doi.org/10.1016/j.expneurol.2021.113836

author: Martinez, V., Cymerman, A., Ben Ammar, S., Fiaud, J. F., Rapon, C., Poindessous, F., Judet, T., Chauvin, M., Bouhassira, D., Sessler, D., Mazoit, X., & Fletcher, D. (2014)
标题: The analgesic efficiency of combined pregabalin and ketamine for total hip arthroplasty: a randomised, double‐blind, controlled study. Anaesthesia, 69(1), 46–52.
链接: https://doi.org/10.1111/anae.12495

author: Roth, B. L., Gibbons, S., Arunotayanun, W., Huang, X.-P., Setola, V., Treble, R., & Iversen, L. (2013)
标题: The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor. PLoS ONE, 8(3), e59334.
链接: https://doi.org/10.1371/journal.pone.0059334

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

author: Zhou, Y., Sun, W., Fu, Y., Wang, J., Fan, J., Liang, Y., Jia, W., & Han, R. (2024)
标题: Effect of esketamine combined with pregabalin on acute postsurgical pain in patients who underwent resection of spinal neoplasms: a randomized controlled trial. Pain, 165(9), e96–e105.
链接: https://doi.org/10.1097/j.pain.0000000000003211

风险等级

谨慎（Caution）

nbomes

备注

据报道，NBOMes 和普瑞巴林有显着的癫痫发作风险，联合使用可能会增加这种风险。普瑞巴林的治疗剂量不太可能引起关注，并且可能会减少 NBOMes 的副作用，例如血管收缩和焦虑。

查看原文

NBOMes and pregabalin are reported to have significant seizure concerns that are likely to increase in combination. Therapeutic dosages of pregabalin are unlikely to be of concern and may decrease NBOMes side effects such as vasoconstriction and anxiety.

来源

author: Altair. (n.d.-a)
标题: Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
链接: https://www.erowid.org/experiences/exp.php?ID=69917

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Ben-Menachem, E. (2004)
标题: Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Douke, R. (n.d.)
标题: Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
链接: https://www.erowid.org/experiences/exp.php?ID=83232

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N. A., & Livingston, J. H. (2006)
标题: Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Kyriakou, C., Marinelli, E., Frati, P., Santurro, A., Afxentiou, M., Zaami, S., & Busardo, F. P. (2015)
标题: NBOMe: new potent hallucinogens--pharmacology, analytical methods, toxicities, fatalities: a review. European Review for Medical and Pharmacological Sciences, 19(17), 3270–3281.
链接: https://pubmed.ncbi.nlm.nih.gov/26400534/

author: Sean. (n.d.-b)
标题: Pregabalin - Erowid Exp - “Stay Away.”
链接: https://www.erowid.org/experiences/exp.php?ID=67302

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

author: Zawilska, J. B., Kacela, M., & Adamowicz, P. (2020)
标题: NBOMes–Highly Potent and Toxic Alternatives of LSD. Frontiers in Neuroscience, 14, 78.
链接: https://doi.org/10.3389/fnins.2020.00078

风险等级

危险（应避免）（Dangerous）

nitrous

备注

这两种物质都会增强另一种物质引起的共济失调和镇静作用，并且在较高剂量时可能会增加意识丧失的风险。在失去知觉时，如果不处于恢复姿势，则有呕吐物误吸的风险。该组合可能会增加抑制作用和受伤风险。此外，在普瑞巴林的影响下滥用亚硝酸可能会增加癫痫发作的风险。医疗剂量不太可能成为问题。

查看原文

Both substances potentiate the ataxia and sedation caused by the other, and may increase the risk of loss of consciousness at higher dosages. While unconscious, vomit aspiration is a risk if not placed in the recovery position. The combination may increase inhibition and risk of injury. Additionally, abuse of nitrous while under the influence of pregabalin may increase the risk of seizures. Medical dosages are unlikely to be a concern.

来源

author: Barker-Haliski, M., & White, H. S. (2015)
标题: Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接: https://doi.org/10.1101/cshperspect.a022863

author: Ben‐Menachem, E. (2004)
标题: Pregabalin Pharmacology and Its Relevance to Clinical Practice. Epilepsia, 45(s6), 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Cross, A. L., Viswanath, O., & Sherman, A. L. (2025)
标题: Pregabalin. In StatPearls. StatPearls Publishing.
链接: http://www.ncbi.nlm.nih.gov/books/NBK470341/

author: Davidson, L. T. (2023)
标题: Recreational use of nitrous oxide causes seizure, pneumothorax, pneumomediastinum, and pneumopericardium: nitrous oxide and its harm, a case report. Upsala Journal of Medical Sciences, 128, 10.48101/ujms.v128.10281.
链接: https://doi.org/10.48101/ujms.v128.10281

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Gayatri, N., & Livingston, J. (2006)
标题: Aggravation of epilepsy by anti‐epileptic drugs. Developmental Medicine & Child Neurology, 48(5), 394–398.
链接: https://doi.org/10.1017/S0012162206000843

author: Hitchings, A. W. (2016)
标题: Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接: https://doi.org/10.1097/FAD.0000000000000016

author: Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题: Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接: https://doi.org/10.1111/bcp.14348

author: Knuf, K., & Maani, C. V. (2025)
标题: Nitrous Oxide. In StatPearls. StatPearls Publishing.
链接: http://www.ncbi.nlm.nih.gov/books/NBK532922/

author: Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接: https://doi.org/10.1111/j.1471-4159.2010.06625.x

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

author: Wagner, S., Clark, M., Wesche, D., Doedens, D., & Lloyd, A. (1992)
标题: Asphyxial Deaths from the Recreational Use of Nitrous Oxide. Journal of Forensic Sciences, 37(4), 1008–1015.
链接: https://doi.org/10.1520/JFS13286J

风险等级

谨慎（Caution）

opioids

来源

author: Eckhardt, K., Ammon, S., Hofmann, U., Riebe, A., Gugeler, N., & Mikus, G. (2000)
标题: Gabapentin enhances the analgesic effect of morphine in healthy volunteers. Anesthesia and Analgesia, 91(1), 185–191.
链接: https://doi.org/10.1097/00000539-200007000-00035

author: Eipe, N., & Penning, J. (2011)
标题: Postoperative respiratory depression associated with pregabalin: A case series and a preoperative decision algorithm. Pain Research & Management: The Journal of the Canadian Pain Society, 16(5), 353–356.
链接: https://doi.org/10.1155/2011/561604

author: Elliott, S. P., Burke, T., & Smith, C. (2017)
标题: Determining the Toxicological Significance of Pregabalin in Fatalities. Journal of Forensic Sciences, 62(1), 169–173.
链接: https://doi.org/10.1111/1556-4029.13263

author: Evoy, K. E., Sadrameli, S., Contreras, J., Covvey, J. R., Peckham, A. M., & Morrison, M. D. (2021)
标题: Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update. Drugs, 81(1), 125–156.
链接: https://doi.org/10.1007/s40265-020-01432-7

author: Gomes, T., Juurlink, D. N., Antoniou, T., Mamdani, M. M., Paterson, J. M., & Brink, W. van den. (2017)
标题: Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study. PLOS Medicine, 14(10), e1002396.
链接: https://doi.org/10.1371/journal.pmed.1002396

author: Lyndon, A., Audrey, S., Wells, C., Burnell, E. S., Ingle, S., Hill, R., Hickman, M., & Henderson, G. (2017)
标题: Risk to heroin users of polydrug use of pregabalin or gabapentin: Risks in combining gabapentoids with heroin. Addiction, 112(9), 1580–1589.
链接: https://doi.org/10.1111/add.13843

author: Peckham, A. M., Evoy, K. E., Covvey, J. R., Ochs, L., Fairman, K. A., & Sclar, D. A. (2018)
标题: Predictors of Gabapentin Overuse With or Without Concomitant Opioids in a Commercially Insured U.S. Population. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 38(4), 436–443.
链接: https://doi.org/10.1002/phar.2096

author: Research, C. for D. E. and. (2020)
标题: FDA warns about serious breathing problems with seizure and nerve pain medicines gabapentin (Neurontin, Gralise, Horizant) and pregabalin (Lyrica, Lyrica CR). FDA.
链接: https://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-about-serious-breathing-problems-seizure-and-nerve-pain-medicines-gabapentin-neurontin

风险等级

危险（应避免）（Dangerous）

tramadol

备注

癫痫发作的风险很大。这两种物质都是中枢神经系统抑制剂，彼此之间会产生不可预测的强烈增强作用，增加记忆丧失、严重共济失调和意识丧失的可能性。这种相互作用会造成更大的抑制和受伤的风险。如果用户失去知觉，强烈建议将其置于恢复位置并监测呼吸。据报道，医疗剂量不是一个问题。

查看原文

There is a significant risk of seizures. Both substances are CNS depressants, potentiating each other strongly and unpredictably, raising the chances of memory loss, severe ataxia, and unconsciousness. The interaction will cause greater inhibition and risk of injury. If the user falls unconscious it is strongly recommended to put them into the recovery position and monitor breathing. Medical dosages are not reported to be a concern.

来源

author: Altair. (n.d.-a)
标题: Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
链接: https://www.erowid.org/experiences/exp.php?ID=69917

author: Ben-Menachem, E. (2004)
标题: Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
链接: https://doi.org/10.1111/j.0013-9580.2004.455003.x

author: Boostani, R., & Derakhshan, S. (2012)
标题: Tramadol induced seizure: A 3-year study. Caspian Journal of Internal Medicine, 3(3), 484–487.
链接: https://pubmed.ncbi.nlm.nih.gov/24009919/

author: Douke, R. (n.d.)
标题: Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
链接: https://www.erowid.org/experiences/exp.php?ID=83232

author: French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题: Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.
链接: https://doi.org/10.1212/WNL.0000000000000119

author: Hassamal, S., Miotto, K., Dale, W., & Danovitch, I. (2018)
标题: Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures. The American Journal of Medicine, 131(11), 1382.e1-1382.e6.
链接: https://doi.org/10.1016/j.amjmed.2018.04.025

author: Lyndon, A., Audrey, S., Wells, C., Burnell, E. S., Ingle, S., Hill, R., Hickman, M., & Henderson, G. (2017)
标题: Risk to heroin users of polydrug use of pregabalin or gabapentin: Risks in combining gabapentoids with heroin. Addiction, 112(9), 1580–1589.
链接: https://doi.org/10.1111/add.13843

author: Rietjens, S. J., Sikma, M. A., Hunault, C. C., De Lange, D. W., & Hondebrink, L. (2022)
标题: Pregabalin poisoning: Evaluation of dose‐toxicity relationship. British Journal of Clinical Pharmacology, 88(3), 1288–1297.
链接: https://doi.org/10.1111/bcp.15073

author: Sean. (n.d.-b)
标题: Pregabalin - Erowid Exp - “Stay Away.”
链接: https://www.erowid.org/experiences/exp.php?ID=67302

author: Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题: Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接: https://doi.org/10.1080/24734306.2018.1458465

风险等级

不安全（Unsafe）

后遗时间

1-12 小时

剂量

口服

常规: 300-600mg
轻度: 150-300mg
强效: 600-900mg

持续时间

6-14 小时

效应

Anxiolytic 镇静剂 Muscle Relaxant Amnesia Dystaxia 催眠药

起效时间

90-150 分钟

名称

pregabalin

通用名

Pregabalin

属性

后遗效应: 1–12 小时.
别名: lyrica pregablin
分类: 抑制剂习惯形成常规
剂量: Light: 150-300mg Common: 300-600mg Strong: 600-900mg
持续: 6–14 小时 (dependant on dose)
效应: Anxiolytic, Sedative, Muscle Relaxant, Amnesia, Dystaxia, Hypnotic.
起效: 90–150 分钟.
摘要: Pregabalin (Lyrica) is a GABA derivative that is used to treat neuropathic pain, seizures, and anxiety. Pregabalin independently has seizure concerns at higher dosages and concerns at lower dosages with preexisting risk factors and conditions.

效应

Acuity enhancement: https://psychonautwiki.org/wiki/Acuity_enhancement
Amnesia: https://psychonautwiki.org/wiki/Amnesia
Anxiety suppression: https://psychonautwiki.org/wiki/Anxiety_suppression
Auditory enhancement: https://psychonautwiki.org/wiki/Auditory_enhancement
Cognitive euphoria: https://psychonautwiki.org/wiki/Cognitive_euphoria
Colour enhancement: https://psychonautwiki.org/wiki/Colour_enhancement
Disinhibition: https://psychonautwiki.org/wiki/Disinhibition
Dizziness: https://psychonautwiki.org/wiki/Dizziness
Empathy, love, and sociability enhancement: https://psychonautwiki.org/wiki/Empathy,_love,_and_sociability_enhancement
Information processing suppression: https://psychonautwiki.org/wiki/Information_processing_suppression
Internal hallucinations: https://psychonautwiki.org/wiki/Internal_hallucinations
Motivation enhancement: https://psychonautwiki.org/wiki/Motivation_enhancement
Motor control loss: https://psychonautwiki.org/wiki/Motor_control_loss
Muscle spasms: https://psychonautwiki.org/wiki/Muscle_spasms
Pain relief: https://psychonautwiki.org/wiki/Pain_relief
Respiratory depression: https://psychonautwiki.org/wiki/Respiratory_depression
Sedation: https://psychonautwiki.org/wiki/Sedation
Seizure suppression: https://psychonautwiki.org/wiki/Seizure_suppression
Thought deceleration: https://psychonautwiki.org/wiki/Thought_deceleration

来源

general: Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat - http://www.ncbi.nlm.nih.gov/pubmed/22734646

来源与许可

TripSit · 药物资料

TripSit 数据规则：仅限非商业使用，需署名并在每个展示页附来源链接；组合数据仅为快速参考，需结合个体研究判断。

Reference snapshot, not a forum post. Source: TripSit. Noncommercial reuse with TripSit attribution and a source link on every display page; combination data is a quick reference requiring further individual research. https://wiki.tripsit.me/wiki/Factsheets ; https://wiki.tripsit.me/wiki/Drug_combinations . The package.json ISC software tag does not replace these data-specific terms. Raw source: https://raw.githubusercontent.com/TripSit/drugs/83670cb6bc8863615fcb9be081c87f061b42dea4/drugs.json Fetched at: 2026-10-23T07:01:06.728397+00:00 Record key: drug:pregabalin

来源主页：https://wiki.tripsit.me/wiki/Factsheets
组合说明：https://wiki.tripsit.me/wiki/Drug_combinations