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TripSit · lithium + ketamine

TripSit 参考资料 · 相互作用 2026-10-23

本条目为第三方公开资料的归档,仅用于学术研究与科普,不构成任何操作指导或医学建议;物质处理涉及法律与健康风险,请在专业、合法的条件下自行核验。

正文中文为机器翻译,仅供参考;专业内容以折叠的原文为准。

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锂可以增强和延长氯胺酮的抗抑郁作用。

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Lithium may enhance and prolong the antidepressant effects of ketamine.

来源
author
Costi, S., Soleimani, L., Glasgow, A., Brallier, J., Spivack, J., Schwartz, J., Levitch, C. F., Richards, S., Hoch, M., Stade, E. C., Welch, A., Collins, K. A., Feder, A., Iosifescu, D. V., Charney, D. S., & Murrough, J. W. (2019)
标题
Lithium continuation therapy following ketamine in patients with treatment resistant unipolar depression: a randomized controlled trial. Neuropsychopharmacology, 44(10), 1812–1819.
链接
https://doi.org/10.1038/s41386-019-0365-0
author
Diazgranados, N., Ibrahim, L., Brutsche, N. E., Newberg, A., Kronstein, P., Khalife, S., Kammerer, W. A., Quezado, Z., Luckenbaugh, D. A., Salvadore, G., Machado-Vieira, R., Manji, H. K., & Zarate, C. A. (2010)
标题
A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression. Archives of General Psychiatry, 67(8), 793.
链接
https://doi.org/10.1001/archgenpsychiatry.2010.90
author
Price, J. B., Yates, C. G., Morath, B. A., Van De Wakker, S. K., Yates, N. J., Butters, K., Frye, M. A., McGee, S. L., & Tye, S. J. (2021)
标题
Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression. Translational Psychiatry, 11(1), 1–12.
链接
https://doi.org/10.1038/s41398-021-01716-w
author
Scheuing, L., Chiu, C.-T., Liao, H.-M., & Chuang, D.-M. (2015)
标题
Antidepressant mechanism of ketamine: perspective from preclinical studies. Frontiers in Neuroscience, 9.
链接
https://doi.org/10.3389/fnins.2015.00249
author
Toulany, J., Cunningham, J. E. A., & Nunes, A. (2025)
标题
Overlap and Divergence in Ketamine and Lithium Response in Bipolar Disorder: A Scoping Review. Pharmaceuticals, 18(11), 1662.
链接
https://doi.org/10.3390/ph18111662
author
Wilkowska, A., Szałach, Ł., & Cubała, W. J. (2020)
标题
Ketamine in Bipolar Disorder: A Review. Neuropsychiatric Disease and Treatment, 16, 2707–2717.
链接
https://doi.org/10.2147/NDT.S282208
风险等级
Low Risk & No Synergy
物质 A
锂盐
物质 B
氯胺酮
来源与许可

TripSit · 药物资料

TripSit 数据规则:仅限非商业使用,需署名并在每个展示页附来源链接;组合数据仅为快速参考,需结合个体研究判断。

Reference snapshot, not a forum post. Source: TripSit. Noncommercial reuse with TripSit attribution and a source link on every display page; combination data is a quick reference requiring further individual research. https://wiki.tripsit.me/wiki/Factsheets ; https://wiki.tripsit.me/wiki/Drug_combinations . The package.json ISC software tag does not replace these data-specific terms. Raw source: https://raw.githubusercontent.com/TripSit/drugs/83670cb6bc8863615fcb9be081c87f061b42dea4/combos.json Fetched at: 2026-10-23T07:01:06.728397+00:00 Record key: combination:["lithium","ketamine"]

来源主页:https://wiki.tripsit.me/wiki/Factsheets
组合说明:https://wiki.tripsit.me/wiki/Drug_combinations