本条目为第三方公开资料的归档，仅用于学术研究与科普，不构成任何操作指导或医学建议；物质处理涉及法律与健康风险，请在专业、合法的条件下自行核验。
正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。
- 详情
- 别名
- etoh beer 酒精 booze hooch
- 分类
- 抑制剂 习惯形成 常规
- 相互作用
- 2c-t-x
- 备注
这两类化合物都可能发生不可预测的相互作用。应谨慎行事。
查看原文
Both these classes of compound can interact unpredictably. Caution should be exercised.
- 风险等级
- Low Risk & Decrease
- 2c-x
- 风险等级
- Low Risk & Decrease
- 5-meo-xxt
- 风险等级
- Low Risk & Decrease
- amphetamines
- 备注
喝兴奋剂是有风险的，因为酒精的镇静作用会降低，而这些正是身体用来衡量醉酒程度的指标。这通常会导致饮酒过量，抑制作用大大降低，肝损伤的风险很高，脱水也会增加。它们还会让您喝到超过正常情况下可能会昏倒的程度，从而增加了风险。如果您决定这样做，那么您应该设定每小时饮酒量的限制并坚持下去，记住您会感觉酒精和兴奋剂更少。缓释制剂可能会严重妨碍睡眠，进一步加剧宿醉。
查看原文
Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol and the stimulant less. Extended release formulations may severely impede sleep, further worsening the hangover.
- 风险等级
- 谨慎 （Caution）
- amt
- 备注
aMT 在大脑中具有广泛的作用机制，酒精也是如此，因此组合可能是不可预测的
查看原文
aMT has a broad mechanism of action in the brain and so does alcohol so the combination can be unpredictable
- 风险等级
- 谨慎 （Caution）
- benzodiazepines
- 备注
摄入乙醇可能会增强许多苯二氮卓类药物的中枢神经系统作用。这两种物质会强烈且不可预测地相互增强，很快就会导致昏迷。在失去知觉时，如果不处于恢复姿势，则有呕吐物误吸的风险。昏厥和记忆丧失几乎是肯定的。
查看原文
Ethanol ingestion may potentiate the CNS effects of many benzodiazepines. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Blacking out and memory loss is almost certain.
- 风险等级
- 危险（应避免） （Dangerous）
- caffeine
- 风险等级
- Low Risk & No Synergy
- cannabis
- 备注
如果过量，这种组合会引起恶心。
查看原文
In excess, this combination can cause nausea.
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- cocaine
- 备注
可卡因可以减少酒精的一些醉人作用，导致一些人比平时喝酒更多，从而导致更大的行为和身体健康风险。关于可卡乙烯（一种酒精和可卡因混合产生的代谢物）也存在一些争议，一些研究人员认为它比可卡因本身的心脏毒性更大。混合这些物质时要适量。
查看原文
Cocaine can decrease some of the intoxicating effects of alcohol, causing some people to drink more than they otherwise would, which leads to greater behavioral and physical health risks. There is also some debate about cocaethylene, a metabolite produced when combining alcohol and cocaine, with some researchers positing that it is more cardiotoxic than cocaine on its own. Use moderation when combining these substances.
- 来源
- author
- McCance-Katz, E. F., Kosten, T. R., & Jatlow, P.
- 标题
- Concurrent use of cocaine and alcohol is more potent and potentially more toxic than use of either alone—A multiple-dose study.
- 链接
- https://doi.org/10.1016/S0006-3223(97)00426-5
- author
- Pergolizzi, J., Breve, F., Magnusson, P., LeQuang, J. A. K., & Varrassi, G.
- 标题
- Cocaethylene: When cocaine and alcohol are taken together. (2022)
- 链接
- https://doi.org/10.7759/cureus.22498
- author
- Shastry, S., Manoochehri, O., Richardson, L. D., & Manini, A. F.
- 标题
- Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose.
- 链接
- https://doi.org/10.1111/acem.14584
- author
- Wiener, S. E., Sutijono, D., Moon, C. H., Subramanian, R. A., Calaycay, J., Rushbrook, J. I., & Zehtabchi, S.
- 标题
- Patients with detectable cocaethylene are more likely to require intensive care unit admission after trauma.
- 链接
- https://doi.org/10.1016/j.ajem.2009.06.014
- 风险等级
- 不安全 （Unsafe）
- dextromethorphan
- 备注
这两种物质都会增强另一种物质引起的共济失调和镇静作用，高剂量时可能会导致意外的意识丧失。将受影响的人置于恢复位置，以防止吸入过量呕吐物。此外，中枢神经系统抑制会导致呼吸困难。避免在高于第一平台的任何地方。
查看原文
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place the affected individual in the recovery position to prevent vomit aspiration from excess. Additionally, CNS depression can lead to difficulty breathing. Avoid on anything higher than 1st plateau.
- 风险等级
- 危险（应避免） （Dangerous）
- diphenhydramine
- 备注
这两种物质会强烈且不可预测地相互增强，并可能迅速导致昏迷。它们都会增加彼此的副作用，如共济失调、镇静和中枢神经系统抑制。昏厥和记忆丧失显着增加。如果使用者在醉酒状态下失去知觉，且不采取恢复姿势，则存在严重的呕吐物误吸风险。酒精也可能会增加苯海拉明的谵妄作用。还应该注意的是，如果饮酒的人通常对酒精有脸红反应，苯海拉明可能会减少这种反应并掩盖酒精的一些影响。
查看原文
The two substances potentiate each other strongly and unpredictably, and may rapidly lead to unconsciousness. They both increase each other's side effects such as ataxia, sedation, and CNS depression. Blackouts and memory loss are significantly increased. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. Alcohol may also increase the deliriant effects of diphenhydramine. It should also be noted if the individual consuming alcohol typically has a flushing response to alcohol, diphenhydramine may reduce the reaction and mask some of the effects of the alcohol.
- 来源
- author
- ScienceDirect
- 标题
- Diphenhydramine - an overview (2024)
- 链接
- https://www.sciencedirect.com/topics/chemistry/diphenhydramine
- author
- ScienceDirect
- 标题
- Ethanol - an overview (2024)
- 链接
- https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/ethanol
- author
- Miller, N. S., Goodwin, D. W., Jones, F. C., Gabrielli, W. F., Pardo, M. P., Anand, M. M., & Hall, T. B.
- 标题
- Antihistamine blockade of alcohol-induced flushing in orientals. Journal of Studies on Alcohol, 49(1), 16-20 (1988)
- 链接
- https://doi.org/10.15288/jsa.1988.49.16
- author
- Sicari, V., & Zabbo, C. P.
- 标题
- Diphenhydramine. In StatPearls. StatPearls Publishing (2024)
- 链接
- http://www.ncbi.nlm.nih.gov/books/NBK526010/
- author
- Weathermon, R., & Crabb, D. W.
- 标题
- Alcohol and Medication Interactions. Alcohol Research & Health, 23(1), 40-54 (1999)
- 链接
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761694/
- 风险等级
- 危险（应避免） （Dangerous）
- dmt
- 风险等级
- Low Risk & Decrease
- dox
- 备注
喝兴奋剂是有风险的，因为酒精的镇静作用会降低，而这些正是身体用来衡量醉酒程度的指标。这通常会导致饮酒过量，抑制作用大大降低，肝损伤的风险很高，脱水也会增加。它们还会让您喝到超过正常情况下可能会昏倒的程度，从而增加了风险。
查看原文
Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk.
- 风险等级
- Low Risk & Decrease
- ghb/gbl
- 备注
即使剂量非常低，这种组合也会迅速导致记忆丧失、严重共济失调和意识丧失。失去知觉时吸入呕吐物的风险很高。
查看原文
Even in very low doses this combination rapidly leads to memory loss, severe ataxia and unconsciousness. There is a high risk of vomit aspiration while unconscious.
- 风险等级
- 危险（应避免） （Dangerous）
- ketamine
- 备注
这两种物质都会导致共济失调，并带来呕吐和昏迷的极高风险。如果使用者在醉酒状态下失去知觉，且不采取恢复姿势，则存在严重的呕吐物误吸风险。
查看原文
Both substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
- 风险等级
- 危险（应避免） （Dangerous）
- lsd
- 风险等级
- Low Risk & Decrease
- maois
- 备注
许多酒精饮料中的酪胺可能与单胺氧化酶抑制剂产生危险的反应，导致血压升高。
查看原文
Tyramine found in many alcoholic beverages can have dangerous reactions with MAOIs, causing an increase in blood pressure.
- 风险等级
- 不安全 （Unsafe）
- mdma
- 备注
MDMA 和酒精的结合可能会增加心血管系统的压力，并导致饮酒量增加。 MDMA 还可能损害人们识别醉酒程度的能力，导致饮酒量增加和决策失误。酒精与 MDMA 合用时，还可能增加脱水和体温过高（体温升高）的风险。
查看原文
The combination of MDMA and alcohol may increase strain on the cardiovascular system and lead to increased alcohol consumption. MDMA may also impair one's ability to recognize their level of drunkenness, leading to increased alcohol consumption and poor decision-making. Alcohol may also increase the risk of dehydration and hyperthermia (increased body temperature) when combined with MDMA.
- 来源
- author
- Hamida, S. B., Plute, E., Cosquer, B., Kelche, C., Jones, B. C., & Cassel, J.-C.
- 标题
- Interactions between ethanol and cocaine, amphetamine, or MDMA in the rat: thermoregulatory and locomotor effects. (2008)
- 链接
- https://doi.org/10.1007/s00213-007-1007-5
- author
- Ramaekers, J. G., & Kuypers, K. P. C.
- 标题
- Acute Effects of 3,4-Methylenedioxymethamphetamine (MDMA) on Behavioral Measures of Impulsivity: Alone and in Combination with Alcohol. (2006)
- 链接
- https://doi.org/10.1038/sj.npp.1300894
- author
- Hernández-López, C., Farré, M., Roset, P. N., Menoyo, E., Pizarro, N., Ortuño, J., Torrens, M., Camı́, J., & Torre, R. de la.
- 标题
- 3,4-Methylenedioxymethamphetamine (Ecstasy) and Alcohol Interactions in Humans: Psychomotor Performance, Subjective Effects, and Pharmacokinetics. (2002)
- 链接
- https://doi.org/10.1124/jpet.300.1.236
- author
- van Amsterdam, J., Brunt, T. M., Pierce, M., & van den Brink, W.
- 标题
- Hard Boiled: Alcohol Use as a Risk Factor for MDMA-Induced Hyperthermia: a Systematic Review. (2021)
- 链接
- https://doi.org/10.1007/s12640-021-00416-z
- 风险等级
- 谨慎 （Caution）
- mescaline
- 风险等级
- Low Risk & Decrease
- mushrooms
- 风险等级
- Low Risk & Decrease
- mxe
- 备注
这种组合存在记忆丧失、呕吐和严重共济失调的高风险。
查看原文
There is a high risk of memory loss, vomiting and severe ataxia from this combination.
- 风险等级
- 危险（应避免） （Dangerous）
- nbomes
- 风险等级
- Low Risk & Decrease
- nitrous
- 备注
这两种物质都会增强另一种物质引起的共济失调和镇静作用，高剂量时可能会导致意外的意识丧失。在失去知觉时，如果不处于恢复姿势，则有呕吐物误吸的风险。内存中断是有可能的。
查看原文
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
- 风险等级
- 谨慎 （Caution）
- opioids
- 备注
这两种物质都会增强另一种物质引起的共济失调和镇静作用，高剂量时可能会导致意外的意识丧失。将受影响的人置于恢复位置，以防止吸入过量呕吐物。内存中断很可能
查看原文
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place the affected individual in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely
- 风险等级
- 危险（应避免） （Dangerous）
- pcp
- 备注
这种组合的细节尚不清楚，但 PCP 通常以不可预测的方式相互作用。
查看原文
Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
- 风险等级
- 不安全 （Unsafe）
- ssris
- 备注
酒精可能会增强中枢神经系统活性药物的某些药理作用。联合使用可能会导致中枢神经系统进一步抑制和/或判断、思维和精神运动技能受损。
查看原文
Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
- 风险等级
- 谨慎 （Caution）
- tramadol
- 备注
重度中枢神经系统抑制剂，有癫痫发作的风险。这两种物质都会增强另一种物质引起的共济失调和镇静作用，高剂量时可能会导致意外的意识丧失。将受影响的人置于恢复位置，以防止吸入过量呕吐物。内存中断是有可能的。
查看原文
Heavy CNS depressants, risk of seizures. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place the affected individual in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely.
- 风险等级
- 危险（应避免） （Dangerous）
- 剂量说明
NOTE: Alcohol consumption should be spread out over a few hours and ideally separated by water breaks. Check the label on alcohol for unit content
- 后遗时间
- 6-48 小时
- 剂量
- 口服
- 常规
- 2-4units
- 重剂量
- 5-6units
- 轻度
- 1-2units
- 持续时间
- 1.5-3 小时
- 效应
- relaxation mood lift happiness sociability lowered inhibitions analgesia slurred speech flushed skin drowsiness tolerance euphoria amnesia
- 起效时间
- 15-30 分钟
- 相关链接
- 经验报告
- https://www.erowid.org/experiences/subs/exp_Alcohol.shtml
- 名称
- 酒精
- 通用名
- 酒精
- 属性
- 后遗效应
- 6–48 小时
- 别名
- etoh beer 酒精 booze hooch
- 分类
- 抑制剂 习惯形成 常规
- 检测窗口
- 12 hrs blood, 6-12 hrs saliva, 6-24 hrs urine
- 剂量
- Oral Light: 1-2units Common: 2-4units Heavy: 5-6units | NOTE: Alcohol consumption should be spread out over a few hours and ideally separated by water breaks. It is recommended to review the label on alcohol for unit content
- 持续
- 1.5–3 小时
- 效应
- relaxation, mood lift, happiness, sociability, lowered inhibitions, analgesia, slurred speech, flushed skin, drowsiness, tolerance, euphoria, amnesia
- 起效
- 15–30 分钟
- 摘要
Alcohol is a CNS depressant that acts through the GABAₐ receptor, and is one of the most common strong psychoactives used by humans. It has a long history of use and its intoxicating effects are well-studied and documented. It remains legal in most parts of the world.
- 效应
- Acuity suppression
- https://psychonautwiki.org/wiki/Acuity_suppression
- Amnesia
- https://psychonautwiki.org/wiki/Amnesia
- Analysis suppression
- https://psychonautwiki.org/wiki/Analysis_suppression
- Anxiety suppression
- https://psychonautwiki.org/wiki/Anxiety_suppression
- Auditory suppression
- https://psychonautwiki.org/wiki/Auditory_suppression
- Cognitive euphoria
- https://psychonautwiki.org/wiki/Cognitive_euphoria
- Compulsive redosing
- https://psychonautwiki.org/wiki/Compulsive_redosing
- Creativity suppression
- https://psychonautwiki.org/wiki/Creativity_suppression
- Dehydration
- https://psychonautwiki.org/wiki/Dehydration
- Delusions
- https://psychonautwiki.org/wiki/Delusions
- Depression
- https://psychonautwiki.org/wiki/Depression
- Difficulty urinating
- https://psychonautwiki.org/wiki/Difficulty_urinating
- Disinhibition
- https://psychonautwiki.org/wiki/Disinhibition
- Dizziness
- https://psychonautwiki.org/wiki/Dizziness
- Double vision
- https://psychonautwiki.org/wiki/Double_vision
- Ego inflation
- https://psychonautwiki.org/wiki/Ego_inflation
- Empathy, love, and sociability enhancement
- https://psychonautwiki.org/wiki/Empathy,_love,_and_sociability_enhancement
- Frequent urination
- https://psychonautwiki.org/wiki/Frequent_urination
- Headaches
- https://psychonautwiki.org/wiki/Headaches
- Increased blood pressure
- https://psychonautwiki.org/wiki/Increased_blood_pressure
- Information processing suppression
- https://psychonautwiki.org/wiki/Information_processing_suppression
- Language suppression
- https://psychonautwiki.org/wiki/Language_suppression
- Motor control loss
- https://psychonautwiki.org/wiki/Motor_control_loss
- Muscle relaxation
- https://psychonautwiki.org/wiki/Muscle_relaxation
- Nausea
- https://psychonautwiki.org/wiki/Nausea
- Pain relief
- https://psychonautwiki.org/wiki/Pain_relief
- Pattern recognition suppression
- https://psychonautwiki.org/wiki/Pattern_recognition_suppression
- Physical euphoria
- https://psychonautwiki.org/wiki/Physical_euphoria
- Respiratory depression
- https://psychonautwiki.org/wiki/Respiratory_depression
- Sedation
- https://psychonautwiki.org/wiki/Sedation
- Tactile suppression
- https://psychonautwiki.org/wiki/Tactile_suppression
- Temporary erectile dysfunction
- https://psychonautwiki.org/wiki/Temporary_erectile_dysfunction
- Thought deceleration
- https://psychonautwiki.org/wiki/Thought_deceleration
- Thought disorganization
- https://psychonautwiki.org/wiki/Thought_disorganization
- 来源
- general
- Alcohol and benzodiazepines in fatal poisonings. - https://www.ncbi.nlm.nih.gov/pubmed/12170103 Drinking while pregnant creates and strengthens many risks associated with childbirth. It will also increase the chances of premature labour, which can be incredibly dangerous for both the baby and mother. -
来源与许可
TripSit · 药物资料
TripSit 数据规则：仅限非商业使用，需署名并在每个展示页附来源链接；组合数据仅为快速参考，需结合个体研究判断。
来源主页：https://wiki.tripsit.me/wiki/Factsheets
组合说明：https://wiki.tripsit.me/wiki/Drug_combinations