TripSit · Dimethocaine

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

详情

别名

DMC CMD Larocaine

分类

兴奋剂 research-chemical 习惯形成 tentative

剂量说明

Note: Dimethocaine shows strong inter-individual variability due to NAT2 polymorphism. Redosing and high doses substantially increase cardiovascular and tissue toxicity risk.

剂量

鼻吸

常规

15-30mg

轻度

5-15mg

强效

30-50mg

效应

Stimulation Euphoria Increased alertness Local numbness Increased confidence Tachycardia (increased heart rate) Vasoconstriction Increased blood pressure Anxiety Jaw tension Insomnia

相关链接

经验报告

https://www.erowid.org/experiences/subs/exp_Dimethocaine.shtml

名称

dimethocaine

通用名

Dimethocaine

属性

后遗效应

Insufflated: 1–6 小时. | Note: After-effects commonly include fatigue, headache, nasal irritation, and residual cardiovascular strain.

别名

DMC CMD Larocaine

分类

兴奋剂 research-chemical 习惯形成 tentative

剂量

Insufflated Light: 5-15mg Common: 15-30mg Strong: 30-50mg. | Note: Local anesthesia can mask tissue damage; repeated dosing increases cardiotoxic risk.

持续

Insufflated: 1.5–3 小时. | NOTE: Duration varies significantly depending on metabolism, purity, and tolerance.

效应

Stimulation, Euphoria, Increased alertness, Local numbness, Increased confidence, Tachycardia, Vasoconstriction, Increased blood pressure, Anxiety, Jaw tension, Insomnia.

起效

Insufflated: 2–10 分钟 | NOTE: Rapid onset due to nasal absorption and local anesthetic properties.

摘要

Dimethocaine is a synthetic cocaine-derived local anesthetic with stimulant properties. It acts primarily as a dopamine reuptake inhibitor and voltage-gated sodium channel blocker, producing cocaine-like but generally less intense effects. Despite being perceived as milder, it carries substantial cardiovascular and tissue toxicity risks. Metabolism is dominated by NAT2-mediated N-acetylation, with additional contributions from multiple cytochrome P450 enzymes, resulting in significant inter-individual variability and elevated risk for slow acetylators.

来源

general

Wikipedia contributors. Dimethocaine. Wikipedia, The Free Encyclopedia. https://en.wikipedia.org/wiki/Dimethocaine Lindauer C. Toxicokinetics of Emerging Drugs of Abuse: In vivo and in vitro studies on the metabolic fate of the cocaine-derived designer drug dimethocaine. Universität des Saarlandes, 2014. https://jahrbib.sulb.uni-saarland.de/bitstream/20.500.11880/21949/1/Dissertation_Lindauer_Dimethocaine_final_hhm.pdf Meyer MR, Lindauer C, Maurer HH. Dimethocaine, a synthetic cocaine derivative: Studies on its in vitro metabolism catalyzed by P450s and NAT2. Toxicology Letters. 2014;225(1):139–146. https://doi.org/10.1016/j.toxlet.2013.11.033