TripSit · dextromethorphan + diphenhydramine

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

详情

备注

据报道，这种组合可以减少每种药物的副作用并增强许多娱乐效果。存在血清素综合征、谵妄增加、中枢神经系统抑制、认知抑制、身体损伤、高热、躁狂、偏执和精神病的风险，特别是在较高剂量时。 There is an additional concern of tachycardia, hypertension, and in extreme cases, heart failure.据报道，苯海拉明可抑制 CYP2D6 酶，从而增加 DXM 的水平。据报道，医疗剂量不是一个问题。强烈建议谨慎使用此组合。

查看原文

The combination is reported to reduce the side effects of each drug and potentiate many of the recreational effects. There is a significant risk of serotonin syndrome, increased delirium, CNS depression, cognitive inhibition, risk of physical injury, hyperthermia, mania, paranoia, and psychosis, especially at higher dosages. There is an additional concern of tachycardia, hypertension, and in extreme cases, heart failure. Diphenhydramine is reported to inhibit the CYP2D6 enzyme which can increase levels of DXM. Medical dosages are not reported to be a concern. Caution is strongly recommended with this combination.

来源

author

Abdul Manap, Wright, Gregory, Rostami‐Hodjegan, Meller, Kelm, Lennard, Tucker, & Morice. (1999)

标题

The antitussive effect of dextromethorphan in relation to CYP2D6 activity. British Journal of Clinical Pharmacology, 48(3), 382–387.

链接

https://doi.org/10.1046/j.1365-2125.1999.00029.x

author

Akutsu, T., Kobayashi, K., Sakurada, K., Ikegaya, H., Furihata, T., & Chiba, K. (2007)

标题

Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation. Drug Metabolism and Disposition: The Biological Fate of Chemicals, 35(1), 72–78.

链接

https://doi.org/10.1124/dmd.106.012088

author

Clark, J. H., Meltzer, E. O., & Naclerio, R. M. (2025)

标题

Diphenhydramine: It is time to say a final goodbye. World Allergy Organization Journal, 18(2), 101027.

链接

https://doi.org/10.1016/j.waojou.2025.101027

author

Crazy Steve. (2004)

标题

Mind Expansion: An Experience with DXM & Diphenhydramine (exp33999). Erowid.org.

链接

https://www.erowid.org/experiences/exp.php?ID=33999

author

De Leon, J., & Nikoloff, D. M. (2008)

标题

Paradoxical Excitation on Diphenhydramine May Be Associated with Being a CYP2D6 Ultrarapid Metabolizer: Three Case Reports. CNS Spectrums, 13(2), 133–135.

链接

https://doi.org/10.1017/S109285290001628X

author

Hamelin, B. (2000a)

标题

Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity. Clinical Pharmacology & Therapeutics, 67(5), 466–477.

链接

https://doi.org/10.1067/mcp.2000.106464

author

HANS. (2022)

标题

First Overdose: An Experience with DXM & Diphenhydramine (exp116238). Erowid.org.

链接

https://www.erowid.org/experiences/exp.php?ID=116238

author

Jun, J. H., Thorndike, E. B., & Schindler, C. W. (2004a)

标题

Abuse liability and stimulant properties of dextromethorphan and diphenhydramine combinations in rats. Psychopharmacology, 172(3), 277–282.

链接

https://doi.org/10.1007/s00213-003-1650-4

author

Josie Kins

标题

The DXM and DPH combination, broken down and described

链接

https://disregardeverythingisay.com/post/39670297758/the-dxm-and-dph-combination-broken-down-and

author

Lessard, E., Yessine, M. A., Hamelin, B. A., Gauvin, C., Labbé, L., O’Hara, G., LeBlanc, J., & Turgeon, J. (2001)

标题

Diphenhydramine alters the disposition of venlafaxine through inhibition of CYP2D6 activity in humans. Journal of Clinical Psychopharmacology, 21(2), 175–184.

链接

https://doi.org/10.1097/00004714-200104000-00009

author

Psychonaut Wiki

标题

DXM & DPH

链接

https://psychonautwiki.org/wiki/DXM_%26_DPH

author

Romanelli, F., & Smith, K. M. (2009)

标题

Dextromethorphan abuse: Clinical effects and management. Journal of the American Pharmacists Association, 49(2), e20–e27.

链接

https://doi.org/10.1331/JAPhA.2009.08091

author

Schwartz, A. R., Pizon, A. F., & Brooks, D. E. (2008)

标题

Dextromethorphan-induced serotonin syndrome. Clinical Toxicology, 46(8), 771–773.

链接

https://doi.org/10.1080/15563650701668625

author

The Salvia Shaman. (2025)

标题

Delirium Visions and Teleportation: An Experience with DXM & Diphenhydramine (exp113902). Erowid.org.

链接

https://www.erowid.org/experiences/exp.php?ID=113902

author

u/syrup_ben_goed (n.d.)

标题

The "right way" to do DXM + DPH combo, from an experienced user

链接

https://www.reddit.com/r/Drugs/comments/ajlupr/the_right_way_to_do_dxm_dph_comb

风险等级

不安全 （Unsafe）

物质 A

dextromethorphan

物质 B

diphenhydramine