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正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。
- 详情
- 备注
这种组合存在癫痫发作的显着风险。这种组合很可能会增加彼此的负面副作用，例如恶心、头晕和失去意识。在较高剂量下，普瑞巴林可能会增加苯海拉明的谵妄作用、抑制作用和受伤风险。据报道，医疗剂量不是一个问题。
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There is a significant risk of seizures from this combination. The combination is likely to increase each other’s negative side effects, such as nausea, dizziness, and loss of consciousness. At higher dosages, pregabalin is likely to increase diphenhydramine’s deliriant effects, inhibition, and risk of injury. Medical dosages are not reported to be a concern.
- 来源
- author
- Altair. (n.d.-a)
- 标题
- Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
- 链接
- https://www.erowid.org/experiences/exp.php?ID=69917
- author
- Barker-Haliski, M., & White, H. S. (2015)
- 标题
- Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
- 链接
- https://doi.org/10.1101/cshperspect.a022863
- author
- Ben-Menachem, E. (2004)
- 标题
- Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
- 链接
- https://doi.org/10.1111/j.0013-9580.2004.455003.x
- author
- Medline Plus Medical Encyclopedia (2023)
- 标题
- Diphenhydramine overdose
- 链接
- https://medlineplus.gov/ency/article/002636.htm
- author
- Douke, R. (n.d.)
- 标题
- Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
- 链接
- https://www.erowid.org/experiences/exp.php?ID=83232
- author
- Fakhr, M. S., Motamed Chaboki, P., Ashayeri, H., Sahranavard, P., Mohammadipanah, S., & Zamanabadi, M. N. (2023)
- 标题
- Comparison of the effects of pregabalin and famotidine with pregabalin and diphenhydramine on postoperative abdominal pain. International Journal of Surgery Open, 58, 100674.
- 链接
- https://doi.org/10.1016/j.ijso.2023.100674
- author
- French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
- 标题
- Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.
- 链接
- https://doi.org/10.1212/WNL.0000000000000119
- author
- Gayatri, N. A., & Livingston, J. H. (2006)
- 标题
- Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.
- 链接
- https://doi.org/10.1017/S0012162206000843
- author
- Hitchings, A. W. (2016)
- 标题
- Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
- 链接
- https://doi.org/10.1097/FAD.0000000000000016
- author
- Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
- 标题
- Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
- 链接
- https://doi.org/10.1111/bcp.14348
- author
- Jang, D. H., Manini, A. F., Trueger, N. S., Duque, D., Nestor, N. B., Nelson, L. S., & Hoffman, R. S. (2010)
- 标题
- Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose. Clinical Toxicology, 48(9), 945–948.
- 链接
- https://doi.org/10.3109/15563650.2010.527850
- author
- Kim, H., Kim, S. H., & Kim, J. B. (2021)
- 标题
- Antihistamines as a common cause of new-onset seizures: a single-center observational study. Neurological Sciences: Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 42(6), 2505–2508.
- 链接
- https://doi.org/10.1007/s10072-021-05043-2
- author
- Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
- 标题
- Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
- 链接
- https://doi.org/10.1111/j.1471-4159.2010.06625.x
- author
- Schifano, F., Chiappini, S., Miuli, A., Mosca, A., Santovito, M. C., Corkery, J. M., Guirguis, A., Pettorruso, M., Di Giannantonio, M., & Martinotti, G. (2021)
- 标题
- Focus on Over-the-Counter Drugs’ Misuse: A Systematic Review on Antihistamines, Cough Medicines, and Decongestants. Frontiers in Psychiatry, 12, 657397.
- 链接
- https://doi.org/10.3389/fpsyt.2021.657397
- author
- Sean. (n.d.-b)
- 标题
- Pregabalin - Erowid Exp - “Stay Away.”
- 链接
- https://www.erowid.org/experiences/exp.php?ID=67302
- author
- Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
- 标题
- Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
- 链接
- https://doi.org/10.1080/24734306.2018.1458465
- author
- Wolfson, A. R., Wong, D., Abrams, E. M., Waserman, S., & Sussman, G. L. (2022)
- 标题
- Diphenhydramine: Time to Move on? The Journal of Allergy and Clinical Immunology: In Practice, 10(12), 3124–3130.
- 链接
- https://doi.org/10.1016/j.jaip.2022.07.018
- 风险等级
- 不安全 （Unsafe）
- 物质 A
- diphenhydramine
- 物质 B
- pregabalin
来源与许可
TripSit · 药物资料
TripSit 数据规则：仅限非商业使用，需署名并在每个展示页附来源链接；组合数据仅为快速参考，需结合个体研究判断。
Reference snapshot, not a forum post. Source: TripSit. Noncommercial reuse with TripSit attribution and a source link on every display page; combination data is a quick reference requiring further individual research. https://wiki.tripsit.me/wiki/Factsheets ; https://wiki.tripsit.me/wiki/Drug_combinations . The package.json ISC software tag does not replace these data-specific terms.
Raw source: https://raw.githubusercontent.com/TripSit/drugs/83670cb6bc8863615fcb9be081c87f061b42dea4/combos.json
Fetched at: 2026-10-23T07:01:06.728397+00:00
Record key: combination:["diphenhydramine","pregabalin"]
来源主页：https://wiki.tripsit.me/wiki/Factsheets
组合说明：https://wiki.tripsit.me/wiki/Drug_combinations