TripSit · lithium + diphenhydramine

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

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备注

较高剂量的这种组合可能会导致血清素综合征。建议谨慎限制苯海拉明的医疗剂量（25-50 毫克）。锂盐和苯海拉明都有 QT 延长的风险，联合服用时可能会增加 QT 延长；由于使用者的健康和药物剂量等多种因素，风险会增加。此外，组合可能会增加每种药物的副作用，例如头晕和意识丧失。

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There is a concern of serotonin syndrome at higher dosages of this combination. Caution is recommended in restricting diphenhydramine to medical dosages (25-50mg). Lithium and diphenhydramine both have concerns of QT prolongation which may be increased when taken in combination; risks increase due to a variety of factors such as the health of the user and drug dosages. Additionally, the combination may increase each drug's side effects, such as dizziness and loss of consciousness.

来源

author

Clark, J. H., Meltzer, E. O., & Naclerio, R. M.

标题

Diphenhydramine: It is time to say a final goodbye. World Allergy Organization Journal, 18(2), 101027. (2025)

链接

https://doi.org/10.1016/j.waojou.2025.101027

author

Crouch, M. A., Limon, L., & Cassano, A. T.

标题

Clinical Relevance and Management of Drug‐Related QT Interval Prolongation. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 23(7), 881–908. (2003)

链接

https://doi.org/10.1592/phco.23.7.881.32730

author

Farzam, K., & Tivakaran, V. S.

标题

QT Prolonging Drugs. In StatPearls. StatPearls Publishing. (2025)

链接

http://www.ncbi.nlm.nih.gov/books/NBK534864/

author

Finley, P. R.

标题

Drug Interactions with Lithium: An Update. Clinical Pharmacokinetics, 55(8), 925–941. (2016)

链接

https://doi.org/10.1007/s40262-016-0370-y

author

Hawley, C. J., Loughlin, P. J., Quick, S. J., Gale, T. M., Sivakumaran, T., Hayes, J., & McPhee, S.

标题

Efficacy, safety and tolerability of combined administration of lithium and selective serotonin reuptake inhibitors: a review of the current evidence. International Clinical Psychopharmacology, 15(4), 197–206. (2000)

链接

https://doi.org/10.1097/00004850-200015040-00002

author

Husain, Z., Hussain, K., Nair, R., & Steinman, R.

标题

Diphenhydramine induced QT prolongation and torsade de pointes: An uncommon effect of a common drug. Cardiology Journal, 17(5), 509–511. (2010)

链接

https://journals.viamedica.pl/cardiology_journal/article/view/21341

author

Khan, S., Saud, S., Khan, I., Asif, M., Ismail, O., Salam, A., Yang, T. J., & Norville, K. J.

标题

Serotonin Syndrome Presenting with Concomitant Tramadol and Diphenhydramine Use: A Case Report of an Unlikely Side-Effect. Cureus. (2018)

链接

https://doi.org/10.7759/cureus.2421

author

Massot, O., Rousselle, J.-C., Fillion, M.-P., Januel, D., Plantefol, M., & Fillion, G.

标题

5-HT1B Receptors: A Novel Target for Lithium: Possible Involvement in Mood Disorders. Neuropsychopharmacology, 21(4), 530–541. (1999)

链接

https://doi.org/10.1016/S0893-133X(99)00042-1

author

Mehta, N., & Vannozzi, R.

标题

Lithium‐induced electrocardiographic changes: A complete review. Clinical Cardiology, 40(12), 1363–1367. (2017)

链接

https://doi.org/10.1002/clc.22822

author

Müller-Oerlinghausen, B.

标题

Drug Interactions with Lithium: A Guide for Clinicians. CNS Drugs, 11(1), 41–48. (1999)

链接

https://doi.org/10.2165/00023210-199911010-00004

author

Rosenberg, A. E., Wang, R., & Rosenberg, M. H.

标题

Serotonin Syndrome Associated With High-dose Diphenhydramine Use Complicating Abdominoplasty and Mastopexy. Plastic and Reconstructive Surgery - Global Open, 13(3), e6634. (2025)

链接

https://doi.org/10.1097/GOX.0000000000006634

author

Truedson, P., Ott, M., Lindmark, K., Ström, M., Maripuu, M., Lundqvist, R., & Werneke, U.

标题

Effects of Toxic Lithium Levels on ECG—Findings from the LiSIE Retrospective Cohort Study. Journal of Clinical Medicine, 11(19), 5941. (2022)

链接

https://doi.org/10.3390/jcm11195941

风险等级

谨慎 （Caution）

物质 A

锂盐

物质 B

diphenhydramine