TripSit · diphenhydramine + opioids

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

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备注

这两种物质都是中枢神经系统抑制剂，彼此之间会产生不可预测的强烈增强作用，增加记忆丧失、严重共济失调和意识丧失的可能性。这种相互作用会造成更大的抑制和受伤的风险。 DPH 减少阿片类药物释放的组胺，从而减少阿片类药物的瘙痒副作用。 DPH 可以减少阿片类药物引起的恶心。 DPH 抑制 CYP2D6 活性，从而导致某些阿片类药物的作用减弱，而另一些阿片类药物的作用增强。

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Both substances are CNS depressants, potentiating each other strongly and unpredictably, raising the chances of memory loss, severe ataxia, and unconsciousness. The interaction will cause greater inhibition and risk of injury. DPH reduces histamine release by opioids, which reduces the itching side effect from opioids. DPH may reduce the nausea caused by opioids. DPH inhibits CYP2D6 activity which can lead to a reduction of effects in some opioids and potentiation of effects in others.

来源

author

Akutsu, T., Kobayashi, K., Sakurada, K., Ikegaya, H., Furihata, T., & Chiba, K. (2007)

标题

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链接

https://doi.org/10.1124/dmd.106.012088

author

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标题

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链接

https://doi.org/10.15585/mmwr.mm7141a4

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标题

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链接

https://doi.org/10.1111/j.1365-2125.2010.03653.x

author

Hamelin, B. (2000)

标题

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链接

https://doi.org/10.1067/mcp.2000.106464

author

Heiskanen, T., & Kalso, E. (2012)

标题

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链接

https://doi.org/10.2174/138161212803582423

author

Nahid, N. A., McDonough, C. W., Wei, Y.-J. J., Cicali, E. J., Gong, Y., Fillingim, R. B., & Johnson, J. A. (2024)

标题

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链接

https://doi.org/10.1002/cpt.3314

author

Okutani, H., Lo Vecchio, S., & Arendt‐Nielsen, L. (2024)

标题

Mechanisms and treatment of opioid‐induced pruritus: Peripheral and central pathways. European Journal of Pain, 28(2), 214–230.

链接

https://doi.org/10.1002/ejp.2180

author

Sicari, V., Patel, P., & Zabbo, C. P. (2025)

标题

Diphenhydramine. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK526010/

author

Swegle, J. M., & Logemann, C. (2006)

标题

Management of common opioid-induced adverse effects. American Family Physician, 74(8), 1347–1354.

链接

https://pubmed.ncbi.nlm.nih.gov/17087429/

author

Wei, Y.-J. J., Winterstein, A. G., Schmidt, S., Fillingim, R. B., Daniels, M. J., DeKosky, S. T., & Schmidt, S. (2025)

标题

Association of initiating CYP2D6-metabolized opioids with risks of adverse outcomes in older adults receiving antidepressants: A retrospective cohort study. PLOS Medicine, 22(6), e1004620.

链接

https://doi.org/10.1371/journal.pmed.1004620

author

Whitt, A., & Jortani, S. (2023)

标题

B-337 Case Report: Fatal Opioid Overdose Induced by Over-the-Counter Cold Medication Diphenhydramine. Clinical Chemistry, 69(Supplement_1), hvad097.656.

链接

https://doi.org/10.1093/clinchem/hvad097.656

风险等级

不安全 （Unsafe）

物质 A

diphenhydramine

物质 B

阿片类