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正文中文为机器翻译,仅供参考;专业内容以折叠的原文为准。
- 详情
- 备注
兴奋剂会增加呼吸频率,从而允许使用比正常剂量更高的镇静剂。如果可卡因先失效,娱乐性剂量的 DPH 可能会抑制个体并导致呼吸停止。这两种物质在娱乐剂量下都会使心脏紧张,并可能导致进一步危险的心脏并发症。当较高剂量的 DPH 与可卡因结合在一起时,这两种物质可能会产生更强的增强作用,并具有更大的高铁血红蛋白血症风险。
查看原文
Stimulants increase respiration rate allowing for a higher dose of sedatives than normal. If cocaine wears off first, recreational dosages of DPH may overcome the individual and cause respiratory arrest. Both substances at recreational dosages strain the heart and may lead to further dangerous heart complications. When taken together, both substances can potentially be more reinforcing and have greater risk of methemoglobinemia when higher dosages of DPH are combined with cocaine.
- 来源
- author
- Alanazi, M. Q.
- 标题
- Drugs may be Induced Methemoglobinemia. Journal of Hematology & Thromboembolic Diseases, 06(01). (2017)
- 链接
- https://doi.org/10.4172/2329-8790.1000270
- author
- Banks, M. L., Andersen, M. L., Murnane, K. S., Meyer, R. C., & Howell, L. L.
- 标题
- Behavioral and neurochemical effects of cocaine and diphenhydramine combinations in rhesus monkeys. Psychopharmacology, 205(3), 467–474. (2009)
- 链接
- https://doi.org/10.1007/s00213-009-1555-y
- author
- chrisn
- 标题
- Diphenhydramine [Online post]. Drug-Forum. (2021)
- 链接
- https://drugs-forum.com/wiki/Diphenhydramine
- author
- Eshmandi, M., Mohamed, A., Khalil, B., & Belhaj, A.
- 标题
- Methaemoglobinaemia Associated With Mixed Cocaine and Amphetamine Overdose: A Case Report. Cureus, 16(1), e51748. (2024)
- 链接
- https://doi.org/10.7759/cureus.51748
- author
- Karch, S. B.
- 标题
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- 链接
- https://doi.org/10.1097/00000433-199806000-00008
- author
- Pennefather, J. N.
- 标题
- The effects pf cocaine and diphenhydramine upon the reactivity of rat vas deferens to supramaximal doses of noradrenaline and of other agonists: The mode of action of cocaine. European Journal of Pharmacology, 35(2), 333–339. (1976)
- 链接
- https://doi.org/10.1016/0014-2999(76)90236-3
- author
- Pergolizzi, J. V., Magnusson, P., LeQuang, J. A. K., Breve, F., & Varrassi, G.
- 标题
- Cocaine and Cardiotoxicity: A Literature Review. Cureus, 13(4), e14594. (2021)
- 链接
- https://doi.org/10.7759/cureus.14594
- author
- Sicari, V., Patel, P., & Zabbo, C. P.
- 标题
- Diphenhydramine. In StatPearls. StatPearls Publishing. (2025)
- 链接
- http://www.ncbi.nlm.nih.gov/books/NBK526010/
- author
- Tanda, G., Kopajtic, T. A., & Katz, J. L.
- 标题
- Cocaine-Like Neurochemical Effects of Antihistaminic Medications. Journal of Neurochemistry, 106(1), 147–157. (2008)
- 链接
- https://doi.org/10.1111/j.1471-4159.2008.05361.x
- author
- Wang, Z., & Woolverton, W. L.
- 标题
- Self-administration of cocaine-antihistamine combinations: Super-additive reinforcing effects. European Journal of Pharmacology, 557(2–3), 159–160. (2007)
- 链接
- https://doi.org/10.1016/j.ejphar.2006.11.056
- author
- Wang, Z., & Woolverton, W. L.
- 标题
- Super-additive interaction of the reinforcing effects of cocaine and H1-antihistamines in rhesus monkeys. Pharmacology Biochemistry and Behavior, 91(4), 590–595. (2009)
- 链接
- https://doi.org/10.1016/j.pbb.2008.09.013
- author
- Weichert, I.
- 标题
- Acute Management of Cocaine-Associated Methaemoglobinaemia. Case Reports in Medicine, 2011, 1–3. (2011)
- 链接
- https://doi.org/10.1155/2011/136396
- 风险等级
- 谨慎 (Caution)
- 物质 A
- diphenhydramine
- 物质 B
- 可卡因
来源与许可
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来源主页:https://wiki.tripsit.me/wiki/Factsheets
组合说明:https://wiki.tripsit.me/wiki/Drug_combinations