TripSit · Dextromethorphan

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

详情

别名

dxm robo syrup robotussin dex robitussin DM

分类

解离剂 习惯形成 常规

相互作用

2c-t-x

风险等级

不安全 （Unsafe）

2c-x

风险等级

低风险 · 协同 （Low Risk & Synergy）

5-meo-xxt

备注

关于这种组合的信息很少。

查看原文

Little information exists about this combination.

风险等级

不安全 （Unsafe）

alcohol

备注

这两种物质都会增强另一种物质引起的共济失调和镇静作用，高剂量时可能会导致意外的意识丧失。将受影响的人置于恢复位置，以防止吸入过量呕吐物。此外，中枢神经系统抑制会导致呼吸困难。避免在高于第一平台的任何地方。

查看原文

Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place the affected individual in the recovery position to prevent vomit aspiration from excess. Additionally, CNS depression can lead to difficulty breathing. Avoid on anything higher than 1st plateau.

风险等级

危险（应避免） （Dangerous）

amphetamines

备注

这两种物质都会增加心率，在极端情况下，这些药物引起的恐慌会导致更严重的心脏问题。

查看原文

Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.

风险等级

不安全 （Unsafe）

amt

风险等级

危险（应避免） （Dangerous）

benzodiazepines

备注

小剂量的苯并类药物可以结束一次糟糕的旅行，但这两种物质都会增强另一种物质引起的共济失调和镇静作用，高剂量时可能会导致意外的意识丧失。在失去知觉时，如果不处于恢复姿势，则有呕吐物误吸的风险。

查看原文

Small doses of benzos can end a bad trip, but both substances potentiate the ataxia and sedation caused by the other and this can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.

风险等级

谨慎 （Caution）

caffeine

备注

高剂量的咖啡因具有刺激作用，可能会加剧焦虑，尤其是在分离体验期间。这种组合也可能导致身体不适。然而，个人对咖啡因的反应可能有很大差异，通常受到习惯和偶尔使用等因素的影响。

查看原文

High doses of caffeine can potentially exacerbate anxiety, especially during a dissociative experience, due to its stimulating effects. This combination might also lead to physical discomfort. However, individual responses to caffeine can vary significantly, often influenced by factors like habitual versus occasional usage.

来源

author

Chad J Reissig, Lawrence P Carter, Matthew W Johnson, Miriam Z Mintzer, Margaret A Klinedinst, Roland R Griffiths

标题

High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens

链接

https://pubmed.ncbi.nlm.nih.gov/22526529/

author

Arthur Eumann Mesas, Luz M Leon-Muñoz, Fernando Rodriguez-Artalejo, Esther Lopez-Garcia

标题

The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis

链接

https://pubmed.ncbi.nlm.nih.gov/21880846/

author

M-L Nurminen, L Niittynen, R Korpela & H Vapaatalo

标题

Coffee, caffeine and blood pressure: a critical review

链接

https://www.nature.com/articles/1600899

风险等级

谨慎 （Caution）

cannabis

风险等级

低风险 · 协同 （Low Risk & Synergy）

cocaine

备注

这两种物质都会增加心率，在极端情况下，这些药物引起的恐慌会导致更严重的心脏问题

查看原文

Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues

风险等级

不安全 （Unsafe）

diphenhydramine

备注

据报道，这种组合可以减少每种药物的副作用并增强许多娱乐效果。存在血清素综合征、谵妄增加、中枢神经系统抑制、认知抑制、身体损伤、高热、躁狂、偏执和精神病的风险，特别是在较高剂量时。 There is an additional concern of tachycardia, hypertension, and in extreme cases, heart failure.据报道，苯海拉明可抑制 CYP2D6 酶，从而增加 DXM 的水平。据报道，医疗剂量不是一个问题。强烈建议谨慎使用此组合。

查看原文

The combination is reported to reduce the side effects of each drug and potentiate many of the recreational effects. There is a significant risk of serotonin syndrome, increased delirium, CNS depression, cognitive inhibition, risk of physical injury, hyperthermia, mania, paranoia, and psychosis, especially at higher dosages. There is an additional concern of tachycardia, hypertension, and in extreme cases, heart failure. Diphenhydramine is reported to inhibit the CYP2D6 enzyme which can increase levels of DXM. Medical dosages are not reported to be a concern. Caution is strongly recommended with this combination.

来源

author

Abdul Manap, Wright, Gregory, Rostami‐Hodjegan, Meller, Kelm, Lennard, Tucker, & Morice. (1999)

标题

The antitussive effect of dextromethorphan in relation to CYP2D6 activity. British Journal of Clinical Pharmacology, 48(3), 382–387.

链接

https://doi.org/10.1046/j.1365-2125.1999.00029.x

author

Akutsu, T., Kobayashi, K., Sakurada, K., Ikegaya, H., Furihata, T., & Chiba, K. (2007)

标题

Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation. Drug Metabolism and Disposition: The Biological Fate of Chemicals, 35(1), 72–78.

链接

https://doi.org/10.1124/dmd.106.012088

author

Clark, J. H., Meltzer, E. O., & Naclerio, R. M. (2025)

标题

Diphenhydramine: It is time to say a final goodbye. World Allergy Organization Journal, 18(2), 101027.

链接

https://doi.org/10.1016/j.waojou.2025.101027

author

Crazy Steve. (2004)

标题

Mind Expansion: An Experience with DXM & Diphenhydramine (exp33999). Erowid.org.

链接

https://www.erowid.org/experiences/exp.php?ID=33999

author

De Leon, J., & Nikoloff, D. M. (2008)

标题

Paradoxical Excitation on Diphenhydramine May Be Associated with Being a CYP2D6 Ultrarapid Metabolizer: Three Case Reports. CNS Spectrums, 13(2), 133–135.

链接

https://doi.org/10.1017/S109285290001628X

author

Hamelin, B. (2000a)

标题

Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity. Clinical Pharmacology & Therapeutics, 67(5), 466–477.

链接

https://doi.org/10.1067/mcp.2000.106464

author

HANS. (2022)

标题

First Overdose: An Experience with DXM & Diphenhydramine (exp116238). Erowid.org.

链接

https://www.erowid.org/experiences/exp.php?ID=116238

author

Jun, J. H., Thorndike, E. B., & Schindler, C. W. (2004a)

标题

Abuse liability and stimulant properties of dextromethorphan and diphenhydramine combinations in rats. Psychopharmacology, 172(3), 277–282.

链接

https://doi.org/10.1007/s00213-003-1650-4

author

Josie Kins

标题

The DXM and DPH combination, broken down and described

链接

https://disregardeverythingisay.com/post/39670297758/the-dxm-and-dph-combination-broken-down-and

author

Lessard, E., Yessine, M. A., Hamelin, B. A., Gauvin, C., Labbé, L., O’Hara, G., LeBlanc, J., & Turgeon, J. (2001)

标题

Diphenhydramine alters the disposition of venlafaxine through inhibition of CYP2D6 activity in humans. Journal of Clinical Psychopharmacology, 21(2), 175–184.

链接

https://doi.org/10.1097/00004714-200104000-00009

author

Psychonaut Wiki

标题

DXM & DPH

链接

https://psychonautwiki.org/wiki/DXM_%26_DPH

author

Romanelli, F., & Smith, K. M. (2009)

标题

Dextromethorphan abuse: Clinical effects and management. Journal of the American Pharmacists Association, 49(2), e20–e27.

链接

https://doi.org/10.1331/JAPhA.2009.08091

author

Schwartz, A. R., Pizon, A. F., & Brooks, D. E. (2008)

标题

Dextromethorphan-induced serotonin syndrome. Clinical Toxicology, 46(8), 771–773.

链接

https://doi.org/10.1080/15563650701668625

author

The Salvia Shaman. (2025)

标题

Delirium Visions and Teleportation: An Experience with DXM & Diphenhydramine (exp113902). Erowid.org.

链接

https://www.erowid.org/experiences/exp.php?ID=113902

author

u/syrup_ben_goed (n.d.)

标题

The "right way" to do DXM + DPH combo, from an experienced user

链接

https://www.reddit.com/r/Drugs/comments/ajlupr/the_right_way_to_do_dxm_dph_comb

风险等级

不安全 （Unsafe）

dmt

风险等级

低风险 · 协同 （Low Risk & Synergy）

dox

备注

DOx 类迷幻兴奋剂有可能掩盖 DXM 的作用，并可能导致重新服用剂量达到不安全水平。 DXM 还可以增强 DOx，导致令人不愉快的强烈体验。

查看原文

The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.

风险等级

不安全 （Unsafe）

ghb/gbl

备注

这两种物质都会导致共济失调，并带来呕吐和意识不清的风险。如果个体在醉酒状态下失去知觉，且不采取恢复姿势，则存在严重的呕吐物误吸风险。这个组合很难预测

查看原文

Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the individual falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. This combination is hard to predict

风险等级

危险（应避免） （Dangerous）

ketamine

备注

这两种物质主要通过 NMDA 拮抗作用发挥作用。目前，没有证据表明可能减少这些影响的机制。

查看原文

Both substances primarily exert their effects through NMDA antagonism. Currently, there is no evidence regarding mechanisms that might reduce these effects.

来源

author

Jeanna M. Marraffa

标题

Dextromethorphan

链接

https://doi.org/10.1016/B978-0-12-824315-2.00127-5

author

Georges Mion, Thierry Villevieille

标题

Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings)

链接

https://doi.org/10.1111/cns.12099

author

P. Klepstad, P. C. Borchgrevink

标题

Four years' treatment with ketamine and a trial of dextromethorphan in a patient with severe post-herpetic neuralgia

链接

https://doi.org/10.1111/j.1399-6576.1997.tb04709.x

author

Stephen M. Stahl

标题

Mechanism of action of dextromethorphan/quinidine: comparison with ketamine

链接

https://doi.org/10.1017/S109285291300062X

author

A M Hughes,1 J Rhodes,1 G Fisher,2 M Sellers,3 and J W Growcott1

标题

Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers

链接

https://doi.org/10.1046%2Fj.1365-2125.2002.01602.x

author

Keiji Tabuchi, MD, Zenya Ito, MD, Shigeki Tsuji, MD, Akira Hara, MD, Tetsuro Wada, MD, Jun Kusakari, MD

标题

Effect of Ketamine, Dextromethorphan, and MK-801 on Cochlear Dysfunction Induced by Transient Ischemia

链接

https://doi.org/10.1177/000348940211100107

风险等级

低风险 · 协同 （Low Risk & Synergy）

lithium

备注

将锂与 DXM 结合使用时，存在发生血清素综合征的风险。

查看原文

There is a risk of serotonin syndrome when combining Lithium with DXM.

来源

author

Lenox, R. H., & Hahn, C. G.

标题

Overview of the mechanism of action of lithium in the brain: fifty-year update (2000)

链接

https://pubmed.ncbi.nlm.nih.gov/10826655/

author

Shahani, L.

标题

Venlafaxine Augmentation With Lithium Leading to Serotonin Syndrome (2012)

链接

https://doi.org/10.1176/appi.neuropsych.11080196

author

DeBattista, C., Sofuoglu, M., & Schatzberg, A. F.

标题

Serotonergic synergism: the risks and benefits of combining the selective serotonin reuptake inhibitors with other serotonergic drugs (1998)

链接

https://doi.org/10.1016/s0006-3223(98)00161-9

author

Massot, O.

标题

5-HT1B Receptors: A Novel Target for Lithium: Possible Involvement in Mood Disorders (1999)

链接

https://doi.org/10.1016/S0893-133X(99)00042-1

author

Navarro, A., Perry, C., & Bobo, W. V.

标题

A case of serotonin syndrome precipitated by abuse of the anticough remedy dextromethorphan in a bipolar patient treated with fluoxetine and lithium. (2006)

链接

https://doi.org/10.1016/j.genhosppsych.2005.06.008

风险等级

危险（应避免） （Dangerous）

lsd

风险等级

低风险 · 协同 （Low Risk & Synergy）

maois

备注

血清素综合征的高风险

查看原文

High risk of serotonin syndrome

风险等级

危险（应避免） （Dangerous）

mdma

风险等级

危险（应避免） （Dangerous）

mephedrone

备注

由于这两种药物都会提高血清素水平，因此存在血清素综合征的风险。除了担心高血压和不必要的心脏压力。由于这种组合，还可能导致焦虑和更大的身体不适。

查看原文

Risk of serotonin syndrome as both drugs raise serotonin levels. In addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.

来源

author

J Kehr, F Ichinose, S Yoshitake, M Goiny, T Sievertsson, F Nyberg, T Yoshitake

标题

Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats

链接

https://doi.org/10.1111/j.1476-5381.2011.01499.x

author

Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein

标题

4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse

链接

https://doi.org/10.1124/jpet.111.184119

author

Anna R. Schwartz, Anthony F. Pizon & Daniel E. Brooks

标题

Dextromethorphan-induced serotonin syndrome

链接

https://doi.org/10.1080/15563650701668625

author

DrugBank

标题

Dextromethorphan

链接

https://go.drugbank.com/drugs/DB00514

author

Henderson MG, Fuller RW

标题

Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats

链接

https://doi.org/10.1016/0006-8993(92)91144-4

author

Reissig CJ, Carter LP, Johnson MW, Mintzer MZ, Klinedinst MA, Griffiths RR

标题

High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens

链接

https://doi.org/10.1007/s00213-012-2680-6

author

Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.

标题

Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat

链接

https://doi.org/10.1016/j.toxlet.2011.10.010

风险等级

危险（应避免） （Dangerous）

mescaline

风险等级

低风险 · 协同 （Low Risk & Synergy）

mushrooms

风险等级

低风险 · 协同 （Low Risk & Synergy）

mxe

备注

由于 DXM 和 MXE 都是 SRI，因此将 DXM 与 MXE 结合使用时存在血清素综合征的风险。 MXE 和 DXM 对血清素转运蛋白具有显着的亲和力。

查看原文

There is a risk of serotonin syndrome when combining DXM with MXE, due to DXM and MXE both being SRI’s. MXE and DXM having notable affinities for the serotonin transporter.

来源

author

Bryan L. Roth, Simon Gibbons, Warunya Arunotayanun, Xi-Ping Huang, Vincent Setola, Ric Treble, Les Iversen

标题

The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor

链接

https://doi.org/10.1371/journal.pone.0059334

author

Matteo Marti, Giuseppe Talani, Cristina Miliano, Sabrine Bilel, Francesca Biggio, Jessica Bratzu, Marco Diana, Maria Antonietta De Luca, Liana Fattore

标题

New insights into methoxetamine mechanisms of action: Focus on serotonergic 5-HT2 receptors in pharmacological and behavioral effects in the rat

链接

https://doi.org/10.1016/j.expneurol.2021.113836

author

Laura Hondebrink, Emma E.J. Kasteel, Anke M. Tukker, Fiona M.J. Wijnolts, Anouk H.A. Verboven, Remco H.S. Westerink

标题

Neuropharmacological characterization of the new psychoactive substance methoxetamine

链接

https://doi.org/10.1016/j.neuropharm.2017.04.035

author

Linda L. Werling, Ashleigh Keller, Julie G. Frank, Samer J. Nuwayhid

标题

A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: Treatment of involuntary emotional expression disorder

链接

https://doi.org/10.1016/j.expneurol.2007.06.013

author

Linda Nguyen, Kelan L. Thomas, Brandon P. Lucke-Wold, John Z. Cavendish, Molly S. Crowe, Rae R. Matsumoto

标题

Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders

链接

https://doi.org/10.1016/j.pharmthera.2016.01.016

风险等级

不安全 （Unsafe）

nbomes

风险等级

不安全 （Unsafe）

nitrous

风险等级

低风险 · 协同 （Low Risk & Synergy）

opioids

备注

中枢神经系统抑制、呼吸困难、心脏问题、肝中毒，这些都是非常不安全的组合。此外，如果服用 DXM，他们对阿片类药物的耐受性会略有下降，从而产生额外的协同效应。

查看原文

CNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally if one takes DXM, their tolerance of opiates goes down slightly, thus causing additional synergistic effects.

风险等级

危险（应避免） （Dangerous）

pcp

风险等级

危险（应避免） （Dangerous）

pregabalin

备注

普瑞巴林和DXM可能会相互增强抑制、头晕、镇静等作用。如果剂量较高，可能会导致意外的意识丧失。两种药物都有癫痫发作的风险，联合使用会大大增加。

查看原文

Pregabalin and DXM may increase each other’s effects such as inhibition, dizziness, sedation. At higher doses this can lead to unexpected loss of consciousness. Both drugs have seizure concerns which is greatly increased in combination.

来源

author

Altair. (n.d.-a)

标题

Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”

链接

https://www.erowid.org/experiences/exp.php?ID=69917

author

Barker-Haliski, M., & White, H. S. (2015)

标题

Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.

链接

https://doi.org/10.1101/cshperspect.a022863

author

Ben-Menachem, E. (2004)

标题

Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.

链接

https://doi.org/10.1111/j.0013-9580.2004.455003.x

author

Douke, R. (n.d.)

标题

Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”

链接

https://www.erowid.org/experiences/exp.php?ID=83232

author

French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)

标题

Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.

链接

https://doi.org/10.1212/WNL.0000000000000119

author

Gayatri, N. A., & Livingston, J. H. (2006)

标题

Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.

链接

https://doi.org/10.1017/S0012162206000843

author

Hitchings, A. W. (2016)

标题

Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.

链接

https://doi.org/10.1097/FAD.0000000000000016

author

Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)

标题

Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.

链接

https://doi.org/10.1111/bcp.14348

author

Journey, J. D., Agrawal, S., & Stern, E. (2025)

标题

Dextromethorphan Toxicity. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK538502/

author

Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)

标题

Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.

链接

https://doi.org/10.1111/j.1471-4159.2010.06625.x

author

Oh, S., Agrawal, S., Sabir, S., & Taylor, A. (2025)

标题

Dextromethorphan. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK538216/

author

Sean. (n.d.-b)

标题

Pregabalin - Erowid Exp - “Stay Away.”

链接

https://www.erowid.org/experiences/exp.php?ID=67302

author

Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)

标题

Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.

链接

https://doi.org/10.1080/24734306.2018.1458465

风险等级

不安全 （Unsafe）

ssris

备注

血清素综合征的高风险。

查看原文

High risk of serotonin syndrome.

风险等级

危险（应避免） （Dangerous）

tramadol

风险等级

危险（应避免） （Dangerous）

剂量说明

NOTE: See http://dxm.tripsit.me for mg/weight doses, among other things. Deaths have been reported at 25mg/kg

后遗时间

1-12 小时

剂量

口服

常规

2.5-7.5mg/kg

重剂量

15-20mg/kg

轻度

1.5-2.5mg/kg

强效

7.5-15mg/kg

持续时间

6-8 小时

起效时间

20-60 分钟

相关链接

经验报告

https://www.erowid.org/experiences/subs/exp_DXM.shtml

名称

dextromethorphan

通用名

Dextromethorphan

属性

后遗效应

1–12 小时.

别名

dxm robo syrup robotussin dex robitussin DM

calculator

http://dxm.tripsit.me

分类

解离剂 习惯形成 常规

chart

http://taimapedia.org/images/4/46/DXMDosingChart.png

剂量

Oral First-Plateau: 1.5-2.5mg/kg Second-Plateau: 2.5-7.5mg/kg Third-Plateau: 7.5-15mg/kg Fourth: 15-20mg/kg | NOTE: See http://dxm.tripsit.me for mg/lb doses, among other things. Deaths have been reported at 25mg/kg

持续

6–8 小时

起效

20–60 分钟

摘要

Commonly found in certain over the counter cough medicines. Has dissociative effects similar to ketamine or MXE, though also shares properties with opioids and alcohol. It is recommended to dose DXM through direct ingestion of the drug, without other active ingrediants such as guaifenesin or doxylamine.

效应

Acuity suppression

https://psychonautwiki.org/wiki/Acuity_suppression

Auditory distortion

https://psychonautwiki.org/wiki/Auditory_distortion

Auditory enhancement

https://psychonautwiki.org/wiki/Auditory_enhancement

Auditory hallucinations

https://psychonautwiki.org/wiki/Auditory_hallucinations

Auditory suppression

https://psychonautwiki.org/wiki/Auditory_suppression

Autonomous entities

https://psychonautwiki.org/wiki/Autonomous_entities

Cognitive euphoria

https://psychonautwiki.org/wiki/Cognitive_euphoria

Conceptual thinking

https://psychonautwiki.org/wiki/Conceptual_thinking

Consciousness disconnection

https://psychonautwiki.org/wiki/Consciousness_disconnection

Cough suppression

https://psychonautwiki.org/wiki/Cough_suppression

Creativity enhancement

https://psychonautwiki.org/wiki/Creativity_enhancement

Depersonalization

https://psychonautwiki.org/wiki/Depersonalization

Derealization

https://psychonautwiki.org/wiki/Derealization

Dizziness

https://psychonautwiki.org/wiki/Dizziness

Double vision

https://psychonautwiki.org/wiki/Double_vision

Déjà vu

https://psychonautwiki.org/wiki/D%C3%A9j%C3%A0_vu

Environmental cubism

https://psychonautwiki.org/wiki/Environmental_cubism

Environmental orbism

https://psychonautwiki.org/wiki/Environmental_orbism

External hallucinations

https://psychonautwiki.org/wiki/External_hallucinations

Frame rate suppression

https://psychonautwiki.org/wiki/Frame_rate_suppression

Geometry

https://psychonautwiki.org/wiki/Geometry

Immersion enhancement

https://psychonautwiki.org/wiki/Immersion_enhancement

Information processing suppression

https://psychonautwiki.org/wiki/Information_processing_suppression

Internal hallucinations

https://psychonautwiki.org/wiki/Internal_hallucinations

Memory suppression

https://psychonautwiki.org/wiki/Memory_suppression

Nausea

https://psychonautwiki.org/wiki/Nausea

Pattern recognition suppression

https://psychonautwiki.org/wiki/Pattern_recognition_suppression

Perception of decreased weight

https://psychonautwiki.org/wiki/Perception_of_decreased_weight

Personal bias suppression

https://psychonautwiki.org/wiki/Personal_bias_suppression

Perspective alterations

https://psychonautwiki.org/wiki/Perspective_alterations

Perspective distortions

https://psychonautwiki.org/wiki/Perspective_distortions

Physical autonomy

https://psychonautwiki.org/wiki/Physical_autonomy

Physical euphoria

https://psychonautwiki.org/wiki/Physical_euphoria

Scenarios and plots

https://psychonautwiki.org/wiki/Scenarios_and_plots

Scenery slicing

https://psychonautwiki.org/wiki/Scenery_slicing

Settings, sceneries, and landscapes

https://psychonautwiki.org/wiki/Settings,_sceneries,_and_landscapes

Tactile disconnection

https://psychonautwiki.org/wiki/Tactile_disconnection

Tactile suppression

https://psychonautwiki.org/wiki/Tactile_suppression

Thought deceleration

https://psychonautwiki.org/wiki/Thought_deceleration

Time distortion

https://psychonautwiki.org/wiki/Time_distortion

Unity and interconnectedness

https://psychonautwiki.org/wiki/Unity_and_interconnectedness

Visual disconnection

https://psychonautwiki.org/wiki/Visual_disconnection

Visual sliding

https://psychonautwiki.org/wiki/Visual_sliding

来源

general

Dextromethorphan and its metabolite dextrorphan block alpha3beta4 neuronal nicotinic receptors. - http://www.ncbi.nlm.nih.gov/pubmed/10869398 Dextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys. - http://www.ncbi.nlm.nih.gov/pubmed/11805202 Dextromethorphan psychosis, dependence and physical withdrawal. - http://www.ncbi.nlm.nih.gov/pubmed/16318953 Evaluation the effects of dextromethorphan and midazolam on morphine induced tolerance and dependence in mice. - http://www.ncbi.nlm.nih.gov/pubmed/18819620 Dextromethorphan as a potential rapid-acting antidepressant. - http://www.ncbi.nlm.nih.gov/pubmed/21367535 The treatment of heroin addicts with dextromethorphan: a double-blind comparison of dextromethorphan with chlorpromazine. - http://www.ncbi.nlm.nih.gov/pubmed/2187002 High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens. - http://www.ncbi.nlm.nih.gov/pubmed/22526529 Lack of efficacy of dextromethorphan in managing alcohol withdrawal: a preliminary report of a randomized, double-blind, placebo-controlled trial. - http://www.ncbi.nlm.nih.gov/pubmed/24346753