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正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。
- 详情
- 别名
- oxy oxycontin percocet oxynorm
- 分类
- 阿片类 习惯形成 抑制剂 常规
- 剂量说明
Note: Dosages reflect that while nasal bioavailability (BA) may be less than oral BA, nasal administration can cause an additional 'rush' (due to quicker onset); this may lead to a subjective experience of greater strength than an equivalent oral dose.
- 后遗时间
- 1-24 小时
- 剂量
- 鼻吸
- 常规
- 7.5-15mg
- 轻度
- 2.5-7.5mg
- 强效
- 15-25mg
- 口服
- 常规
- 10-25mg
- 轻度
- 2.5-10mg
- 强效
- 25-40mg
- 效应
- Pain relief Respiratory depression Sedation Constipation Cough suppression Decreased libido Difficulty urinating Itchiness Nausea Pupil constriction Stomach cramps Appetite suppression Euphoria Anxiety suppression Dream potentiation
- 名称
- oxycodone
- 通用名
- Oxycodone
- 属性
- 后遗效应
- 1–24 小时.
- 别名
- oxy oxycontin percocet oxynorm
- 生物利用度
- Oral 60-87% | Insufflated 55-70%
- 分类
- 阿片类 习惯形成 抑制剂 常规
- 检测窗口
- 3–5 天 for minimal use, 5-8 for regular use.
- 剂量
- Oral Light: 2.5-10mg Common: 10-25mg Strong: 25-40mg | Insufflated Light: 2.5-7.5mg Common: 7.5-15mg Strong: 15-25mg | Note: Dosages reflect that, while nasal bioavailability (BA) may be less than oral BA, nasal administration causes an additional 'rush' (due to quicker onset); this may lead to a subjective experience of greater strength than an equivalent oral dose.
- 持续
- Oral_IR: 4–6 小时 | Oral_ER: 6–8 小时. | Insufflated: 3–5 小时. | IV: 3–5 小时.
- 效应
- Pain relief, Respiratory depression, Sedation, Constipation, Cough suppression, Decreased libido, Difficulty urinating, Itchiness, Nausea, Pupil constriction, Stomach cramps, Appetite suppression, Euphoria, Anxiety suppression, Dream potentiation.
- half-life
- 2–4 小时
- marquis
- Pale violet
- 起效
- Oral_IR: 20 分钟 | Oral_ER: 40 分钟 | Insufflated: 2–5 分钟 | IV: 0–1 分钟
- potentiators
- Avoid grapefruit juice, depressants, and diphenhydramine (DPH). These products may react negatively and can cause an overdose. Additionally, it is strongly recommended against consuming greater than 4g APAP (acetaminophen) in a day.
- 摘要
A semisynthetic opioid analgesic developed in 1917, prescribed primarily for pain management. It has become extremely popular as a recreational drug in some areas and carries a high potential for substance use disorder. Anectodal reports indicate the drug being a more 'stimulating' than other opioids.
- 效应
- Anxiety suppression
- https://psychonautwiki.org/wiki/Anxiety_suppression
- Cognitive euphoria
- https://psychonautwiki.org/wiki/Cognitive_euphoria
- Constipation
- https://psychonautwiki.org/wiki/Constipation
- Cough suppression
- https://psychonautwiki.org/wiki/Cough_suppression
- Difficulty urinating
- https://psychonautwiki.org/wiki/Difficulty_urinating
- Internal hallucinations
- https://psychonautwiki.org/wiki/Internal_hallucinations
- Itchiness
- https://psychonautwiki.org/wiki/Itchiness
- Nausea
- https://psychonautwiki.org/wiki/Nausea
- Pain relief
- https://psychonautwiki.org/wiki/Pain_relief
- Physical euphoria
- https://psychonautwiki.org/wiki/Physical_euphoria
- Pupil constriction
- https://psychonautwiki.org/wiki/Pupil_constriction
- Respiratory depression
- https://psychonautwiki.org/wiki/Respiratory_depression
- Sedation
- https://psychonautwiki.org/wiki/Sedation
- Stomach cramps
- https://psychonautwiki.org/wiki/Stomach_cramps
- 来源
- general
- Controlled-release oxycodone-induced seizures. - http://www.ncbi.nlm.nih.gov/pubmed/16368452 Grapefruit juice enhances the exposure to oral oxycodone. - http://www.ncbi.nlm.nih.gov/pubmed/20406214 Oxycodone/paracetamol: a low-dose synergic combination useful in different types of pain. - http://www.ncbi.nlm.nih.gov/pubmed/20670044 Pharmacokinetics and pharmacodynamics of oxycodone when given intravenously and rectally to adult patients with cancer pain. - http://www.ncbi.nlm.nih.gov/pubmed/7818116 Differential effects of food on the bioavailability of controlled-release oxycodone tablets and immediate-release oxycodone solution. - http://www.ncbi.nlm.nih.gov/pubmed/8901078 Oxycodone is found to suppress sodium currents in the thalamic regions of the brain at high doses and is an effect that is independent of the MOR/u-opioid recepter and therefore this mechanism is not blocked by the use of naloxone - http://www.sciencedirect.com/science/article/pii/S0304394009001268 Oxycodone is found to have longer lasting more efficient effects on pain due to neuropathy because of having GABA-B agonist properties -http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091297 Oxycodone when paired with an ultra low dose of naltrexone, an opioid antagonist, oxycodone has a longer duration of pain relief - http://www.sciencedirect.com/science/article/pii/S1526590005004128 Oxycodone has been found to be an effective treatment for restless leg syndrome - http://europepmc.org/abstract/med/8341893 Pharmacokinetics of oxycodone done orally and intramuscularly http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.1992.tb04090.x/abstract
来源与许可
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Reference snapshot, not a forum post. Source: TripSit. Noncommercial reuse with TripSit attribution and a source link on every display page; combination data is a quick reference requiring further individual research. https://wiki.tripsit.me/wiki/Factsheets ; https://wiki.tripsit.me/wiki/Drug_combinations . The package.json ISC software tag does not replace these data-specific terms.
Raw source: https://raw.githubusercontent.com/TripSit/drugs/83670cb6bc8863615fcb9be081c87f061b42dea4/drugs.json
Fetched at: 2026-10-23T07:01:06.728397+00:00
Record key: drug:oxycodone
来源主页：https://wiki.tripsit.me/wiki/Factsheets
组合说明：https://wiki.tripsit.me/wiki/Drug_combinations