TripSit · Ketamine

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

详情

别名

k ket kitty kittens special k

分类

解离剂 习惯形成 常规

相互作用

2c-t-x

风险等级

低风险 · 协同 （Low Risk & Synergy）

2c-x

风险等级

低风险 · 协同 （Low Risk & Synergy）

5-meo-xxt

风险等级

低风险 · 协同 （Low Risk & Synergy）

alcohol

备注

这两种物质都会导致共济失调，并带来呕吐和昏迷的极高风险。如果使用者在醉酒状态下失去知觉，且不采取恢复姿势，则存在严重的呕吐物误吸风险。

查看原文

Both substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.

风险等级

危险（应避免） （Dangerous）

amphetamines

备注

没有意外的相互作用，虽然可能会导致血压升高，但合理剂量不存在问题。由于身体受伤的风险，服用高剂量的这种组合可能是不明智的。

查看原文

No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.

风险等级

谨慎 （Caution）

amt

风险等级

低风险 · 协同 （Low Risk & Synergy）

benzodiazepines

备注

这两种物质都会增强另一种物质引起的共济失调和镇静作用，高剂量时可能会导致意外的意识丧失。在失去知觉时，如果不处于恢复姿势，则有呕吐物误吸的风险。

查看原文

Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.

风险等级

谨慎 （Caution）

caffeine

备注

没有意外的互动。

查看原文

No unexpected interactions.

风险等级

Low Risk & No Synergy

cannabis

风险等级

低风险 · 协同 （Low Risk & Synergy）

cocaine

备注

没有意外的相互作用，虽然可能会导致血压升高，但合理剂量不存在问题。由于身体受伤的风险，服用高剂量的这种组合可能是不明智的。

查看原文

No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.

风险等级

谨慎 （Caution）

dextromethorphan

备注

这两种物质主要通过 NMDA 拮抗作用发挥作用。目前，没有证据表明可能减少这些影响的机制。

查看原文

Both substances primarily exert their effects through NMDA antagonism. Currently, there is no evidence regarding mechanisms that might reduce these effects.

来源

author

Jeanna M. Marraffa

标题

Dextromethorphan

链接

https://doi.org/10.1016/B978-0-12-824315-2.00127-5

author

Georges Mion, Thierry Villevieille

标题

Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings)

链接

https://doi.org/10.1111/cns.12099

author

P. Klepstad, P. C. Borchgrevink

标题

Four years' treatment with ketamine and a trial of dextromethorphan in a patient with severe post-herpetic neuralgia

链接

https://doi.org/10.1111/j.1399-6576.1997.tb04709.x

author

Stephen M. Stahl

标题

Mechanism of action of dextromethorphan/quinidine: comparison with ketamine

链接

https://doi.org/10.1017/S109285291300062X

author

A M Hughes,1 J Rhodes,1 G Fisher,2 M Sellers,3 and J W Growcott1

标题

Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers

链接

https://doi.org/10.1046%2Fj.1365-2125.2002.01602.x

author

Keiji Tabuchi, MD, Zenya Ito, MD, Shigeki Tsuji, MD, Akira Hara, MD, Tetsuro Wada, MD, Jun Kusakari, MD

标题

Effect of Ketamine, Dextromethorphan, and MK-801 on Cochlear Dysfunction Induced by Transient Ischemia

链接

https://doi.org/10.1177/000348940211100107

风险等级

低风险 · 协同 （Low Risk & Synergy）

diphenhydramine

备注

这两种物质都会增强另一种物质引起的共济失调和镇静作用，高剂量时可能会导致意外的意识丧失。在失去知觉时，如果不处于恢复姿势，则有呕吐物误吸的风险。较高剂量的氯胺酮很可能会增加 DPH 的谵妄作用，并且会大大增加受伤、躁狂和精神病的风险。 Medical dosages of both substances are unlikely to cause concern.

查看原文

Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Ketamine has a high likelihood of increasing DPH's deliriant effects at higher dosages and can greatly increase the risk of injury, mania, and psychosis. Medical dosages of both substances are unlikely to cause concern.

来源

author

Bylund, W., Delahanty, L., & Cooper, M.

标题

The Case of Ketamine Allergy. Clinical Practice and Cases in Emergency Medicine, 1(4), 323–325. (2017)

链接

https://doi.org/10.5811/cpcem.2017.7.34405

author

Clark, J. H., Meltzer, E. O., & Naclerio, R. M.

标题

Diphenhydramine: It is time to say a final goodbye. World Allergy Organization Journal, 18(2), 101027. (2025)

链接

https://doi.org/10.1016/j.waojou.2025.101027

author

Rosenbaum, S. B., Gupta, V., Patel, P., & Palacios, J. L.

标题

Ketamine. In StatPearls. StatPearls Publishing. (2025)

链接

http://www.ncbi.nlm.nih.gov/books/NBK470357/

author

Sicari, V., Patel, P., & Zabbo, C. P.

标题

Diphenhydramine. In StatPearls. StatPearls Publishing. (2025)

链接

http://www.ncbi.nlm.nih.gov/books/NBK526010/

风险等级

危险（应避免） （Dangerous）

dmt

风险等级

低风险 · 协同 （Low Risk & Synergy）

dox

备注

氯胺酮和致幻剂往往会相互增强——慢慢来。

查看原文

Ketamine and psychedelics tend to potentiate each other - go slowly.

风险等级

低风险 · 协同 （Low Risk & Synergy）

ghb/gbl

备注

这两种物质都会导致共济失调，并带来呕吐和意识不清的风险。如果使用者在醉酒状态下失去知觉，且不采取恢复姿势，则存在严重的呕吐物误吸风险。

查看原文

Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.

风险等级

危险（应避免） （Dangerous）

lithium

备注

锂可以增强和延长氯胺酮的抗抑郁作用。

查看原文

Lithium may enhance and prolong the antidepressant effects of ketamine.

来源

author

Costi, S., Soleimani, L., Glasgow, A., Brallier, J., Spivack, J., Schwartz, J., Levitch, C. F., Richards, S., Hoch, M., Stade, E. C., Welch, A., Collins, K. A., Feder, A., Iosifescu, D. V., Charney, D. S., & Murrough, J. W. (2019)

标题

Lithium continuation therapy following ketamine in patients with treatment resistant unipolar depression: a randomized controlled trial. Neuropsychopharmacology, 44(10), 1812–1819.

链接

https://doi.org/10.1038/s41386-019-0365-0

author

Diazgranados, N., Ibrahim, L., Brutsche, N. E., Newberg, A., Kronstein, P., Khalife, S., Kammerer, W. A., Quezado, Z., Luckenbaugh, D. A., Salvadore, G., Machado-Vieira, R., Manji, H. K., & Zarate, C. A. (2010)

标题

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression. Archives of General Psychiatry, 67(8), 793.

链接

https://doi.org/10.1001/archgenpsychiatry.2010.90

author

Price, J. B., Yates, C. G., Morath, B. A., Van De Wakker, S. K., Yates, N. J., Butters, K., Frye, M. A., McGee, S. L., & Tye, S. J. (2021)

标题

Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression. Translational Psychiatry, 11(1), 1–12.

链接

https://doi.org/10.1038/s41398-021-01716-w

author

Scheuing, L., Chiu, C.-T., Liao, H.-M., & Chuang, D.-M. (2015)

标题

Antidepressant mechanism of ketamine: perspective from preclinical studies. Frontiers in Neuroscience, 9.

链接

https://doi.org/10.3389/fnins.2015.00249

author

Toulany, J., Cunningham, J. E. A., & Nunes, A. (2025)

标题

Overlap and Divergence in Ketamine and Lithium Response in Bipolar Disorder: A Scoping Review. Pharmaceuticals, 18(11), 1662.

链接

https://doi.org/10.3390/ph18111662

author

Wilkowska, A., Szałach, Ł., & Cubała, W. J. (2020)

标题

Ketamine in Bipolar Disorder: A Review. Neuropsychiatric Disease and Treatment, 16, 2707–2717.

链接

https://doi.org/10.2147/NDT.S282208

风险等级

Low Risk & No Synergy

lsd

风险等级

低风险 · 协同 （Low Risk & Synergy）

maois

备注

MAO-B 抑制剂似乎可以增加氯胺酮的效力。 MAO-A 抑制剂有一些与该组合相关的负面报告，但没有太多可用信息

查看原文

MAO-B inhibitors appear to increase the potency of Ketamine. MAO-A inhbitors have some negative reports associated with the combination but there isn't much information available

风险等级

谨慎 （Caution）

mdma

备注

没有意外的相互作用，虽然可能会导致血压升高，但合理剂量不存在问题。由于身体受伤的风险，服用高剂量的这种组合可能是不明智的。

查看原文

No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.

风险等级

低风险 · 协同 （Low Risk & Synergy）

mescaline

风险等级

低风险 · 协同 （Low Risk & Synergy）

mushrooms

风险等级

低风险 · 协同 （Low Risk & Synergy）

mxe

风险等级

低风险 · 协同 （Low Risk & Synergy）

nbomes

风险等级

低风险 · 协同 （Low Risk & Synergy）

nitrous

风险等级

低风险 · 协同 （Low Risk & Synergy）

opioids

备注

这两种物质都会带来呕吐和昏迷的风险。如果使用者在醉酒状态下失去知觉，且不采取恢复姿势，则存在严重的呕吐物误吸风险。

查看原文

Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.

风险等级

危险（应避免） （Dangerous）

pcp

风险等级

低风险 · 协同 （Low Risk & Synergy）

pregabalin

备注

普瑞巴林和氯胺酮可能会产生协同作用，并增加彼此的负面副作用，例如恶心、头晕和意识丧失。由于癫痫发作的担忧，建议谨慎使用超出医疗剂量的药物，以及针对癫痫发作风险较高和/或行为较高的个人的医疗剂量。

查看原文

Pregabalin and ketamine may synergize and increase each other's negative side effects such as nausea, dizziness, and loss of consciousness. Caution is advised for beyond medical dosages due to seizure concerns, and medical dosages for individuals with higher risk seizure profiles and or behavior.

来源

author

Anwar, S., Cooper, J., Rahman, J., Sharma, C., & Langford, R. (2019)

标题

Prolonged Perioperative Use of Pregabalin and Ketamine to Prevent Persistent Pain after Cardiac Surgery. Anesthesiology, 131(1), 119–131.

链接

https://doi.org/10.1097/ALN.0000000000002751

author

Arendt-Nielsen, L., Mansikka, H., Staahl, C., Rees, H., Tan, K., Smart, T. S., Monhemius, R., Suzuki, R., & Drewes, A. M. (2011)

标题

A Translational Study of the Effects of Ketamine and Pregabalin on Temporal Summation of Experimental Pain. Regional Anesthesia & Pain Medicine, 36(6), 585–591.

链接

https://doi.org/10.1097/AAP.0b013e31822b0db0

author

Az, A., & Doğan, Y. (2024)

标题

Unexpected consequences: A case of ketamine‑induced seizure in procedural sedation. Turkish Journal of Emergency Medicine, 24(4), 259–261.

链接

https://doi.org/10.4103/tjem.tjem_67_24

author

Barker-Haliski, M., & White, H. S. (2015)

标题

Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.

链接

https://doi.org/10.1101/cshperspect.a022863

author

Ben‐Menachem, E. (2004)

标题

Pregabalin Pharmacology and Its Relevance to Clinical Practice. Epilepsia, 45(s6), 13–18.

链接

https://doi.org/10.1111/j.0013-9580.2004.455003.x

author

French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)

标题

Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial. Neurology, 82(7), 590–597.

链接

https://doi.org/10.1212/WNL.0000000000000119

author

Gayatri, N., & Livingston, J. (2006)

标题

Aggravation of epilepsy by anti‐epileptic drugs. Developmental Medicine & Child Neurology, 48(5), 394–398.

链接

https://doi.org/10.1017/S0012162206000843

author

Hitchings, A. W. (2016)

标题

Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.

链接

https://doi.org/10.1097/FAD.0000000000000016

author

Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)

标题

Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.

链接

https://doi.org/10.1111/bcp.14348

author

Kim, J. H., Lee, C. K., Yu, S. H., Min, B. D., Chung, C. E., & Kim, D. C. (2021)

标题

Ketamine-induced generalized convulsive seizure during procedural sedation. Archives of Craniofacial Surgery, 22(2), 119–121.

链接

https://doi.org/10.7181/acfs.2021.00094

author

Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)

标题

Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.

链接

https://doi.org/10.1111/j.1471-4159.2010.06625.x

author

Martinez, V., Cymerman, A., Ben Ammar, S., Fiaud, J. F., Rapon, C., Poindessous, F., Judet, T., Chauvin, M., Bouhassira, D., Sessler, D., Mazoit, X., & Fletcher, D. (2014)

标题

The analgesic efficiency of combined pregabalin and ketamine for total hip arthroplasty: a randomised, double‐blind, controlled study. Anaesthesia, 69(1), 46–52.

链接

https://doi.org/10.1111/anae.12495

author

Shehata, I. M., Kohaf, N. A., ElSayed, M. W., Latifi, K., Aboutaleb, A. M., & Kaye, A. D. (2024)

标题

Ketamine: Pro or antiepileptic agent? A systematic review. Heliyon, 10(2), e24433.

链接

https://doi.org/10.1016/j.heliyon.2024.e24433

author

Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)

标题

Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.

链接

https://doi.org/10.1080/24734306.2018.1458465

author

Zhou, Y., Sun, W., Fu, Y., Wang, J., Fan, J., Liang, Y., Jia, W., & Han, R. (2024)

标题

Effect of esketamine combined with pregabalin on acute postsurgical pain in patients who underwent resection of spinal neoplasms: a randomized controlled trial. Pain, 165(9), e96–e105.

链接

https://doi.org/10.1097/j.pain.0000000000003211

风险等级

谨慎 （Caution）

ssris

风险等级

Low Risk & No Synergy

tramadol

风险等级

危险（应避免） （Dangerous）

剂量说明

NOTE: Ketamine is based on weight. These are figures for the average 150 pound male There is no concrete dose for the "K-Hole" as each user is different.

后遗时间

1-2 小时

剂量

鼻吸

常规

50-125mg

重剂量

175-250mg

轻度

20-50mg

强效

125-175mg

阈值

5-10mg

持续时间

1-2 小时

效应

A feeling of drunkenness and well being at low doses As dose increases the user may begin to feel a disconnection from their body At 'khole' doses the user may become completely disconnected from both body and mind

相关链接

经验报告

https://www.erowid.org/experiences/subs/exp_Ketamine.shtml

名称

氯胺酮

通用名

氯胺酮

属性

后遗效应

1–2 小时

别名

k ket kitty kittens

avoid

Driving, walking, motor activity. Mixing with other depressants such as alcohol, benzodiazepines, and opioids.

分类

解离剂 习惯形成 常规

剂量

Insufflated Threshold: 5-10mg Light: 20-50mg Common: 50-125mg Strong: 125-175mg Heavy: 175-250mg | NOTE: Ketamine is based on weight. These are figures for the average 150 pound male There is no concrete dose for the "K-Hole" as each user is different.

持续

1–2 小时

效应

A feeling of drunkenness and well being at low doses. As dose increases the user may begin to feel a disconnection from their body. At 'khole' doses the user may become completely disconnected from both body and mind.

molecule

http://wiki.tripsit.me/images/7/76/Ketamine.png

起效

Insufflated: 7.5–20 分钟 | Oral: 10–75 分钟 | Intramuscular: 2–7.5 分钟 | Intravenous: 0–2 分钟

摘要

A short-acting dissociative anaesthetic and hallucinogen commonly used in medicine. It is the prototypical dissociative, and is widely used at sub-anesthetic doses recreationally. Small doses are comparable with alcohol, while larger doses are immobilising and lead to psychedelic experiences: the "K-Hole."

效应

Acuity suppression

https://psychonautwiki.org/wiki/Acuity_suppression

Amnesia

https://psychonautwiki.org/wiki/Amnesia

Analysis enhancement

https://psychonautwiki.org/wiki/Analysis_enhancement

Anxiety suppression

https://psychonautwiki.org/wiki/Anxiety_suppression

Auditory distortion

https://psychonautwiki.org/wiki/Auditory_distortion

Auditory enhancement

https://psychonautwiki.org/wiki/Auditory_enhancement

Auditory hallucinations

https://psychonautwiki.org/wiki/Auditory_hallucinations

Auditory suppression

https://psychonautwiki.org/wiki/Auditory_suppression

Autonomous entities

https://psychonautwiki.org/wiki/Autonomous_entities

Compulsive redosing

https://psychonautwiki.org/wiki/Compulsive_redosing

Conceptual thinking

https://psychonautwiki.org/wiki/Conceptual_thinking

Consciousness disconnection

https://psychonautwiki.org/wiki/Consciousness_disconnection

Depersonalization

https://psychonautwiki.org/wiki/Depersonalization

Derealization

https://psychonautwiki.org/wiki/Derealization

Disinhibition

https://psychonautwiki.org/wiki/Disinhibition

Dizziness

https://psychonautwiki.org/wiki/Dizziness

Double vision

https://psychonautwiki.org/wiki/Double_vision

Déjà vu

https://psychonautwiki.org/wiki/D%C3%A9j%C3%A0_vu

Environmental cubism

https://psychonautwiki.org/wiki/Environmental_cubism

Environmental orbism

https://psychonautwiki.org/wiki/Environmental_orbism

External hallucinations

https://psychonautwiki.org/wiki/External_hallucinations

Frame rate suppression

https://psychonautwiki.org/wiki/Frame_rate_suppression

Geometry

https://psychonautwiki.org/wiki/Geometry

Immersion enhancement

https://psychonautwiki.org/wiki/Immersion_enhancement

Information processing suppression

https://psychonautwiki.org/wiki/Information_processing_suppression

Internal hallucinations

https://psychonautwiki.org/wiki/Internal_hallucinations

Memory suppression

https://psychonautwiki.org/wiki/Memory_suppression

Motor control loss

https://psychonautwiki.org/wiki/Motor_control_loss

Nausea

https://psychonautwiki.org/wiki/Nausea

Pattern recognition suppression

https://psychonautwiki.org/wiki/Pattern_recognition_suppression

Perception of decreased weight

https://psychonautwiki.org/wiki/Perception_of_decreased_weight

Personal bias suppression

https://psychonautwiki.org/wiki/Personal_bias_suppression

Perspective alterations

https://psychonautwiki.org/wiki/Perspective_alterations

Perspective distortions

https://psychonautwiki.org/wiki/Perspective_distortions

Physical autonomy

https://psychonautwiki.org/wiki/Physical_autonomy

Physical euphoria

https://psychonautwiki.org/wiki/Physical_euphoria

Scenarios and plots

https://psychonautwiki.org/wiki/Scenarios_and_plots

Scenery slicing

https://psychonautwiki.org/wiki/Scenery_slicing

Settings, sceneries, and landscapes

https://psychonautwiki.org/wiki/Settings,_sceneries,_and_landscapes

Spontaneous tactile sensations

https://psychonautwiki.org/wiki/Spontaneous_tactile_sensations

Subconscious communication

https://psychonautwiki.org/wiki/Subconscious_communication

Suggestibility enhancement

https://psychonautwiki.org/wiki/Suggestibility_enhancement

Synaesthesia

https://psychonautwiki.org/wiki/Synaesthesia

Tactile disconnection

https://psychonautwiki.org/wiki/Tactile_disconnection

Tactile suppression

https://psychonautwiki.org/wiki/Tactile_suppression

Thought deceleration

https://psychonautwiki.org/wiki/Thought_deceleration

Time distortion

https://psychonautwiki.org/wiki/Time_distortion

Unity and interconnectedness

https://psychonautwiki.org/wiki/Unity_and_interconnectedness

Visual disconnection

https://psychonautwiki.org/wiki/Visual_disconnection

Visual sliding

https://psychonautwiki.org/wiki/Visual_sliding

来源

general

Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model ps.. - https://www.ncbi.nlm.nih.gov/pubmed/16143730 The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations - http://www.ncbi.nlm.nih.gov/pubmed/11094005 Subanesthetic ketamine infusion therapy: a retrospective analysis of a novel therapeutic approach to complex regional pain syndrome - http://www.ncbi.nlm.nih.gov/pubmed/15367304 Effects of ketamine on precipitated opiate withdrawal - http://www.ncbi.nlm.nih.gov/pubmed/16963828 Low-dose ketamine with multimodal postcesarean delivery analgesia: a randomized controlled trial - http://www.ncbi.nlm.nih.gov/pubmed/21224020 Chronic ketamine exposure induces permanent impairment of brain functions in adolescent cynomolgus monkeys - http://www.ncbi.nlm.nih.gov/pubmed/23145560 GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects - http://www.ncbi.nlm.nih.gov/pubmed/23303054 From "Special K" to "Special M": the evolution of the recreational use of ketamine and methoxetamine - http://www.ncbi.nlm.nih.gov/pubmed/23421859 Daily oral ketamine for the treatment of depression and anxiety in patients receiving hospice care: a 28-day open-label proof-of-concept trial - http://www.ncbi.nlm.nih.gov/pubmed/23805864 Brain damages in ketamine addicts as revealed by magnetic resonance imaging - http://www.ncbi.nlm.nih.gov/pubmed/23882190 Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial - http://www.ncbi.nlm.nih.gov/pubmed/23982301 Are sexes affected differently by ketamine? An exploratory study in ketamine users - http://www.ncbi.nlm.nih.gov/pubmed/24106975 Therapeutic infusions of ketamine: do the psychoactive effects matter - http://www.ncbi.nlm.nih.gov/pubmed/24480515 The absolute bioavailability of racemic ketamine from a novel sublingual formulation - http://www.ncbi.nlm.nih.gov/pubmed/24977293 The mood stabilizer lithium potentiates the antidepressant-like effects and ameliorates oxidative stress induced by acute ketamine in a mouse model.. - http://www.ncbi.nlm.nih.gov/pubmed/25548109 The promise of ketamine for treatment-resistant depression: current evidence and future directions - http://www.ncbi.nlm.nih.gov/pubmed/25649308 Antidepressants do not increase the lethality of ketamine in mice - http://www.ncbi.nlm.nih.gov/pubmed/6849728 Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain - http://www.ncbi.nlm.nih.gov/pubmed/7659431 Ketamine and norketamine plasma concentrations after i.v., nasal and rectal administration in children - http://www.ncbi.nlm.nih.gov/pubmed/8881626 Tissue distribution of ketamine in a mixed drug fatality - http://www.ncbi.nlm.nih.gov/pubmed/9397567 [From the racemate to the eutomer: (S)-ketamine. Renaissance of a substance?] - http://www.ncbi.nlm.nih.gov/pubmed/9451486 Chronic abuse has led to a case of kidney and liver damage http://www.ncbi.nlm.nih.gov/pubmed/24982568 ketamine in the hospital setting can raise blood pressure and is something to be considered when using it: "Emergency care in the streets" Ketamine shows promise in treating suicidal ideation in patients with depression - http://www.biologicalpsychiatryjournal.com/article/S0006-3223(09)00519-8/abstract