本条目为第三方公开资料的归档，仅用于学术研究与科普，不构成任何操作指导或医学建议；物质处理涉及法律与健康风险，请在专业、合法的条件下自行核验。
正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。
- 详情
- 别名
- buttons mesc san san-pedro
- 分类
- 致幻剂 常规
- 相互作用
- 2c-t-x
- 风险等级
- 谨慎 （Caution）
- 2c-x
- 风险等级
- 谨慎 （Caution）
- 5-meo-xxt
- 备注
5-MeO 类色胺的相互作用是不可预测的
查看原文
The 5-MeO class of tryptamines can be unpredictable in their interactions
- 风险等级
- 谨慎 （Caution）
- alcohol
- 风险等级
- Low Risk & Decrease
- amphetamines
- 备注
迷幻药会放大兴奋剂引起的注意力集中和焦虑，导致思维循环的风险增加
查看原文
The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
- 风险等级
- 谨慎 （Caution）
- amt
- 风险等级
- 危险（应避免） （Dangerous）
- benzodiazepines
- 风险等级
- Low Risk & Decrease
- caffeine
- 备注
高剂量的咖啡因会让人感到不舒服，迷幻药会加剧这种不适
查看原文
High doses of caffeine are uncomfortable and this will be magnified by psychedelics
- 风险等级
- Low Risk & No Synergy
- cannabis
- 备注
大麻与致幻剂具有出乎意料的强烈且有些不可预测的协同作用。
查看原文
Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- 风险等级
- 谨慎 （Caution）
- cocaine
- 备注
迷幻药会放大兴奋剂引起的注意力集中和焦虑，导致思维循环的风险增加
查看原文
The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
- 风险等级
- 谨慎 （Caution）
- dextromethorphan
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- diphenhydramine
- 备注
25-50 毫克的 DPH 可能有助于缓解麦司卡林的副作用，例如恶心和焦虑。在较高剂量时，应注意不要将谵妄剂 (DPH) 与麦斯卡林联合使用。麦斯卡林除了增加严重伤害和精神创伤的风险外，还可能增加 DPH 的神志不清和负面影响。
查看原文
At 25-50mg, DPH may assist with side effects of the mescaline such as nausea and anxiety. At higher dosages, the combination of a deliriant (DPH) and mescaline is cautioned against. Mescaline is likely to increase the deliriant and negative effects of DPH, in addition to increasing the risk of severe injury and mental trauma.
- 来源
- author
- Dinis-Oliveira, R. J., Pereira, C. L., & Dias da Silva, D. (2019)
- 标题
- Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions. Current Molecular Pharmacology, 12(3), 184–194.
- 链接
- https://doi.org/10.2174/1874467211666181010154139
- author
- ScienceDirect Topics. (n.d.)
- 标题
- Mescaline - an overview.
- 链接
- https://www.sciencedirect.com/topics/neuroscience/mescaline
- author
- Schaefer, T. S., Patel, P., & Zito, P. M. (2025)
- 标题
- Antiemetic Histamine H1 Receptor Blockers. In StatPearls. StatPearls Publishing.
- 链接
- http://www.ncbi.nlm.nih.gov/books/NBK533003/
- author
- Schifano, F., Chiappini, S., Miuli, A., Mosca, A., Santovito, M. C., Corkery, J. M., Guirguis, A., Pettorruso, M., Di Giannantonio, M., & Martinotti, G. (2021)
- 标题
- Focus on Over-the-Counter Drugs’ Misuse: A Systematic Review on Antihistamines, Cough Medicines, and Decongestants. Frontiers in Psychiatry, 12, 657397.
- 链接
- https://doi.org/10.3389/fpsyt.2021.657397
- author
- Vamvakopoulou, I. A., Narine, K. A. D., Campbell, I., Dyck, J. R. B., & Nutt, D. J. (2023)
- 标题
- Mescaline: The forgotten psychedelic. Neuropharmacology, 222, 109294.
- 链接
- https://doi.org/10.1016/j.neuropharm.2022.109294
- author
- Wolfson, A. R., Wong, D., Abrams, E. M., Waserman, S., & Sussman, G. L. (2022)
- 标题
- Diphenhydramine: Time to Move on? The Journal of Allergy and Clinical Immunology: In Practice, 10(12), 3124–3130.
- 链接
- https://doi.org/10.1016/j.jaip.2022.07.018
- 风险等级
- 谨慎 （Caution）
- dmt
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- dox
- 风险等级
- 谨慎 （Caution）
- ghb/gbl
- 风险等级
- Low Risk & Decrease
- ketamine
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- lithium
- 备注
有大量报告表明这种组合具有较高的癫痫和精神病风险。
查看原文
There are a large number of reports indicating a high seizure and psychosis risk from this combination.
- 来源
- author
- Sandeep M Nayak, Natalie Gukasyan, Frederick S Barrett , Earth Erowid , Fire Erowid , Roland R Griffiths
- 标题
- Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports
- 链接
- https://doi.org/10.1055/a-1524-2794
- author
- Erowid
- 标题
- Erowid Interactions
- 链接
- https://erowid.org/chemicals/lsd/lsd_interactions.shtml
- author
- freshboi88
- 标题
- I Was Only on One Dose
- 链接
- https://erowid.org/experiences/exp.php?ID=93681
- author
- YouWerentYouAnymore
- 标题
- Brought My Worst Thoughts to Life
- 链接
- https://erowid.org/experiences/exp.php?ID=110780
- author
- Otto Simonsson, Peper S. Hendricks, Richard Chambers, Walter Osika, Simon B. Goldberg
- 标题
- Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics
- 链接
- https://doi.org/10.1016/j.jad.2023.01.073
- 风险等级
- 危险（应避免） （Dangerous）
- lsd
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- maois
- 风险等级
- 谨慎 （Caution）
- mdma
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- mushrooms
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- mxe
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- nbomes
- 风险等级
- 谨慎 （Caution）
- nitrous
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- opioids
- 风险等级
- Low Risk & No Synergy
- pcp
- 风险等级
- 低风险 · 协同 （Low Risk & Synergy）
- pregabalin
- 备注
由于麦斯卡林的刺激作用和普瑞巴林在较高剂量下可能引起癫痫发作，因此应谨慎使用。普瑞巴林可以减少麦司卡林的血管收缩、焦虑和其他副作用。此外，普瑞巴林可能会增加麦司卡林的抑制作用和受伤风险。
查看原文
Caution should be given due to mescaline’s stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the vasoconstriction, anxiety, and other side effects of mescaline. Additionally, Pregabalin may increase mescaline’s inhibition and risk of injury.
- 来源
- author
- Altair. (n.d.-a)
- 标题
- Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
- 链接
- https://www.erowid.org/experiences/exp.php?ID=69917
- author
- Barker-Haliski, M., & White, H. S. (2015)
- 标题
- Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
- 链接
- https://doi.org/10.1101/cshperspect.a022863
- author
- Ben-Menachem, E. (2004)
- 标题
- Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
- 链接
- https://doi.org/10.1111/j.0013-9580.2004.455003.x
- author
- Douke, R. (n.d.)
- 标题
- Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
- 链接
- https://www.erowid.org/experiences/exp.php?ID=83232
- author
- Freidel, N., Kreuder, L., Rabinovitch, B. S., Chen, F. Y., Huang, R. S. T., & Lewis, E. C. (2024)
- 标题
- Psychedelics, epilepsy, and seizures: a review. Frontiers in Pharmacology, 14.
- 链接
- https://doi.org/10.3389/fphar.2023.1326815
- author
- French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
- 标题
- Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial. Neurology, 82(7), 590–597.
- 链接
- https://doi.org/10.1212/WNL.0000000000000119
- author
- Gayatri, N. A., & Livingston, J. H. (2006)
- 标题
- Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.
- 链接
- https://doi.org/10.1017/S0012162206000843
- author
- Hitchings, A. W. (2016)
- 标题
- Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
- 链接
- https://doi.org/10.1097/FAD.0000000000000016
- author
- Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
- 标题
- Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
- 链接
- https://doi.org/10.1111/bcp.14348
- author
- Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
- 标题
- Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
- 链接
- https://doi.org/10.1111/j.1471-4159.2010.06625.x
- author
- Sean. (n.d.-b)
- 标题
- Pregabalin - Erowid Exp - “Stay Away.”
- 链接
- https://www.erowid.org/experiences/exp.php?ID=67302
- author
- Simonsson, O., Goldberg, S. B., Chambers, R., Osika, W., Long, D. M., & Hendricks, P. S. (2022)
- 标题
- Prevalence and associations of classic psychedelic-related seizures in a population-based sample. Drug and Alcohol Dependence, 239, 109586.
- 链接
- https://doi.org/10.1016/j.drugalcdep.2022.109586
- author
- Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
- 标题
- Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
- 链接
- https://doi.org/10.1080/24734306.2018.1458465
- author
- Soto-Angona, Ó., Fortea, A., Fortea, L., Martínez-Ramírez, M., Santamarina, E., López, F. J. G., Knudsen, G. M., & Ona, G. (2024)
- 标题
- Do classic psychedelics increase the risk of seizures? A scoping review. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 85, 35–42.
- 链接
- https://doi.org/10.1016/j.euroneuro.2024.05.002
- 风险等级
- 谨慎 （Caution）
- ssris
- 风险等级
- Low Risk & Decrease
- tramadol
- 备注
由于曲马多降低了阈值，并且麦斯卡林可能导致癫痫发作，因此这种组合可能会导致癫痫发作。
查看原文
This combination can cause seizures due to the lowering of the threshold by tramadol and the potential of mescaline to cause seziures.
- 风险等级
- 不安全 （Unsafe）
- 剂量说明
NOTE: Doses are for Mescaline HCl
- 后遗时间
- 3-5 小时
- 剂量
- 口服
- 常规
- 200-300mg
- 重剂量
- 500-700mg+
- 轻度
- 100-200mg
- 强效
- 300-500mg
- 阈值
- 100mg
- 持续时间
- 6-12 小时
- 效应
- Euphoria empathy insight brightened colour Closed/Open eye visuals enhanced tactile sensation mental/physical stimulation decreased appetite pupil dilation restlessness change in perception ego softening sweating/chills muscle tension confusion insomnia
- 起效时间
- 60-180 分钟
- 相关链接
- 经验报告
- https://www.erowid.org/experiences/subs/exp_Mescaline.shtml
- 名称
- mescaline
- 通用名
- Mescaline
- 属性
- 后遗效应
- 3–5 小时.
- 别名
- buttons mesc san san-pedro
- 分类
- 致幻剂 常规
- 剂量
- Oral Threshold: 100mg Light: 100-200mg Common: 200-300mg Strong: 300-500mg Heavy: 500-700mg+ | NOTE: Doses are for Mescaline HCl
- 持续
- 6–12 小时.
- 效应
- Euphoria, empathy, insight, brightened colour, Closed/Open eye visuals, enhanced tactile sensation, mental/physical stimulation, decreased appetite, pupil dilation, restlessness, change in perception, ego softening, sweating/chills, muscle tension, confusion, insomnia.
- marquis
- Strong orange
- 起效
- 60-180+ minutes
- 摘要
A psychedelic of the phenethylamine family. The drug is found in many cacti, such as Peyote and San Pedro, and has a long history of use. Mescaline can be found naturally and is often syntheized as a synthetic compound.
- 效应
- 8B Geometry - Exposure to inner mechanics of consciousness
- https://psychonautwiki.org/wiki/8B_Geometry_-_Exposure_to_inner_mechanics_of_consciousness
- Acuity enhancement
- https://psychonautwiki.org/wiki/Acuity_enhancement
- After images
- https://psychonautwiki.org/wiki/After_images
- Analysis enhancement
- https://psychonautwiki.org/wiki/Analysis_enhancement
- Auditory distortion
- https://psychonautwiki.org/wiki/Auditory_distortion
- Auditory enhancement
- https://psychonautwiki.org/wiki/Auditory_enhancement
- Auditory hallucinations
- https://psychonautwiki.org/wiki/Auditory_hallucinations
- Autonomous entities
- https://psychonautwiki.org/wiki/Autonomous_entities
- Bodily control enhancement
- https://psychonautwiki.org/wiki/Bodily_control_enhancement
- Colour enhancement
- https://psychonautwiki.org/wiki/Colour_enhancement
- Colour shifting
- https://psychonautwiki.org/wiki/Colour_shifting
- Conceptual thinking
- https://psychonautwiki.org/wiki/Conceptual_thinking
- Delusions
- https://psychonautwiki.org/wiki/Delusions
- Drifting
- https://psychonautwiki.org/wiki/Drifting
- Emotion enhancement
- https://psychonautwiki.org/wiki/Emotion_enhancement
- Feelings of interdependent opposites
- https://psychonautwiki.org/wiki/Feelings_of_interdependent_opposites
- Geometry
- https://psychonautwiki.org/wiki/Geometry
- Immersion enhancement
- https://psychonautwiki.org/wiki/Immersion_enhancement
- Increased heart rate
- https://psychonautwiki.org/wiki/Increased_heart_rate
- Internal hallucinations
- https://psychonautwiki.org/wiki/Internal_hallucinations
- Memory suppression
- https://psychonautwiki.org/wiki/Memory_suppression
- Nausea
- https://psychonautwiki.org/wiki/Nausea
- Novelty enhancement
- https://psychonautwiki.org/wiki/Novelty_enhancement
- Pattern recognition enhancement
- https://psychonautwiki.org/wiki/Pattern_recognition_enhancement
- Personal bias suppression
- https://psychonautwiki.org/wiki/Personal_bias_suppression
- Personal meaning enhancement
- https://psychonautwiki.org/wiki/Personal_meaning_enhancement
- Perspective alterations
- https://psychonautwiki.org/wiki/Perspective_alterations
- Physical euphoria
- https://psychonautwiki.org/wiki/Physical_euphoria
- Pupil dilation
- https://psychonautwiki.org/wiki/Pupil_dilation
- Scenarios and plots
- https://psychonautwiki.org/wiki/Scenarios_and_plots
- Scenery slicing
- https://psychonautwiki.org/wiki/Scenery_slicing
- Settings, sceneries, and landscapes
- https://psychonautwiki.org/wiki/Settings,_sceneries,_and_landscapes
- Spirituality enhancement
- https://psychonautwiki.org/wiki/Spirituality_enhancement
- Spontaneous tactile sensations
- https://psychonautwiki.org/wiki/Spontaneous_tactile_sensations
- Stimulation
- https://psychonautwiki.org/wiki/Stimulation
- Suggestibility enhancement
- https://psychonautwiki.org/wiki/Suggestibility_enhancement
- Symmetrical texture repetition
- https://psychonautwiki.org/wiki/Symmetrical_texture_repetition
- Synaesthesia
- https://psychonautwiki.org/wiki/Synaesthesia
- Tactile enhancement
- https://psychonautwiki.org/wiki/Tactile_enhancement
- Thought acceleration
- https://psychonautwiki.org/wiki/Thought_acceleration
- Thought loops
- https://psychonautwiki.org/wiki/Thought_loops
- Time distortion
- https://psychonautwiki.org/wiki/Time_distortion
- Tracers
- https://psychonautwiki.org/wiki/Tracers
- Transformations
- https://psychonautwiki.org/wiki/Transformations
- Unity and interconnectedness
- https://psychonautwiki.org/wiki/Unity_and_interconnectedness
- Wakefulness
- https://psychonautwiki.org/wiki/Wakefulness
- 来源
- general
- CLINICAL SYNDROMES AND BIOCHEMICAL ALTERATIONS FOLLOWING MESCALINE, LYSERGIC ACID DIETHYLAMIDE, PSILOCYBIN AND A COMBINATION OF THE THREE PSYCHOTOM.. - http://www.ncbi.nlm.nih.gov/pubmed/14156873
来源与许可
TripSit · 药物资料
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Reference snapshot, not a forum post. Source: TripSit. Noncommercial reuse with TripSit attribution and a source link on every display page; combination data is a quick reference requiring further individual research. https://wiki.tripsit.me/wiki/Factsheets ; https://wiki.tripsit.me/wiki/Drug_combinations . The package.json ISC software tag does not replace these data-specific terms.
Raw source: https://raw.githubusercontent.com/TripSit/drugs/83670cb6bc8863615fcb9be081c87f061b42dea4/drugs.json
Fetched at: 2026-10-23T07:01:06.728397+00:00
Record key: drug:mescaline
来源主页：https://wiki.tripsit.me/wiki/Factsheets
组合说明：https://wiki.tripsit.me/wiki/Drug_combinations