TripSit · diphenhydramine + caffeine

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

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备注

咖啡因作为兴奋剂可能会掩盖 DPH 的一些负面副作用，导致清醒妄想，这在谵妄状态下会引起额外的担忧。兴奋剂的组合会增加心脏的负担，可能会引起一些身体不适，并有机会引起心血管问题，例如复杂性心动过速。除了增加彼此的负面副作用之外，这种组合在较高剂量下可能会增加焦虑水平和思维循环的风险。据报道，医疗剂量不是一个问题。

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Caffeine as a stimulant may mask some negative side effects of DPH, leading to delusions of sobriety, which has additional concerns in states of delirium. The combination of stimulants will increase strain on the heart and may cause some physical discomfort, and has the chance to cause cardiovascular issues such as complex tachycardia. The combination may increase anxiety levels and risks of thought loops at higher dosages, in addition to increasing each other's negative side effects. Medical dosages are reported to not be a concern.

来源

author

Clark, J. H.; Meltzer, E. O.; Naclerio, R. M. (2025)

标题

Diphenhydramine: It is time to say a final goodbye. World Allergy Organization Journal, 18(2), 101027.

链接

https://doi.org/10.1016/j.waojou.2025.101027

author

Evans, J.; Richards, J. R.; Battisti, A. S. (2025)

标题

Caffeine. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK519490/

author

McAtee, K. J.; Brillhart, D.; Barbuto, A. F.; Hiller, H. M. (2022)

标题

Wide complex tachycardia secondary to massive diphenhydramine overdose: a case report. Journal of Emergency and Critical Care Medicine, 6(0).

链接

https://doi.org/10.21037/jeccm-21-33

author

Murray, A.; Traylor, J. (2025)

标题

Caffeine Toxicity. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK532910/

author

Institute of Medicine (US) Committee on Military Nutrition Research (2001)

标题

Pharmacology of Caffeine. In Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. National Academies Press (US).

链接

https://www.ncbi.nlm.nih.gov/books/NBK223808/

author

Sicari, V.; Patel, P.; Zabbo, C. P. (2025)

标题

Diphenhydramine. In StatPearls. StatPearls Publishing.

链接

http://www.ncbi.nlm.nih.gov/books/NBK526010/

author

Tharion, W. J.; Kobrick, J. L.; Lieberman, H. R.; Fine, B. J. (1993)

标题

Effects of caffeine and diphenhydramine on auditory evoked cortical potentials. Perceptual and Motor Skills, 76(3 Pt 1), 707–715.

链接

https://doi.org/10.2466/pms.1993.76.3.707

风险等级

谨慎 （Caution）

物质 A

diphenhydramine

物质 B

咖啡因