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TripSit · amphetamines + pregabalin

TripSit 参考资料 · 相互作用 2026-10-23

本条目为第三方公开资料的归档,仅用于学术研究与科普,不构成任何操作指导或医学建议;物质处理涉及法律与健康风险,请在专业、合法的条件下自行核验。

正文中文为机器翻译,仅供参考;专业内容以折叠的原文为准。

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备注

这种组合存在癫痫发作的显着风险。安非他明会增加呼吸频率,因此需要比正常剂量更高的镇静剂剂量。如果安非他明首先失效,娱乐性剂量的普瑞巴林可能会抑制个体并导致呼吸停止。这两种物质在娱乐剂量下都会导致心脏紧张,并可能导致进一步危险的心脏并发症。

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There is a significant risk of seizures from this combination. Amphetamines increase respiration rate allowing for a higher dose of sedatives than normal. If amphetamines wears off first, recreational dosages of pregabalin may overcome the individual and cause respiratory arrest. Both substances at recreational dosages cause strain of the heart and may lead to further dangerous heart complications.

来源
author
Martin, D., & Le, J. K. (2023)
标题
Amphetamine. In StatPearls. StatPearls Publishing.
链接
https://www.ncbi.nlm.nih.gov/books/NBK556103/
author
Altair. (n.d.-a)
标题
Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.”
链接
https://www.erowid.org/experiences/exp.php?ID=69917
author
Barker-Haliski, M., & White, H. S. (2015)
标题
Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.
链接
https://doi.org/10.1101/cshperspect.a022863
author
Ben-Menachem, E. (2004)
标题
Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18.
链接
https://doi.org/10.1111/j.0013-9580.2004.455003.x
author
Douke, R. (n.d.)
标题
Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.”
链接
https://www.erowid.org/experiences/exp.php?ID=83232
author
French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
标题
Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597.
链接
https://doi.org/10.1212/WNL.0000000000000119
author
Gayatri, N. A., & Livingston, J. H. (2006)
标题
Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398.
链接
https://doi.org/10.1017/S0012162206000843
author
Hitchings, A. W. (2016)
标题
Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154.
链接
https://doi.org/10.1097/FAD.0000000000000016
author
Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
标题
Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440.
链接
https://doi.org/10.1111/bcp.14348
author
Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
标题
Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561.
链接
https://doi.org/10.1111/j.1471-4159.2010.06625.x
author
Sean. (n.d.-b)
标题
Pregabalin - Erowid Exp - “Stay Away.”
链接
https://www.erowid.org/experiences/exp.php?ID=67302
author
Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
标题
Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20.
链接
https://doi.org/10.1080/24734306.2018.1458465
风险等级
不安全 (Unsafe)
物质 A
amphetamines
物质 B
pregabalin
来源与许可

TripSit · 药物资料

TripSit 数据规则:仅限非商业使用,需署名并在每个展示页附来源链接;组合数据仅为快速参考,需结合个体研究判断。

Reference snapshot, not a forum post. Source: TripSit. Noncommercial reuse with TripSit attribution and a source link on every display page; combination data is a quick reference requiring further individual research. https://wiki.tripsit.me/wiki/Factsheets ; https://wiki.tripsit.me/wiki/Drug_combinations . The package.json ISC software tag does not replace these data-specific terms. Raw source: https://raw.githubusercontent.com/TripSit/drugs/83670cb6bc8863615fcb9be081c87f061b42dea4/combos.json Fetched at: 2026-10-23T07:01:06.728397+00:00 Record key: combination:["amphetamines","pregabalin"]

来源主页:https://wiki.tripsit.me/wiki/Factsheets
组合说明:https://wiki.tripsit.me/wiki/Drug_combinations