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正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。
- 详情
- 备注
由于这两种药物都会提高血清素水平，因此存在血清素综合征的风险。除了引起高血压和不必要的心脏负担之外，兴奋剂还会增加摇头丸的神经毒性作用。由于这种组合，还可能导致焦虑和更大的身体不适。
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Risk of serotonin syndrome as both drugs raise serotonin levels. Stimulants also increase the neurotoxic effects of MDMA, in addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.
- 来源
- author
- J Kehr, F Ichinose, S Yoshitake, M Goiny, T Sievertsson, F Nyberg, T Yoshitake
- 标题
- Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats
- 链接
- https://doi.org/10.1111/j.1476-5381.2011.01499.x
- author
- Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein
- 标题
- 4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse
- 链接
- https://doi.org/10.1124/jpet.111.184119
- author
- Gough B, Ali SF, Slikker W Jr, Holson RR.
- 标题
- Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate. (1991)
- 链接
- https://doi.org/10.1016/0091-3057(91)90137-q
- author
- Schmidt CJ, Levin JA, Lovenberg W.
- 标题
- In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. (1987)
- 链接
- https://doi.org/10.1016/0006-2952(87)90729-5
- author
- Bankson MG, Cunningham KA.
- 标题
- 3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions. (2001)
- 链接
- https://pubmed.ncbi.nlm.nih.gov/11356903/
- author
- A.C. Parrott
- 标题
- Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity (2002)
- 链接
- https://doi.org/10.1016/S0091-3057(01)00711-0
- author
- Lisa H. Gold & George F. Koob
- 标题
- MDMA produces stimulant-like conditioned locomotor activity. (1989)
- 链接
- https://doi.org/10.1007/BF00445556
- author
- Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.
- 标题
- Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat
- 链接
- https://doi.org/10.1016/j.toxlet.2011.10.010
- 风险等级
- 危险（应避免） （Dangerous）
- 物质 A
- mephedrone
- 物质 B
- mdma
来源与许可
TripSit · 药物资料
TripSit 数据规则：仅限非商业使用，需署名并在每个展示页附来源链接；组合数据仅为快速参考，需结合个体研究判断。
Reference snapshot, not a forum post. Source: TripSit. Noncommercial reuse with TripSit attribution and a source link on every display page; combination data is a quick reference requiring further individual research. https://wiki.tripsit.me/wiki/Factsheets ; https://wiki.tripsit.me/wiki/Drug_combinations . The package.json ISC software tag does not replace these data-specific terms.
Raw source: https://raw.githubusercontent.com/TripSit/drugs/83670cb6bc8863615fcb9be081c87f061b42dea4/combos.json
Fetched at: 2026-10-23T07:01:06.728397+00:00
Record key: combination:["mephedrone","mdma"]
来源主页：https://wiki.tripsit.me/wiki/Factsheets
组合说明：https://wiki.tripsit.me/wiki/Drug_combinations