TripSit · mephedrone + tramadol

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

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休闲剂量的血清素综合征和癫痫发作的风险很高。这两种物质都会影响心脏，如果剂量较高，可能会导致进一步危险的心脏并发症。两者都会减弱彼此的效果，因此，如果一种药物先于另一种药物失效，则可能会因缺乏对抗作用而服用过量。合用可能会增加彼此的副作用，如头晕、嗜睡等。如果剂量较高，这种组合可能会增加彼此的副作用，例如谵妄、躁狂和精神病。

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There is a high risk of serotonin syndrome and seizures at recreational dosages. Both substances affect the heart and may lead to further dangerous heart complications at higher dosages. Both can dull each other's effects, so if one wears off before the other it's possible to overdose due to the lack of counteraction. The combination may increase each other's side effects, such as dizziness and drowsiness. At higher dosages, the combination may increase each other’s side effects, such as delirium, mania, and psychosis.

来源

author

Boostani, R., & Derakhshan, S.

标题

Tramadol induced seizure: A 3-year study. Caspian Journal of Internal Medicine, 3(3), 484–487 (2012)

链接

N/A

author

Ener, R. A., Meglathery, S. B., Decker, W. A. V., & Gallagher, R. M.

标题

Serotonin Syndrome and Other Serotonergic Disorders: Table 1. Pain Medicine, 4(1), 63–74 (2003)

链接

https://doi.org/10.1046/j.1526-4637.2003.03005.x

author

Hadlock, G. C., Webb, K. M., McFadden, L. M., Chu, P. W., Ellis, J. D., Allen, S. C., Andrenyak, D. M., Vieira-Brock, P. L., German, C. L., Conrad, K. M., Hoonakker, A. J., Gibb, J. W., Wilkins, D. G., Hanson, G. R., & Fleckenstein, A. E.

标题

4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse. The Journal of Pharmacology and Experimental Therapeutics, 339(2), 530–536 (2011)

链接

https://doi.org/10.1124/jpet.111.184119

author

Kehr, J., Ichinose, F., Yoshitake, S., Goiny, M., Sievertsson, T., Nyberg, F., & Yoshitake, T.

标题

Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats: Mephedrone increases both DA and 5-HT in rat brain. British Journal of Pharmacology, 164(8), 1949–1958 (2011)

链接

https://doi.org/10.1111/j.1476-5381.2011.01499.x

author

Lagard, C., Vodovar, D., Chevillard, L., Callebert, J., Caillé, F., Pottier, G., Liang, H., Risède, P., Tournier, N., & Mégarbane, B.

标题

Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat. Pharmaceuticals, 15(10), 1254 (2022)

链接

https://doi.org/10.3390/ph15101254

author

Meng, H., Cao, J., Kang, J., Ying, X., Ji, J., Reynolds, W., & Rampe, D.

标题

Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat. Toxicology Letters, 208(1), 62–68 (2012)

链接

https://doi.org/10.1016/j.toxlet.2011.10.010

author

Sansone, R. A., & Sansone, L. A.

标题

Tramadol: seizures, serotonin syndrome, and coadministered antidepressants. Psychiatry (Edgmont (Pa.: Township)), 6(4), 17–21 (2009)

链接

N/A

风险等级

危险（应避免） （Dangerous）

物质 A

mephedrone

物质 B

曲马多