TripSit · diphenhydramine + mephedrone

正文中文为机器翻译，仅供参考；专业内容以折叠的原文为准。

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休闲剂量的血清素综合征风险很高。两者都会减弱彼此的效果，因此，如果一种药物先于另一种药物失效，则可能会因缺乏对抗作用而服用过量。据报道，医疗剂量并不是普通人群所关心的问题。这两种物质都会影响心脏，如果剂量较高，可能会导致进一步危险的心脏并发症。合用可能会增加彼此的副作用，如头晕、嗜睡等。在较高剂量下，组合可能会增加彼此的副作用，例如谵妄、躁狂和精神病。

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There is a high risk of serotonin syndrome at recreational dosages. Both can dull each other's effects, so if one wears off before the other it's possible to overdose due to the lack of counteraction. Medical dosages are reported not to be a concern for the general population. Both substances affect the heart and may lead to further dangerous heart complications at higher dosages. The combination may increase each other's side effects, such as dizziness and drowsiness. At higher dosages, the combination may increase each other's side effects, such as delirium, mania, and psychosis.

来源

author

Clark, J. H., Meltzer, E. O., & Naclerio, R. M.

标题

Diphenhydramine: It is time to say a final goodbye. World Allergy Organization Journal, 18(2), 101027 (2025)

链接

https://doi.org/10.1016/j.waojou.2025.101027

author

Ener, R. A., Meglathery, S. B., Decker, W. A. V., & Gallagher, R. M.

标题

Serotonin Syndrome and Other Serotonergic Disorders: Table 1. Pain Medicine, 4(1), 63-74 (2003)

链接

https://doi.org/10.1046/j.1526-4637.2003.03005.x

author

Hadlock, G. C., Webb, K. M., McFadden, L. M., Chu, P. W., Ellis, J. D., Allen, S. C., Andrenyak, D. M., Vieira-Brock, P. L., German, C. L., Conrad, K. M., Hoonakker, A. J., Gibb, J. W., Wilkins, D. G., Hanson, G. R., & Fleckenstein, A. E.

标题

4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse. The Journal of Pharmacology and Experimental Therapeutics, 339(2), 530-536 (2011)

链接

https://doi.org/10.1124/jpet.111.184119

author

Kehr, J., Ichinose, F., Yoshitake, S., Goiny, M., Sievertsson, T., Nyberg, F., & Yoshitake, T.

标题

Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats: Mephedrone increases both DA and 5-HT in rat brain. British Journal of Pharmacology, 164(8), 1949-1958 (2011)

链接

https://doi.org/10.1111/j.1476-5381.2011.01499.x

author

Meng, H., Cao, J., Kang, J., Ying, X., Ji, J., Reynolds, W., & Rampe, D.

标题

Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat. Toxicology Letters, 208(1), 62-68 (2012)

链接

https://doi.org/10.1016/j.toxlet.2011.10.010

author

Varghese, E., Abate, M. A., Hu, L., Kaplan, J., Kraner, J., Long, D. L., Sorg, M., Mock, A., Greenwald, M., & Andrew, T.

标题

Characterization of Diphenhydramine-Related Accidental Overdose Deaths. Academic Forensic Pathology, 5(1), 105-115 (2015)

链接

https://doi.org/10.23907/2015.011

风险等级

危险（应避免） （Dangerous）

物质 A

diphenhydramine

物质 B

mephedrone